<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2541-9897-2025-10-4-136-144</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-1383</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Метод ближней инфракрасной спектроскопии как помощник в предотващении гипоксических осложнений у детей</article-title><trans-title-group xml:lang="en"><trans-title>Near-Infrared Spectroscopy as a Tool for Preventing Hypoxic Complications in Children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-6499-012X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клейменов</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kleymenov</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Клейменов Кирилл Александрович, врач анестезиолог-реаниматолог </p><p>650066, Кемерово, пр-т Октябрьский, 22 </p></bio><bio xml:lang="en"><p>Kirill A. Kleymenov, Anesthesiologist Intensivist </p><p>Oktyabrsky Avenue 22, Kemerovo, 650066 </p></bio><email xlink:type="simple">k.kleymenov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8370-3083</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорьев</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigoriev</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Григорьев Евгений Валерьевич, д. м. н., профессор РАН, заместитель директора по научной и лечебной работе </p><p>Кемерово </p></bio><bio xml:lang="en"><p>Evgeny V. Grigoriev, Dr Sci. (Med.), Professor of the Russian Academy of Sciences, Deputy Director for Scientific and Medical Affairs </p><p>Kemerovo </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5993-2027</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каменева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kameneva</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каменева Евгения Александровна, д. м. н., врач анестезиолог-реаниматолог, главный врач </p><p>Кемерово </p></bio><bio xml:lang="en"><p>Evgeniya A. Kameneva, Dr. Sci. (Med.), Anesthesiologist Intensivist, Chief Physician </p><p>Kemerovo </p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3269-9018</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мозес</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Mozes</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мозес Вадим Гельевич, д. м. н., профессор, заместитель главного врача по научной деятельности </p><p>Кемерово </p></bio><bio xml:lang="en"><p>Vadim G. Mozes, Dr. Sci. (Med.), Professor, Deputy Chief Physician for Scientific Affairs </p><p>Kemerovo </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6599-9906</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рудаева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudaeva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рудаева Елена Владимировна, к. м. н., доцент, доцент кафедры акушерства и гинекологии им. Г.А. Ушаковой </p><p>Кемерово </p></bio><bio xml:lang="en"><p>Elena V. Rudaeva, Cand. Sci. (Med.), Associate Professor, Department of Obstetrics and Gynecology named after Prof. G.A. Usha­ kova </p><p>Kemerovo </p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6966-2681</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елгина</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Elgina</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елгина Светлана Ивановна, д. м. н., доцент, профессор кафедры акушерства и гинекологии им. Г.А. Ушаковой </p><p>Кемерово </p></bio><bio xml:lang="en"><p>Svetlana I. Elgina, Dr. Sci. (Med.), Associate Professor, Department of Obstetrics and Gynecology named after Prof. G.A. Ushakova </p><p>Kemerovo </p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2906-6217</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мозес</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Mozes</surname><given-names>K. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мозес Кира Борисовна, ассистент кафедры поликлинической терапии и сестринского дела </p><p>Кемерово </p></bio><bio xml:lang="en"><p>Mozes Kira Borisovna, Assistant Professor, Department of Outpatient Therapy, Postgraduate Training and Nursing </p><p>Kemerovo </p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кузбасская областная клиническая больница им. С.