inovmedИнновационная медицина КубаниInnovative Medicine of Kuban2541-9897Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 110.35401/2541-9897-2025-10-1-144-150inovmed-1077Research ArticleОБЗОРЫREVIEWSТерапевтический аферез при раннем развитии преэклампсииTherapeutic Apheresis in Early-Onset Preeclampsia: Literature Reviewhttps://orcid.org/0000-0002-6793-2318ПлахотинаЕ. Н.PlakhotinaElena N.

Плахотина Елена Николаевна, д. м. н., заведующая отделением анестезиологии-реанимации

142700, Московская область, Видное, ул. Заводская, 17

Elena N. Plakhotina, Dr. Sci. (Med.), Head of the Anesthesiology and Intensive Care Unit

ulitsa Zavodskaya 17, Vidnoye, 142700, Moscow Region

https://orcid.org/0000-0003-3804-7691БелоусоваТ. Н.BelousovaTamara N.

Белоусова Тамара Николаевна, к. м. н., главный врач

142700, Московская область, Видное, ул. Заводская, 17

Tamara N. Belousova, Cand. Sci. (Med.), Chief Physician

ulitsa Zavodskaya 17, Vidnoye, 142700, Moscow Region

https://orcid.org/0000-0001-6155-9404БрянцевЕ. В.BryancevEvgenii V.

Брянцев Евгений Владимирович, врач анестезиолог-реаниматолог, отделение анестезиологии-реанимации

142700, Московская область, Видное, ул. Заводская, 17

Evgenii V. Bryancev, Anesthesiologist-Intensivist, Anesthesiology and Intensive Care Unit

ulitsa Zavodskaya 17, Vidnoye, 142700, Moscow Region

https://orcid.org/0009-0007-8649-1566ЧаплыгинаО. В.ChaplyginaOksana V.

Чаплыгина Оксана Владимировна, руководитель отдела анестезиологии и реанимации

Москва

Oksana V. Chaplygina, Head of the Anesthesiology and Intensive Care Unit

Moscow

Видновский перинатальный центрРоссияVidnoye Perinatal CenterRussian FederationМосковский областной НИИ акушерства и гинекологии им. акад. В.И. КраснопольскогоРоссияMoscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. KrasnopolskyRussian Federation202530032025101144150Copyright © Плахотина Е.Н., Белоусова Т.Н., Брянцев Е.В., Чаплыгина О.В., 20252025Плахотина Е.Н., Белоусова Т.Н., Брянцев Е.В., Чаплыгина О.В.Plakhotina E.N., Belousova T.N., Bryancev E.V., Chaplygina O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.innovmedkub.ru/jour/article/view/1077

Преэклампсия представляет собой мультисистемное патологическое состояние, манифестирующее после 20-й недели беременности. Статистика показывает, что преэклампсия является одной из основных причин заболеваемости и смертности матери и плода, особенно при преэклампсии с ранним началом. Около 25% случаев преэклампсии с ранним началом относятся к тяжелым, при этом у 85% беременных при тяжелом течении формируется полиорганная недостаточность. Мертворождение и ранняя неонатальная смертность детей, рожденных женщинами с ранней преэклампсией, на 3–5% выше по сравнению с поздней преэклампсией, асфиксия при рождении диагностируется у 100% детей, инвазивная респираторная поддержка требуется в 80% случаев, каждый четвертый новорожденный имеет проблемы со стороны сердечно-сосудистой и центральной нервной систем.

Анализ публикаций свидетельствует о возможностях пролонгирования беременности при раннем развитии преэклампсии с помощью различных вариантов терапевтического афереза, позволяющих снизить негативные последствия для новорожденных и матерей.

