<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2541-9897-2025-10-1-42-48</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-1063</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Влияние миокардита вирусной этиологии на течение беременности и родов</article-title><trans-title-group xml:lang="en"><trans-title>Impact of Viral Myocarditis on the Course of Pregnancy and Delivery</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7029-7167</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муратова</surname><given-names>Н. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Muratova</surname><given-names>Nigora Ju.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Муратова Нигора Джураевна, д. м. н., доцент кафедры акушерства и гинекологии</p><p>100000, Ташкент, ул. Махтумкули, 103</p></bio><bio xml:lang="en"><p>Nigora Ju. Muratova, Dr. Sci. (Med.), Associate Professor at the Department of Obstetrics and Gynecology</p><p>Mahtumquli ko’chasi, 103, Tashkent, 100000</p></bio><email xlink:type="simple">muratova-84@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3516-2010</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бабаджанова</surname><given-names>Г. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Babadjanova</surname><given-names>Guldjahan S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бабаджанова Гулджахан Саттаровна, д. м. н., профессор кафедры акушерства и гинекологии</p><p>Ташкент</p></bio><bio xml:lang="en"><p>Guldjahan S. Babadjanova, Dr. Sci. (Med.), Professor at the Department of Obstetrics and Gynecology</p><p>Tashkent</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7182-4902</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уринбаева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Urinbaeva</surname><given-names>Nilufar A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уринбаева Нилуфар Абдужаббаровна, директор</p><p>Ташкент</p></bio><bio xml:lang="en"><p>Nilufar A. Urinbaeva, Director</p><p>Tashkent</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-6843-1363</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эшонходжаева</surname><given-names>Д. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Eshonkhodjaeva</surname><given-names>Dildora Ju.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эшонходжаева Дилдора Джураевна, докторант, кафедра акушерства и гинекологии</p><p>100000, Ташкент, ул. Махтумкули, 103</p></bio><bio xml:lang="en"><p>Dildora Ju. Eshonkhodjaeva, Doctoral Candidate, Department of Obstetrics and Gynecology</p><p>Tashkent</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ташкентский государственный стоматологический институт</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Tashkent State Dental Institute</institution><country>Uzbekistan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Ташкентская медицинская академия</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Tashkent Medical Academy</institution><country>Uzbekistan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Республиканский перинатальный центр</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Republican Perinatal Center</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2025</year></pub-date><volume>10</volume><issue>1</issue><fpage>42</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Муратова Н.Д., Бабаджанова Г.С., Уринбаева Н.А., Эшонходжаева Д.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Муратова Н.Д., Бабаджанова Г.С., Уринбаева Н.А., Эшонходжаева Д.Д.</copyright-holder><copyright-holder xml:lang="en">Muratova N.J., Babadjanova G.S., Urinbaeva N.A., Eshonkhodjaeva D.J.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/1063">https://www.innovmedkub.ru/jour/article/view/1063</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность: COVID-19 является респираторной инфекцией, которая в некоторых случаях у беременных может привести к осложнениям со стороны сердца, в частности, к развитию миокардита.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: Нами проведены исследования влияния COVID-ассоциированного миокардита на течение беременности в Республиканском перинатальном центре в 2021–2022 гг. Всего обследовано 147 беременных с миокардитом, из них 95 женщин, перенесших COVID-19, и 52 беременные с хроническим очаговым миокардитом. Выполнены инструментальные исследования (электрокардиография, эхокардиография, УЗИ) и лабораторные (тропонин Т1) методы исследования.</p></sec><sec><title>Выводы</title><p>Выводы: COVID-19, перенесенный женщиной во время беременности, может привести к развитию ковид-ассоциированного миокардита с признаками недостаточности кровообращения (68%), в отличие от хронического очагового миокардита – с развитием нарушения кровообращения и хронической сердечной недостаточности (84,7%). На эхограмме метаболические изменения были больше характерны для беременных 1-й группы с ковид-ассоциированным миокардитом по сравнению с беременными с вялотекущим очаговым миокардитом, однако патологических изменений было больше выявлено во 2-й группе, что свидетельствует о более выраженных изменениях миокарда у беременных женщин во 2-группе с хроническим очаговым миокардитом.