В. Беляева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuzbass Regional Clinical Hospital named after S.V. Belyaeva</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Complex Issues of Cardiovascular Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Кузбасская клиническая больница скорой медицинской помощи им. М.А. Подгорбунского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuzbass Clinical Hospital of Emergency Medical Care named after M.A. Podgorbunsky</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Кемеровский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kemerovo State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2025</year></pub-date><volume>10</volume><issue>4</issue><fpage>136</fpage><lpage>144</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Клейменов К.А., Григорьев Е.В., Каменева Е.А., Мозес В.Г., Рудаева Е.В., Елгина С.И., Мозес К.Б., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Клейменов К.А., Григорьев Е.В., Каменева Е.А., Мозес В.Г., Рудаева Е.В., Елгина С.И., Мозес К.Б.</copyright-holder><copyright-holder xml:lang="en">Kleymenov K.A., Grigoriev E.V., Kameneva E.A., Mozes V.G., Rudaeva E.V., Elgina S.I., Mozes K.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/1383">https://www.innovmedkub.ru/jour/article/view/1383</self-uri><abstract><p>Гипоксия является частым осложнением критического состояния в неонатологии и педиатрии и приводит к нарушению окислительных процессов, развитию ацидоза, снижению энергетического баланса клетки, избытку нейромедиаторов, нарушению метаболизма глии и нейронов. Не менее актуальной является проблема профилактики гипоксического поражения головного мозга при анестезиологическом обеспечении. </p><p>Одним из перспективных направлений, позволяющих врачам минимизировать риски осложнений, становится мониторинг церебральной гемодинамики, включая использование технологии ближней инфракрасной спектроскопии (NIRS). Этот метод позволяет неинвазивно оценивать региональную насыщенность кислородом тканей мозга, что теоретически помогает врачам анестезиологам-реаниматологам предотвращать развитие гипоксических нарушений у пациентов детского возраста. Каждая применяемая методика имеет достоинства и недостатки. Среди минусов NIRS можно выделить отсутствие четких диагностических критериев и недостаточно обоснованных доказательств, подтверждающих эффективность и значимость метода для улучшения краткосрочных и долгосрочных результатов лечения. Несмотря на это, принцип измерения, основанный на законе Ламберта-Бера, наряду с многочисленными публикациями и исследованиями, создает прочную основу для дальнейших научных изысканий, направленных на разработку подходов по оптимизации мониторинга и своевременной коррекции гипоксических и ишемических изменений мозга посредством NIRS-контроля церебрального кислородоснабжения. </p></abstract><trans-abstract xml:lang="en"><p>Hypoxia is a common complication of critical conditions in neonatology and pediatrics, leading to impaired oxidative processes, development of acidosis, decreased cellular energy balance, excessive neurotransmitters, disruption of glial and neuronal metabolism. Equally important is the prevention of hypoxic brain injury during anesthesia. A promising and actively developing approach that allows physicians to manage anesthetic risks is the assessment of cerebral hemodynamics, particularly through the use of near-infrared spectroscopy. This method enables non-invasive monitoring of regional cerebral oxygenation, which at least theoretically, may help  anesthesiologists and intensivists prevent hypoxic complications in children. Each method used in clinical practice has its advantages and disadvantages. One of the limitations of near-infrared spectroscopy is the lack of clearly defined diagnostic criteria and the insufficient evidence supporting its efficacy and clinical relevance in improving postoperative outcomes in both the short and long term. Nevertheless, measurements based on the Beer-Lambert law, supported by numerous publications and studies, provides a reliable foundation for further research afocused on improving monitoring strategies and timely correction of hypoxic and ishemic cerebral brain changes through NIRS-based cerebral oxygenation monitoring. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипоксическое поражение</kwd><kwd>головной мозг</kwd><kwd>церебральная гемодинамика</kwd><kwd>анестезия</kwd><kwd>Near-infrared spectroscopy</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypoxic injury</kwd><kwd>brain</kwd><kwd>cerebral hemodynamics</kwd><kwd>anesthesia</kwd><kwd>near-infrared spectroscopy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Снисарь В.И., Павлыш А.С. Неинвазивный мониторинг церебральной оксиметрии у детей. Медицина неотложных состояний. 2018;6(93):35-41. https://doi.org/10.22141/2224-0586.6.93.2018.147640</mixed-citation><mixed-citation xml:lang="en">Snisar VI, Pavlysh OS. Non-Invasive Monitoring of Cerebral Oximetry in Children. EMERGENCY MEDICINE. 2018;6(93):35-41. (In Russ.). https://doi.org/10.22141/2224-0586.6.93.2018.147640</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrari M, Giannini I, Sideri G, Zanette E. Continuous non invasive monitoring of human brain by near infrared spectroscopy. Adv Exp Med Biol. 1985;191:873-882. PMID: 3008520. https://doi.org/10.1007/978-1-4684-3291-6_88</mixed-citation><mixed-citation xml:lang="en">Ferrari M, Giannini I, Sideri G, Zanette E. Continuous non invasive monitoring of human brain by near infrared spectroscopy. Adv Exp Med Biol. 1985;191:873-882. PMID: 3008520. https:// doi.org/10.1007/978-1-4684-3291-6_88</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wolfberg AJ, du Plessis AJ. Near-infrared spectroscopy in the fetus and neonate. Clin Perinatol. 2006;33(3):707-viii. PMID: 16950321. https://doi.org/10.1016/j.clp.2006.06.010</mixed-citation><mixed-citation xml:lang="en">Wolfberg AJ, du Plessis AJ. Near-infrared spectroscopy in the fetus and neonate. Clin Perinatol. 2006;33(3):707-viii. PMID: 16950321. https://doi.org/10.1016/j.clp.2006.06.010</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sood BG, McLaughlin K, Cortez J. Near-infrared spectroscopy: applications in neonates. Semin Fetal Neonatal Med. 2015;20(3):164-172. PMID: 25934116. https://doi.org/10.1016/j.siny.2015.03.008</mixed-citation><mixed-citation xml:lang="en">Sood BG, McLaughlin K, Cortez J. Near-infrared spectroscopy: applications in neonates. Semin Fetal Neonatal Med. 2015;20(3):164-172. PMID: 25934116. https://doi.org/10.1016/j. siny.2015.03.008</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Тебердиева С.О., Ушакова Л.В., Буров А.А., Киртбая А.Р., Крючко Д.С. Клинико-прогностическая ценность церебральной оксиметрии у новорожденных с врожденными пороками развития в периоперационном периоде. Неонатология: новости, мнения, обучение. 2017;4(18):88-95. https://doi.org/10.24411/2308-2402-2017-00008</mixed-citation><mixed-citation xml:lang="en">Teberdieva SO, Ushakova LV, Burov AA, Kirtbaya AR, Kryuchko DS. Clinical and prognostic value of cerebral oximetry in newborns with congenital malformations in the perioperative period. Neonatology: news, views, education. 2017;4(18):88-95. (In Russ.) https://doi.org/10.24411/2308-2402-2017-00008</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bansal V, Smischney NJ, Kashyap R, et al. Reintubation Summation Calculation: A Predictive Score for Extubation Failure in Critically Ill Patients. Front Med (Lausanne). 2022;8:789440. PMID: 35252224. PMCID: PMC8891541. https://doi.org/10.3389/fmed.2021.789440</mixed-citation><mixed-citation xml:lang="en">Bansal V, Smischney NJ, Kashyap R, et al. Reintubation Summation Calculation: A Predictive Score for Extubation Failure in Critically Ill Patients. Front Med (Lausanne). 2022;8:789440. PMID: 35252224. PMCID: PMC8891541. https://doi.org/10.3389/fmed.2021.789440</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Tsou PY, Garcia AV, Yiu A, Vaidya DM, Bembea MM. Association of Cerebral Oximetry with Outcomes after Extracorporeal Membrane Oxygenation. Neurocrit Care. 2020;33(2):429-437. PMID: 31925732. PMCID: PMC7842183. https://doi.org/10.1007/s12028-019-00892-4</mixed-citation><mixed-citation xml:lang="en">Tsou PY, Garcia AV, Yiu A, Vaidya DM, Bembea MM. Association of Cerebral Oximetry with Outcomes after Extracorporeal Membrane Oxygenation. Neurocrit Care. 2020;33(2):429-437. PMID: 31925732. PMCID: PMC7842183. https://doi.org/10.1007/s12028-019-00892-4</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Александрович Ю.С., Пшениснов К.