Preeclampsia is a multisystem disorder that manifests after 20 weeks’ gestation. It is a leading cause of maternal and fetal morbidity and mortality. Approximately 25% of early-onset preeclampsia cases are severe, and 85% of pregnant women with severe preeclampsia develop multiple organ failure. Stillbirth and early neonatal mortality in women with early-onset preeclampsia are 3%-5% higher than those in cases of late-onset preeclampsia. Birth asphyxia is diagnosed in 100% of newborns. Invasive respiratory support is required in 80% of cases. Every fourth newborn has cardiovascular and central nervous system issues.

The analyzed literature demonstrated a possibility of pregnancy prolongation in early-onset preeclampsia using different therapeutic apheresis techniques, which can reduce negative consequences for newborns and mothers.

преэклампсия с ранним началомасфиксияинвазивная респираторная поддержкатерапевтический аферезearly-onset preeclampsiabirth asphyxiainvasive respiratory supporttherapeutic apheresisReferencesНургалиева А.Н., Нургалиева Г.Т., Кадыргазина М.К. и др. Ранняя и поздняя преэклампсия: материнские, перинатальные исходы и патоморфологические изменения плаценты. Наука и здравоохранение. 2021;23(5):40–48.Nurgaliyeva AN, Nurgaliyeva GT, Kadyrgazina MK, et al. Early and late preeclampsy: maternal, perinatal outcomes and pathomorphological changes of the placenta. Science & Healthcare. 2021;23(5):40–48. (In Russ.).Замалеева Р.С., Черепанова Н.А., Фризина А.В., Юпатов Е.Ю., Фризин Д.В. Возможности прогнозирования плацента-ассоциированной патологии во втором триместре беременности с помощью шкалы балльной оценки риска и кардиотокографии плода. Вопросы гинекологии, акушерства и перинатологии. 2020;19(5):36–43. https://doi.org/10.20953/1726-1678-2020-5-36-43Zamaleeva RS, Cherepanova NA, Frizina AV, Yupatov EYu, Frizin DV. Prediction of placental pathology during the second trimester of pregnancy using a new risk assessment scale and fetal cardiotocography. Gynecology, Obstetrics and Perinatology. 2020;19(5):36– 43. (In Russ.). https://doi.org/10.20953/1726-1678-2020-5-36-43Ковтун О.П., Цывьян П.Б. Преэклампсия матери и программирование сердечно-сосудистого здоровья ребенка. Российский вестник перинатологии и педиатрии. 2019;64(4):19– 25. https://doi.org/10.21508/1027-4065-2019-64-4-19-25Kovtun OP, Tsyvian PB. Pre-eclampsia in a mother and programming of the child’s cardiovascular health. Rossiyskiy vestnik perinatologii i pediatrii. 2019;64(4):19–25. (In Russ.). https://doi.org/10.21508/1027-4065-2019-64-4-19-25Кинжалова С.В., Макаров Р.А., Давыдова Н.С., Бычкова С.В., Пестряева Л.А. Перинатальные исходы при абдоминальном родоразрешении беременных с тяжелой преэклампсией в условиях общей и спинальной анестезии. Анестезиология и реаниматология. 2018;(5):36–43. https://doi.org/10.17116/anaesthesiology201805136Kinzhalova SV, Makarov RA, Davydova NS, Bychkova SV, Pestryaeva LA. Perinatal outcomes in pregnant women with severe preeclampsia in abdominal delivery under general and spinal anesthesia. Russian Journal of Anaesthesiology and Reanimatology. 2018;(5):36–43. (In Russ.). https://doi.org/10.17116/anaesthesiology201805136Ukah UV, De Silva DA, Payne B, et al. Prediction of adverse maternal outcomes from pre-eclampsia and other hypertensive disorders of pregnancy: a systematic review. Pregnancy Hypertens. 