</p></sec><sec><title>Заключение</title><p>Заключение: Течение гестации у беременных с ковид-ассоциированным миокардитом характеризовалось развитием гипертензивного синдрома, повышением угрозы прерывания беременности, синдромом отставания роста плода и неубедительным состоянием плода, но реже, чем во 2-й группе с хроническим очаговым миокардитом, что являлось показанием к оперативному родоразрешению.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background: COVID-19 is mainly a respiratory infection; however, in some cases, it can result in cardiac complications in pregnant women leading to the development of myocarditis.</p></sec><sec><title>Material and methods</title><p>Material and methods: In 2021-2022 we studied the impact of COVID-19-associated myocarditis on the course of pregnancy in the Republican Perinatal Center (Tashkent, Republic of Uzbekistan). We examined a total of 147 pregnant women with myocarditis (of them, 95 women had COVID-19 while pregnant and 52 women had chronic focal myocarditis). The patients underwent electrocardiography, echocardiography, ultrasonography, and laboratory studies (troponin T1).</p></sec><sec><title>Results</title><p>Results: COVID-19 in pregnant women can lead to COVID-19-associated myocarditis with signs of circulatory failure (68%), in contrast to chronic focal myocarditis with impaired circulation and chronic heart failure (84.7%). Metabolic changes on echocardiography were more typical of COVID-19-associated myocarditis (group 1) than indolent focal myocarditis (group 2); however, pathological changes were more common in group 2, indicating more pronounced changes in the myocardium of pregnant women with chronic focal myocarditis.</p></sec><sec><title>Conclusions</title><p>Conclusions: The course of gestation in women with COVID-19-associated myocarditis was characterized by the hypertensive syndrome, increased risk of miscarriage, intrauterine growth restriction, and nonreassuring fetal status, but these complications were less common compared with group 2 with chronic focal myocarditis, in which case operative vaginal delivery is indicated.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>коронавирусная инфекция COVID-19</kwd><kwd>миокардит</kwd><kwd>беременные женщины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>myocarditis</kwd><kwd>pregnant women</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pierce-Williams RAM, Burd J, Felder L, et al. Clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnancies: a United States cohort study. Am J Obstet Gynecol MFM. 2020;2(3):100134. PMID: 32391519. PMCID: PMC7205698. https://doi.org/10.1016/j.ajogmf.2020.100134</mixed-citation><mixed-citation xml:lang="en">Pierce-Williams RAM, Burd J, Felder L, et al. Clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnancies: a United States cohort study. Am J Obstet Gynecol MFM. 2020;2(3):100134. PMID: 32391519. PMCID: PMC7205698. https://doi.org/10.1016/j.ajogmf.2020.100134</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Dominguez F, Kühl U, Pieske B, Garcia-Pavia P, Tschöpe C. Update on myocarditis and inflammatory cardiomyopathy: reemergence of endomyocardial biopsy. Rev Esp Cardiol (Engl Ed). 2016;69(2):178–187. PMID: 26795929. https://doi.org/10.1016/j.rec.2015.10.015</mixed-citation><mixed-citation xml:lang="en">Dominguez F, Kühl U, Pieske B, Garcia-Pavia P, Tschöpe C. Update on myocarditis and inflammatory cardiomyopathy: reemergence of endomyocardial biopsy. Rev Esp Cardiol (Engl Ed). 2016;69(2):178–187. PMID: 26795929. https://doi.org/10.1016/j.rec.2015.10.015</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Уринбаева Н.А., Эшонходжаева Д.Д. Ковид-ассоциированный миокардит как осложнение гестации после перенесенного коронавируса. Журнал репродуктивного здоровья и уронефрологических исследований. 2022;3(4):43–45.</mixed-citation><mixed-citation xml:lang="en">Urinbaeva NA, Eshonkhojaeva DJ. Covid-associated myocarditis as a complication of gestation after coronavirus. Journal of Reproductive Health and Uro-Nephrology Research. 2022;3(4):43– 45. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hajra A, Bandyopadhyay D, Heise LR, Bhadra R, Ball S, Hajra SK. Zika and pregnancy: a comprehensive review. Am J Reprod Immunol. 2017;77(2):10.1111/aji.12607. PMID: 27885741. https://doi.org/10.1111/aji.12607</mixed-citation><mixed-citation xml:lang="en">Hajra A, Bandyopadhyay D, Heise LR, Bhadra R, Ball S, Hajra SK. Zika and pregnancy: a comprehensive review. Am J Reprod Immunol. 