В. Мониторинг кислородного статуса при критических состояниях у детей. Тольяттинский медицинский консилиум. 2011;5-6:7-13.</mixed-citation><mixed-citation xml:lang="en">Alexandrovich YS, Pshenisnov KV. Monitoring of oxygen status of children in critical state. Toljattinskij medicinskij konsilium.2011;5-6:7-13. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.А., Александров А.Е., Шарков С.М. Возрастные особенности церебральной оксиметрии у детей. Российский педиатрический журнал. 2012;5:17-19.</mixed-citation><mixed-citation xml:lang="en">Alekseeva EA, Aleksandrov AE, Sharkov SM. Developmental features of cerebral oximetry in children. Russian pediatric journal. 2012;5:17-19. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.А., Александров А.Е., Шарков С.М. Кислородный статус головного мозга у детей в интра- и послеоперационном периоде при проведении ингаляционной анестезии. Детская хирургия. 2014;18(4):32-34.</mixed-citation><mixed-citation xml:lang="en">Alekseeva EA, Aleksandrov AE, Sharkov SM. Brain oxygen status in children in the intra and postoperative period associated with inhalation anesthesia. Russian journal of pediatric surgery. 2014;18(4):32-34. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Vedrenne-Cloquet M, Lévy R, Chareyre J, et al. Association of Cerebral Oxymetry with Short-Term Outcome in Critically ill Children Undergoing Extracorporeal Membrane Oxygenation.</mixed-citation><mixed-citation xml:lang="en">Vedrenne-Cloquet M, Lévy R, Chareyre J, et al. Association of Cerebral Oxymetry with Short-Term Outcome in Critically ill Children Undergoing Extracorporeal Membrane Oxygenation.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Neurocrit Care. 2021;35(2):409-417. PMID: 33432528. https://doi.org/10.1007/s12028-020-01179-9</mixed-citation><mixed-citation xml:lang="en">Neurocrit Care. 2021;35(2):409-417. PMID: 33432528. https:// doi.org/10.1007/s12028-020-01179-9</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Веришко А.С., Гирдюк В.П., Лыщик В.Т. Церебральная оксиметрия и ультрасонография в неинвазивном контроле мозгового кровотока у нейрореанимационных пациентов. Сборник материалов конференции студентов и молодых ученых, посвященный 60-летию учреждения образования «Гродненский государственный медицинский университет». 2018:110-111.</mixed-citation><mixed-citation xml:lang="en">Verishko AS, Girdjuk VP, Lyshhik VT. Cerebral’naja oksimetrija i ul’trasonografija v neinvazivnom kontrole mozgovogo krovotoka u nejroreanimacionnyh pacientov. Sbornik materialov konferencii studentov i molodyh uchenyh, posvjashhennyj 60-letiju uchrezhdenija obrazovanija Grodnenskij gosudarstvennyj medicinskij universitet 2018:110-111. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.А., Александров А.Е., Шарков С.М., Басаргина Е.Н., Сугак А.Б., Иванов А.П. Влияние нарушений функциональных параметров сердечно-сосудистой системы на оксигенацию головного мозга у детей. Анестезиология и реаниматология. 2014;59(5):45-47.</mixed-citation><mixed-citation xml:lang="en">Alekseeva EA, Aleksandrov AE, Sharkov SM, Basargina EN, Sugak AB, Ivanov AP. Effect of cardiovascular disorders on cerebral oxygenation in children. Russian Journal of Anaesthesiology and Reanimatology. 2014;59(5):45-47. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fischer GW, Lin HM, Krol M, et al. Noninvasive cerebral oxygenation may predict outcome in patients undergoing aortic arch surgery. J Thorac Cardiovasc Surg. 2011;141(3):815-821. PMID: 20579669. https://doi.org/10.1016/j.jtcvs.2010.05.017</mixed-citation><mixed-citation xml:lang="en">Fischer GW, Lin HM, Krol M, et al. Noninvasive cerebral oxygenation may predict outcome in patients undergoing aortic arch surgery. J Thorac Cardiovasc Surg. 2011;141(3):815-821. PMID: 20579669. https://doi.org/10.1016/j.jtcvs.2010.05.017</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Massaro AN, Govindan RB, Vezina G, et al. Impaired cerebral autoregulation and brain injury in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. J Neurophysiol. 2015;114(2):818-824. PMID: 26063779. PMCID: PMC4533061. https://doi.org/10.1152/jn.00353.2015</mixed-citation><mixed-citation xml:lang="en">Massaro AN, Govindan RB, Vezina G, et al. Impaired cerebral autoregulation and brain injury in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. J Neurophysiol. 