2018;11:115–123. PMID: 29198742. https://doi.org/10.1016/j.preghy.2017.11.006Ukah UV, De Silva DA, Payne B, et al. Prediction of adverse maternal outcomes from pre-eclampsia and other hypertensive disorders of pregnancy: a systematic review. Pregnancy Hypertens. 2018;11:115–123. PMID: 29198742. https://doi.org/10.1016/j.preghy.2017.11.006Ходжаева З.С., Ошхунова М.С., Муминова К.Т., Горина К.А., Холин А.М. Прогнозирование и ранняя диагностика преэклампсии: научные перспективы и клинические возможности. Акушерство и гинекология. 2022;(12):57–65. https://doi.org/10.18565/aig.2022.218Khodzhaeva ZS, Oshkhunova MS, Muminova KT, Gorina KA, Kholin AM. Prediction and early diagnosis of preeclampsia: scientific perspectives and clinical opportunities. Akusherstvo i ginekologiia. 2022;(12):57–65. (In Russ.). https://doi.org/10.18565/aig.2022.218Lisonkova S, Joseph KS. Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease. Am J Obstet Gynecol. 2013;209(6):544.e1–544.e12. PMID: 23973398. https://doi.org/10.1016/j.ajog.2013.08.019Lisonkova S, Joseph KS. Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease. Am J Obstet Gynecol. 2013;209(6):544.e1–544.e12. PMID: 23973398. https://doi.org/10.1016/j.ajog.2013.08.019Тимофеева Л.А., Караваева А.Л., Зубков В.В., Киртбая А.Р., Кан Н.Е., Тютюнник В.Л. Роль преэклампсии в исходах беременности: взгляд неонатолога. Акушерство и гинекология. 2019;(4):73–78. https://doi.org/10.18565/aig.2019.4.73-78Timofeeva LA, Karavaeva AL, Zubkov VV, Kirtbaya AR, Kan NE, Tyutyunnik VL. The role of preeclampsia in pregnancy outcomes: the view of a neonatologist. Akusherstvo i ginekologiia. 2019;(4):73–78. (In Russ.). https://doi.org/10.18565/aig.2019.4.73-78Rocha G. Consequences of early-onset preeclampsia on neonatal morbidity and mortality. Minerva Pediatr (Torino). 2023;75(1):87–97. PMID: 35373936. https://doi.org/10.23736/S2724-5276.22.06714-3Rocha G. Consequences of early-onset preeclampsia on neonatal morbidity and mortality. Minerva Pediatr (Torino). 2023;75(1):87–97. PMID: 35373936. https://doi.org/10.23736/S2724-5276.22.06714-3van Esch JJA, van Heijst AF, de Haan AFJ, van der Heijden OWH. Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity. J Matern Fetal Neonatal Med. 2017;30(23):2789–2794. PMID: 28282780. https://doi.org/10.1080/14767058.2016.1263295van Esch JJA, van Heijst AF, de Haan AFJ, van der Heijden OWH. Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity. J Matern Fetal Neonatal Med. 2017;30(23):2789–2794. PMID: 28282780. https://doi.org/10.1080/14767058.2016.1263295Monier I, Ancel PY, Ego A, et al; EPIPAGE 2 Study Group. Gestational age at diagnosis of early-onset fetal growth restriction and impact on management and survival: a population-based cohort study. BJOG. 2017;124(12):1899–1906. PMID: 28266776. https://doi.org/10.1111/1471-0528.14555Monier I, Ancel PY, Ego A, et al; EPIPAGE 2 Study Group. Gestational age at diagnosis of early-onset fetal growth restriction and impact on management and survival: a population-based cohort study. BJOG. 2017;124(12):1899–1906. PMID: 28266776. https://doi.org/10.1111/1471-0528.14555Шахбазова Н.А. Перинатальные исходы на фоне различных методов профилактики гипертензивных расстройств при беременности. Российский вестник перинатологии и педиатрии. 