inovmedИнновационная медицина КубаниInnovative Medicine of Kuban2541-9897Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 110.35401/2541-9897-2025-10-1-27-33inovmed-1061Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESЧто скрывается за лейкоареозом? Углубленное изучение методом мультивоксельной магнитно-резонансной спектроскопииBeyond the Surface: Delving Deeper Into Leukoaraiosis With Multivoxel Magnetic Resonance Spectroscopyhttps://orcid.org/0009-0009-3505-6155РамешР.RameshRagitha

Рамеш Рагита, соискатель ученой степени PhD, кафедра радиодиагностики

Каттанкулатур, шт. Тамилнад – 603203

Ragitha Ramesh, PhD Scholar, Department of Radiodiagnosis, SRM Medical College Hospital and Research Centre

Kattankulathur, Tamil Nadu – 603203

https://orcid.org/0000-0001-9793-5782СуббиахА.SubbiahArunan

Суббиах Арунан, профессор и заведующий, кафедра неврологии

Каттанкулатур, шт. Тамилнад – 603203

Arunan Subbiah, Professor and Head, Department of Neurology, SRM Medical College Hospital and Research Centre

Kattankulathur, Tamil Nadu – 603203

https://orcid.org/0000-0001-7603-0255АйаппанС.AiyappanSenthilkumar

Айаппан Сентилкумар, профессор и заведующий, кафедра радиодиагностики

Каттанкулатур, шт. Тамилнад – 603203

Senthilkumar Aiyappan, Professor and Head, Department of Radiodiagnosis, SRM Medical College Hospital and Research Centre

Kattankulathur, Tamil Nadu – 603203

https://orcid.org/0009-0001-8182-2545РамешС.RameshSabari

Рамеш Сабари, ассистент-профессор, кафедра радиодиагностики

Каттанкулатур, шт. Тамилнад – 603203

Sabari Ramesh, Assistant Professor, Department of Radiodiagnosis, SRM Medical College Hospital and Research Centre

Kattankulathur, Tamil Nadu – 603203

Больница и исследовательский центр медицинского колледжа SRM, Институт науки и технологий SRMИндияSRM Medical College Hospital and Research Centre, SRM Institute of Science and TechnologyIndia2025300320251012733Copyright © Рамеш Р., Суббиах А., Айаппан С., Рамеш С., 20252025Рамеш Р., Суббиах А., Айаппан С., Рамеш С.Ramesh R., Subbiah A., Aiyappan S., Ramesh S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.innovmedkub.ru/jour/article/view/1061Цель

Цель: Изучить метаболические изменения у пациентов с лейкоареозом посредством мультивоксельной магнитно-резонансной спектроскопии (МРС), уделив особое внимание перивентрикулярному белому веществу, и проанализировать биохимические изменения, связанные с лейкоареозом, и их влияние на объем поражения.

Методы

Методы: В данном проспективном исследовании приняли участие 64 пациента (средний возраст: 66,40 ± 8,96 лет; 54 мужчины и 10 женщин), имевших в анамнезе лейкоареоз и направленных на МРТ, в ходе которой им проведена мультивоксельная МРС. Для сравнения мультивоксельную МРС также выполнили 128 здоровым участникам, соотносящихся по возрасту и полу (средний возраст: 61,98 ± 8,18 лет; 40 мужчин и 88 женщин) и вошедших в контрольную группу. Соотношения метаболитов NAA/Cr, NAA/Cho и Cho/Cr, проанализированные с помощью мультивоксельной МРС, коррелировали с объемом поражения, измеренным полуавтоматической программой.

Результаты

Результаты: Соотношение NAA/Cr было достоверно ниже, а соотношение NAA/Cho достоверно выше в контрольной группе по сравнению с пациентами с лейкоареозом (p<0,0001); кроме того, соотношение Cho/Cr было достоверно выше в контроль- ><0,0001) ); кроме того, соотношение Cho/Cr было достоверно выше в контроль-ной группе по сравнению с пациентами с лейкоареозом (p<0,0034) . Это свидетельствует о том, что пациенты с лейкоареозом демонстрируют существенные метаболические различия по сравнению со здоровыми участниками. Кроме того, не наблюдалось корреляции между соотношением метаболитов и объемом поражения, что указывает на то, что выраженность гиперинтенсивности белого вещества не связана с метаболическими изменениями при лейкоареозе.

Заключение

Заключение: Данное исследование расширяет понимание лейкоареоза и подчеркивает потенциал применения мультивоксельной МРС в качестве биомаркера для ранней диагностики лейкоареоза.

Objective

Objective: To investigate metabolite changes in patients with leukoaraiosis employing multivoxel magnetic resonance spectroscopy (MRS) with the focus on periventricular white matter and explicate the biochemical alterations associated with leukoaraiosis and their impact on lesion load.

Methods

Methods: This prospective study was conducted on 64 patients with a known history of leukoaraiosis (mean age, 66.40±8.96 years; 54 men and 10 women) referred for magnetic resonance imaging, wherein MRS was performed. For comparison, 128 age- and gender-matched healthy individuals (mean age, 61.98±8.18 years; 40 men and 88 women) who comprised the control group also underwent MRS. We correlated metabolite ratios (NAA/Cr, NAA/Cho, and Cho/Cr) analyzed on MRS with lesion load measured by semiautomated software.

Results

Results: The NAA/Cr ratio was significantly lower, whereas the NAA/Cho ratio was significantly higher in the control group compared with the patients with leukoaraiosis (P <.0001) . The Cho/Cr ratio was also significantly higher in the controls compared with the patients with leukoaraiosis (P <.0034) . This suggests that patients with leukoaraiosis exhibit significant metabolic differences compared with healthy controls. We observed no correlation between the metabolite ratios and lesion load, which indicates that the degree of white matter hyperintensities is not related to the metabolic changes in leukoaraiosis.

Conclusions

Conclusions: This study explicates the understanding of leukoaraiosis and underscores the potential of MRS as a biomarker for early diagnosis of leukoaraiosis.

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The authors declare that there are no conflicts of interest present.