2017;77(2):10.1111/aji.12607. PMID: 27885741. https://doi.org/10.1111/aji.12607</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jamieson DJ, Honein MA, Rasmussen SA, et al; Novel Influenza A (H1N1) Pregnancy Working Group. H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet. 2009;374(9688):451–458. PMID: 19643469. https://doi.org/10.1016/S0140-6736(09)61304-0</mixed-citation><mixed-citation xml:lang="en">Jamieson DJ, Honein MA, Rasmussen SA, et al; Novel Influenza A (H1N1) Pregnancy Working Group. H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet. 2009;374(9688):451–458. PMID: 19643469. https://doi.org/10.1016/S0140-6736(09)61304-0</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415–426. PMID: 32105680. PMCID: PMC7093856. https://doi.org/10.1016/j.ajog.2020.02.017</mixed-citation><mixed-citation xml:lang="en">Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415–426. PMID: 32105680. PMCID: PMC7093856. https://doi.org/10.1016/j.ajog.2020.02.017</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Федоровых Т.И., Егорян Д.С. Врожденные пороки сердца и беременность. Главный врач Юга России. 2008;(1):27–28.</mixed-citation><mixed-citation xml:lang="en">Fedorovykh TI, Egoryan DS. Congenital heart disease and pregnancy. Glavnyi vrach Yuga Rossii. 2008;(1):27–28. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Głuszak M, Borowiecka E, Borowiecka-ElwertowskaA, Barcz E. Ostra niewydolność krazenia w przebiegu zapalenia mieśnia sercowego w I trymestrze ciazy. Ginekol Pol. 2013;84(6):476–479. (In Polish). PMID: 24032268.</mixed-citation><mixed-citation xml:lang="en">Głuszak M, Borowiecka E, Borowiecka-ElwertowskaA, Barcz E. Ostra niewydolność krazenia w przebiegu zapalenia mieśnia sercowego w I trymestrze ciazy. Ginekol Pol. 2013;84(6):476–479. (In Polish). PMID: 24032268.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Moodley J, Soma-Pillay P, Buchmann E, Pattinson RC. Hypertensive disorders in pregnancy: 2019 National guideline. S Afr Med J. 2019;109(9):12723. PMID: 31635598.</mixed-citation><mixed-citation xml:lang="en">Moodley J, Soma-Pillay P, Buchmann E, Pattinson RC. Hypertensive disorders in pregnancy: 2019 National guideline. S Afr Med J. 2019;109(9):12723. PMID: 31635598.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mendoza M, Garcia-Ruiz I, Maiz N, et al. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2020;127(11):1374–1380. PMID: 32479682. PMCID: PMC7300912. https://doi.org/10.1111/1471-0528.16339</mixed-citation><mixed-citation xml:lang="en">Mendoza M, Garcia-Ruiz I, Maiz N, et al. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2020;127(11):1374–1380. PMID: 32479682. PMCID: PMC7300912. https://doi.org/10.1111/1471-0528.16339</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17(5):259–260. PMID: 32139904. PMCID: PMC7095524. https://doi.org/10.1038/s41569-020-0360-5</mixed-citation><mixed-citation xml:lang="en">Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17(5):259–260. PMID: 32139904. PMCID: PMC7095524. https://doi.org/10.1038/s41569-020-0360-5</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63(3):364–374. PMID: 32048163. PMCID: PMC7088566. https://doi.org/10.1007/s11427-020-1643-8</mixed-citation><mixed-citation xml:lang="en">Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63(3):364–374. PMID: 32048163. PMCID: PMC7088566. https://doi.org/10.1007/s11427-020-1643-8</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Юлдашева У.О., Курбаниязова В.Э., Идиаминова Г.Н., Собирова С.Э., Аюбова Х.Ш. Врожденные пороки сердца у беременных – современное решение проблемы. Проблемы биологии и медицины. 2015;(4.1):191–195.</mixed-citation><mixed-citation xml:lang="en">Yuldasheva UO, Kurbaniyazova VE, Indiaminova GN, Sobirova SE, Ayubova XSh. Congenital heart defects in pregnant womencontemporary decision of the problem. Problems of Biology and Medicine. 2015;(4.1):191–195. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Breslin N, Baptiste C, Gyamfi-Bannerman C, et al. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM. 2020;2(2):100118. PMID: 32292903. PMCID: PMC7144599. https://doi.org/10.1016/j.ajogmf.2020.100118</mixed-citation><mixed-citation xml:lang="en">Breslin N, Baptiste C, Gyamfi-Bannerman C, et al. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM. 2020;2(2):100118. PMID: 32292903. PMCID: PMC7144599. https://doi.org/10.1016/j.ajogmf.2020.100118</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Theetha Kariyanna P, Sutarjono B, Grewal E, et al. A systematic review of COVID-19 and myocarditis. American Journal of Medical Case Reports. 2020;8(9):299–305. https://doi.org/10.12691/ajmcr-8-9-11.</mixed-citation><mixed-citation xml:lang="en">Theetha Kariyanna P, Sutarjono B, Grewal E, et al. A systematic review of COVID-19 and myocarditis. American Journal of Medical Case Reports. 2020;8(9):299–305. https://doi.org/10.12691/ajmcr-8-9-11.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