2018;63(3):45–50. https://doi.org/10.21508/1027-4065-2018-63-3-45-50Shakhbazova NA. Perinatal outcomes in cases with various methods of prevention of hypertensive disorders during pregnancy. Rossiyskiy vestnik perinatologii i pediatrii. 2018;63(3):45–50. (In Russ.). https://doi.org/10.21508/1027-4065-2018-63-3-45-50Zamir M, Nelson DM, Ginosar Y. Hemodynamic consequences of incomplete uterine spiral artery transformation in human pregnancy, with implications for placental dysfunction and preeclampsia. J Appl Physiol (1985). 2021;130(2):457– 465. Published correction appears in J Appl Physiol (1985). 2021;130(5):1351. PMID: 33356980. https://doi.org/10.1152/japplphysiol.00504.2020Zamir M, Nelson DM, Ginosar Y. Hemodynamic consequences of incomplete uterine spiral artery transformation in human pregnancy, with implications for placental dysfunction and preeclampsia. J Appl Physiol (1985). 2021;130(2):457– 465. Published correction appears in J Appl Physiol (1985). 2021;130(5):1351. PMID: 33356980. https://doi.org/10.1152/japplphysiol.00504.2020Абрамова М.Ю., Чурносов М.И. Современные представления об этиологии, патогенезе и факторах риска преэклампсии. Журнал акушерства и женских болезней. 2021;70(5):105–116. https://doi.org/10.17816/jowd77046Abramova MYu, Churnosov MI. Modern concepts of etiology, pathogenesis and risk factors for preeclampsia. Journal of Obstetrics and Women’s Diseases. 2021;70(5):105–116. (In Russ.). https://doi.org/10.17816/jowd77046Панова И.А., Кудряшова А.В., Рокотянская Е.А., Малышкина А.И. Особенности эластических свойств сосудов и иммунного воспалительного ответа при гипертензивных расстройствах у беременных. Российский вестник акушера-гинеколога. 2019;19(1):18–26. https://doi.org/10.17116/rosakush20191901118Panova IA, Kudryashova AV, Rokotyanskaya EA, Malyshkina AI. The characteristics of vascular elastic properties and the immune inflammatory response in pregnant women with hypertension. Rossiiskii vestnik akushera-ginekologa. 2019;19(1):18–26. (In Russ.). https://doi.org/10.17116/rosakush20191901118Стрюк Р.И., Бухонкина Ю.М., Смирнова В.А., Чижова Г.В. Функция эндотелия и маточно-плодово-плацентарный кровоток у беременных с артериальной гипертонией. Кардиология. 2010;50(4):18–22. PMID: 20459416.Striuk RI, Bukhonkina IuM, Smirnova VA, Chizhova GV. Function of endothelium and feto-utero-placental blood flow in pregnant women with arterial hypertension. Kardiologiia. 2010;50(4):18–22. (In Russ.). PMID: 20459416.Jena MK, Sharma NR, Petitt M, Maulik D, Nayak NR. Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta. Biomolecules. 2020;10(6):953. PMID: 32599856. PMCID: PMC7357118. https://doi.org/10.3390/biom10060953Jena MK, Sharma NR, Petitt M, Maulik D, Nayak NR. Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta. Biomolecules. 2020;10(6):953. PMID: 32599856. PMCID: PMC7357118. https://doi.org/10.3390/biom10060953Gupta AK, Hasler P, Holzgreve W, Gebhardt S, Hahn S. Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia. Hum Immunol. 2005;66(11):1146–1154. PMID: 16571415. https://doi.org/10.1016/j.humimm.2005.11.003Gupta AK, Hasler P, Holzgreve W, Gebhardt S, Hahn S. Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia. Hum Immunol. 2005;66(11):1146–1154. PMID: 16571415. https://doi.org/10.1016/j.humimm.2005.11.003Gupta AK, Rusterholz C, Huppertz B, et al. A comparative study of the effect of three different syncytiotrophoblast micro-particles preparations on endothelial cells. Placenta. 2005;26(1):59–66. PMID: 15664412. https://doi.org/10.1016/j.placenta.2004.04.004Gupta AK, Rusterholz C, Huppertz B, et al. A comparative study of the effect of three different syncytiotrophoblast micro-particles preparations on endothelial cells. Placenta. 2005;26(1):59–66. PMID: 15664412. https://doi.org/10.1016/j.placenta.2004.04.004Gupta A, Hasler P, Gebhardt S, Holzgreve W, Hahn S. Occurrence of neutrophil extracellular DNA traps (NETs) in preeclampsia: a link with elevated levels of cell-free DNA?. Ann N Y Acad Sci. 2006;1075:118–122. PMID: 17108200. https://doi.org/10.1196/annals.1368.015Gupta A, Hasler P, Gebhardt S, Holzgreve W, Hahn S. Occurrence of neutrophil extracellular DNA traps (NETs) in preeclampsia: a link with elevated levels of cell-free DNA?. Ann N Y Acad Sci. 2006;1075:118–122. PMID: 17108200. https://doi.org/10.1196/annals.1368.015Gupta AK, Hasler P, Holzgreve W, Hahn S. Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?. Semin Immunopathol. 2007;29(2):163–167. PMID: 17621701. https://doi.org/10.1007/s00281-007-0073-4Gupta AK, Hasler P, Holzgreve W, Hahn S. Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?. Semin Immunopathol. 2007;29(2):163–167. PMID: 17621701. https://doi.org/10.1007/s00281-007-0073-4Kraemer BF, Hennis I, Karge A, et al. Platelet mitochondrial membrane depolarization reflects disease severity in patients with preeclampsia. Mol Med. 2022;28(1):51. PMID: 35508969. PMCID: PMC9066965. https://doi.org/10.1186/s10020-022-00472-xKraemer BF, Hennis I, Karge A, et al. Platelet mitochondrial membrane depolarization reflects disease severity in patients with preeclampsia. Mol Med. 2022;28(1):51. PMID: 35508969. PMCID: PMC9066965. https://doi.org/10.1186/s10020-022-00472-xMaynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111(5):649–658. PMID: 12618519. PMCID: PMC151901. https://doi.org/10.1172/JCI17189Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111(5):649–658. PMID: 12618519. PMCID: PMC151901. https://doi.org/10.1172/JCI17189Rana S, Schnettler WT, Powe C, et al. Clinical characterization and outcomes of preeclampsia with normal angiogenic profile. Hypertens Pregnancy. 2013;32(2):189–201. PMID: 23725084. PMCID: PMC3744824. https://doi.org/10.3109/10641955.2013.784788Rana S, Schnettler WT, Powe C, et al. Clinical characterization and outcomes of preeclampsia with normal angiogenic profile. Hypertens Pregnancy. 2013;32(2):189–201. PMID: 23725084. PMCID: PMC3744824. https://doi.org/10.3109/10641955.2013.784788Иванец Т.Ю., Алексеева М.Л., Кан Н.Е. и др. Диагностическая значимость определения плацентарного фактора роста и растворимой fms-подобной тирозинкиназы-1 в качестве маркеров преэклампсии. Проблемы репродукции. 2015;21(4):129– 133. https://doi.org/10.17116/repro2015214129-133Ivanets TYu, Alekseeva ML, Kan NE, et al. Diagnostic value of placental growth factor and soluble fms-like tyrosine kinase-1 as pre-eclampsia markers. Problemy reproduktsii. 2015;21(4):129– 133. (In Russ.). https://doi.org/10.17116/repro2015214129-133Курцер М.А., Шаманова М.Б., Синицина О.В., Николаева А.А., Дедловская А.И., Самсонова М.А. Клиническое обоснование определения соотношения sFlt-1/PlGF с целью раннего выявления и оценки степени тяжести преэклампсии. Акушерство и гинекология. 2018;(11):114–120. https://doi.org/10.18565/aig.2018.11.114-120Kurtser MA, Shamanova MB, Sinitsina OV, Nikolaeva AA, Dedlovskaya AI, Samsonova MA. Clinical rationale for determining the ratio sFlt-1/PlGF for the early detection and evaluation of the severity of preeclampsia. Akusherstvo i ginekologiia. 2018;(11):114–120. (In Russ.). https://doi.org/10.18565/aig.2018.11.114-120Nikuei P, Rajaei M, Roozbeh N, et al. Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia. BMC Pregnancy Childbirth. 2020;20(1):80. PMID: 32033594. PMCID: PMC7006116. https://doi.org/10.1186/s12884-020-2744-2Nikuei P, Rajaei M, Roozbeh N, et al. Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia. BMC Pregnancy Childbirth. 2020;20(1):80. PMID: 32033594. PMCID: PMC7006116. https://doi.org/10.1186/s12884-020-2744-2Verlohren S, Brennecke SP, Galindo A, et al. Clinical interpretation and implementation of the sFlt-1/PlGF ratio in the prediction, diagnosis and management of preeclampsia. Pregnancy Hypertens. 2022;27:42–50. PMID: 34915395. https://doi.org/10.1016/j.preghy.2021.12.003Verlohren S, Brennecke SP, Galindo A, et al. Clinical interpretation and implementation of the sFlt-1/PlGF ratio in the prediction, diagnosis and management of preeclampsia. Pregnancy Hypertens. 2022;27:42–50. PMID: 34915395. https://doi.org/10.1016/j.preghy.2021.12.003El-Sayed AAF. Preeclampsia: a review of the pathogenesis and possible management strategies based on its pathophysiological derangements. Taiwan J Obstet Gynecol. 2017;56(5):593–598. PMID: 29037542. https://doi.org/10.1016/j.tjog.2017.08.004El-Sayed AAF. Preeclampsia: a review of the pathogenesis and possible management strategies based on its pathophysiological derangements. Taiwan J Obstet Gynecol. 2017;56(5):593–598. PMID: 29037542. https://doi.org/10.1016/j.tjog.2017.08.004Thadhani R, Hagmann H, Schaarschmidt W, et al. Removal of soluble fms-like tyrosine kinase-1 by dextran sulfate apheresis in preeclampsia. J Am Soc Nephrol. 2016;27(3):903–913. PMID: 26405111. PMCID: PMC4769204. https://doi.org/10.1681/ ASN.2015020157Thadhani R, Hagmann H, Schaarschmidt W, et al. Removal of soluble fms-like tyrosine kinase-1 by dextran sulfate apheresis in preeclampsia. J Am Soc Nephrol. 2016;27(3):903–913. PMID: 26405111. PMCID: PMC4769204. https://doi.org/10.1681/ ASN.2015020157Gubensek J, Ponikvar R, Premru Srsen T, Fabjan Vodusek V, Moertl MG, Lucovnik M. Therapeutic plasma exchange and dextran-sulfate plasma adsorption as extracorporeal treatments of extremely preterm preeclampsia with fetal growth restriction. J Clin Apher. 2021;36(4):595–605. PMID: 33847403. https://doi.org/10.1002/jca.21899Gubensek J, Ponikvar R, Premru Srsen T, Fabjan Vodusek V, Moertl MG, Lucovnik M. Therapeutic plasma exchange and dextran-sulfate plasma adsorption as extracorporeal treatments of extremely preterm preeclampsia with fetal growth restriction. J Clin Apher. 2021;36(4):595–605. PMID: 33847403. https://doi.org/10.1002/jca.21899Ertorer ME, Guvenc B, Haydardedeoglu B, Tekinturhan F. A case report of the cascade filtration system: a safe and effective method for low-density lipoprotein apheresis during pregnancy. Ther Apher Dial. 2008;12(5):396–400. PMID: 18937724. https://doi.org/10.1111/j.1744-9987.2008.00616.xErtorer ME, Guvenc B, Haydardedeoglu B, Tekinturhan F. A case report of the cascade filtration system: a safe and effective method for low-density lipoprotein apheresis during pregnancy. Ther Apher Dial. 2008;12(5):396–400. PMID: 18937724. https://doi.org/10.1111/j.1744-9987.2008.00616.xRonco C, Bellomo R. Hemoperfusion: technical aspects and state of the art. Crit Care. 2022;26(1):135. PMID: 35549999. PMCID: PMC9097563. https://doi.org/10.1186/s13054-022-04009-wRonco C, Bellomo R. Hemoperfusion: technical aspects and state of the art. Crit Care. 2022;26(1):135. PMID: 35549999. PMCID: PMC9097563. https://doi.org/10.1186/s13054-022-04009-wThadhani R, Kisner T, Hagmann H, et al. Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia. Circulation. 2011;124(8):940–950. PMID: 21810665. https://doi.org/10.1161/CIRCULATIONAHA.111.034793Thadhani R, Kisner T, Hagmann H, et al. Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia. Circulation. 2011;124(8):940–950. PMID: 21810665. https://doi.org/10.1161/CIRCULATIONAHA.111.034793Tang XD, Ji TT, Dong JR, et al. Pathogenesis and treatment of cytokine storm induced by infectious diseases. Int J Mol Sci. 2021;22(23):13009. PMID: 34884813. PMCID: PMC8658039. https://doi.org/10.3390/ijms222313009Tang XD, Ji TT, Dong JR, et al. Pathogenesis and treatment of cytokine storm induced by infectious diseases. Int J Mol Sci. 2021;22(23):13009. PMID: 34884813. PMCID: PMC8658039. https://doi.org/10.3390/ijms222313009Stefańska K, Zieliński M, Jankowiak M, et al. Cytokine imprint in preeclampsia. Front Immunol. 2021;12:667841. PMID: 34248946. PMCID: PMC8261231. https://doi.org/10.3389/fimmu.2021.667841Stefańska K, Zieliński M, Jankowiak M, et al. Cytokine imprint in preeclampsia. Front Immunol. 2021;12:667841. PMID: 34248946. PMCID: PMC8261231. https://doi.org/10.3389/fimmu.2021.667841Pinheiro MB, Martins-Filho OA, Mota AP, et al. Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state. Cytokine. 2013;62(1):165– 173. PMID: 23523008. https://doi.org/10.1016/j.cyto.2013.02.027Pinheiro MB, Martins-Filho OA, Mota AP, et al. Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state. Cytokine. 2013;62(1):165– 173. PMID: 23523008. https://doi.org/10.1016/j.cyto.2013.02.027Кутепов Д.Е., Пасечник И.Н., Вершинина М.Г. Современные возможности лечения сепсиса на основе сорбционных методик (обзор литературы). Лабораторная служба. 2019;8(4):22–28. https://doi.org/10.17116/labs2019804122Kutepov DE, Pasechnik IN, Vershinina MG. Current treatment options for sepsis based on sorption methods (review). Laboratornaya sluzhba. 2019;8(4):22–28. (In Russ.). https://doi.org/10.17116/labs2019804122Lorenzin A, Neri M, de Cal M, et al. Fluid dynamics analysis by CT imaging technique of new sorbent cartridges for extracorporeal therapies. Blood Purif. 2019;48(1):18–24. PMID: 31039563. https://doi.org/10.1159/000499076Lorenzin A, Neri M, de Cal M, et al. Fluid dynamics analysis by CT imaging technique of new sorbent cartridges for extracorporeal therapies. Blood Purif. 2019;48(1):18–24. PMID: 31039563. https://doi.org/10.1159/000499076Szczepiorkowski ZM. Indications for therapeutic apheresis in hematological disorders. Semin Hematol. 2020;57(2):57–64. PMID: 32892844. https://doi.org/10.1053/j.seminhematol.2020.07.008Szczepiorkowski ZM. Indications for therapeutic apheresis in hematological disorders. Semin Hematol. 2020;57(2):57–64. PMID: 32892844. https://doi.org/10.1053/j.seminhematol.2020.07.008Белоцерковцева Л.Д., Коваленко Л.В., Панкратов В.В., Зинин В.Н. Ранняя преэклампсия и возможность пролонгирования беременности с точки зрения патогенетического подхода. Общая реаниматология. 2022;18(2):37–44. https://doi.org/10.15360/1813-9779-2022-2-37-44Belotserkovtseva LD, Kovalenko LV, Pankratov VV, Zinin VN. Pathogenetic approach to early preeclampsia and the feasibility of pregnancy prolongation. General Reanimatology. 2022;18(2):37– 44. (In Russ.). https://doi.org/10.15360/1813-9779-2022-2-37-44Белоцерковцева Л.Д., Зинин В.Н., Коваленко Л.В., Панкратов В.В., Исаев Т.И. Опыт применения каскадной плазмофильтрации при ранней преэклампсии. Вопросы гинекологии, акушерства и перинатологии. 2020;19(5):140–146. https://doi.org/10.20953/1726-1678-2020-5-140-146Belotserkovtseva LD, Zinin VN, Kovalenko LV, Pankratov VV, Isaev TI. Cascade filtration plasmapheresis for early preeclampsia: our experience. Gynecology, Obstetrics and Perinatology. 2020;19(5):140–146. (In Russ.). https://doi.org/10.20953/1726-1678-2020-5-140-146Padmanabhan A, Connelly-Smith L, Aqui N, et al. Guidelines on the use of therapeutic apheresis in clinical practice - evidence-based approach from the Writing Committee of the American Society for Apheresis: the eighth special issue. J Clin Apher. 2019;34(3):171–354. PMID: 31180581. https://doi.org/10.1002/jca.21705PadmanabhanA, Connelly-Smith L, Aqui N, et al. Guidelines on the use of therapeutic apheresis in clinical practice - evidence-based approach from the Writing Committee of the American Society for Apheresis: the eighth special issue. J Clin Apher. 2019;34(3):171–354. PMID: 31180581. https://doi.org/10.1002/jca.21705Iannaccone A, Reisch B, Kimmig R, et al. Therapeutic plasma exchange in early-onset preeclampsia: a 7-year monocentric experience. J Clin Med. 2023;12(13):4289. PMID: 37445324. PMCID: PMC10342637. https://doi.org/10.3390/jcm12134289Iannaccone A, Reisch B, Kimmig R, et al. Therapeutic plasma exchange in early-onset preeclampsia: a 7-year monocentric experience. J Clin Med. 2023;12(13):4289. PMID: 37445324. PMCID: PMC10342637. https://doi.org/10.3390/jcm12134289Trapiella-Alfonso L, Alexandre L, Fraichard C, et al. VEGF (vascular endothelial growth factor) functionalized magnetic beads in a microfluidic device to improve the angiogenic balance in preeclampsia. Hypertension. 2019;74(1):145–153. PMID: 31079531. https://doi.org/10.1161/HYPERTENSIONAHA.118.12380Trapiella-Alfonso L, Alexandre L, Fraichard C, et al. VEGF (vascular endothelial growth factor) functionalized magnetic beads in a microfluidic device to improve the angiogenic balance in preeclampsia. Hypertension. 2019;74(1):145–153. PMID: 31079531. https://doi.org/10.1161/HYPERTENSIONAHA.118.12380Rduch T, Arn N, Kinkel J, et al. Magnetic blood purification-based soluble fms-like tyrosine kinase-1 removal in comparison with dextran sulfate apheresis and therapeutic plasma exchange. Artif Organs. 2023;47(8):1309–1318. PMID: 36995348. https://doi.org/10.1111/aor.14531.Rduch T, Arn N, Kinkel J, et al. Magnetic blood purification-based soluble fms-like tyrosine kinase-1 removal in comparison with dextran sulfate apheresis and therapeutic plasma exchange. Artif Organs. 2023;47(8):1309–1318. PMID: 36995348. https://doi.org/10.1111/aor.14531.

The authors declare that there are no conflicts of interest present.