2015;114(2):818-824. PMID: 26063779. PMCID: PMC4533061. https://doi.org/10.1152/jn.00353.2015</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Peng S, Boudes E, Tan X, Saint-Martin C, Shevell M, Wintermark P. Does near-infrared spectroscopy identify asphyxiated newborns at risk of developing brain injury during hypothermia treatment?. Am J Perinatol. 2015;32(6):555-564. PMID: 25594221. https://doi.org/10.1055/s-0034-1396692</mixed-citation><mixed-citation xml:lang="en">Peng S, Boudes E, Tan X, Saint-Martin C, Shevell M, Wintermark P. Does near-infrared spectroscopy identify asphyxiated newborns at risk of developing brain injury during hypothermia treatment?. Am J Perinatol. 2015;32(6):555-564. PMID: 25594221. https://doi.org/10.1055/s-0034-1396692</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Peng C, Hou X. Applications of functional near-infrared spectroscopy (fNIRS) in neonates. Neurosci Res. 2021;170:18-23. PMID: 33347910. https://doi.org/10.1016/j.neures.2020.11.003</mixed-citation><mixed-citation xml:lang="en">Peng C, Hou X. Applications of functional near-infrared spectroscopy (fNIRS) in neonates. Neurosci Res. 2021;170:18-23. PMID: 33347910. https://doi.org/10.1016/j.neures.2020.11.003</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Гнедько Т.В., Капура Н.Г., Санковец Д.Н., Улезко Е.А., Берестень С.А. Показатели церебральной оксигенации и гемодинамики у новорожденных с респираторными расстройствами. Педиатрия. Восточная Европа. 2016;4(3):381-388.</mixed-citation><mixed-citation xml:lang="en">Gnedko T, Kapura N, Sankovets D, Ulezko E, Beresten S. Indicators of cerebral oxygenation and hemodynamics in neonates with respiratory disorders. Pediatrics. Eastern Europe. 2016; 4(3):381- 388. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Санковец Д.Н., Гнедько Т.В., Свирская О.Я. Амплитуда суточных колебаний церебральной оксигенации как критерий эффективности интенсивной терапии у новорожденныхс респираторными расстройствами. Педиатрия. Восточная Европа. 2020;8(4):498-512. https://doi.org/10.34883/pi.2020.8.4.002</mixed-citation><mixed-citation xml:lang="en">Sankovets D, Hnedzko T, Svirskaya O. Daily Amplitude of Cerebral Regional Oxygen Saturationas a Criterion of Eff ectiveness of Intensive Care in Neonates with Respiratory Disorders. Pediatrics. Eastern Europe. 2020;8(4):498-512. (In Russ.). https://doi.org/10.34883/pi.2020.8.4.002</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Санковец Д.Н. Применение церебральной оксиметрии в неонатологии. Педиатрия. Восточная Европа. 2015; 4(12):108-117.</mixed-citation><mixed-citation xml:lang="en">Sankovets D.N. Cerebral oximetry: applications in neonatology. Pediatrics. Eastern europe. 2015;4(12):108-117. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Евсюкова И.И., Зверева Н.А., Гурьева Н.Г., Величко Т.А. Изменение оксигенации мозга в цикле сна у здоровых доношенных новорожденных детей. Педиатр. 2019;10(6):5- 11. https://doi.org/10.17816/ped1065-11</mixed-citation><mixed-citation xml:lang="en">Evsyukova II, Zvereva NA, Gurieva NG, Velichko TA. The feature of brain oxygenation in the sleep cycle of healthy newborn babies. Pediatrician. 2019;10(6):5-11. (In Russ.). https://doi.org/10.17816/ped1065-11</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Попова Н.Н. Антенатальные предикторы исходов беременности [автореф. дис. канд. мед. наук]. Ростов-на-Дону. 2010:25.</mixed-citation><mixed-citation xml:lang="en">Popova NN. Antenatalnye prediktory ishodov beremennosti [Cand Med Sci dissertation abstract]. Rostov-on-Don. 2010: 25. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Abramo T, Aggarwal N, Kane I, Crossman K, Meredith M. Cerebral oximetry and cerebral blood flow monitoring in 2 pediatric survivors with out-of-hospital cardiac arrest. Am J Emerg Med. 2014;32(4):394.e5-394.e10. PMID: 24275043. https://doi.org/10.1016/j.ajem.2013.10.039</mixed-citation><mixed-citation xml:lang="en">Abramo T, Aggarwal N, Kane I, Crossman K, Meredith M. Cerebral oximetry and cerebral blood flow monitoring in 2 pediatric survivors with out-of-hospital cardiac arrest. Am J Emerg Med. 2014;32(4):394.e5-394.e10. PMID: 24275043. https://doi.org/10.1016/j.ajem.2013.10.039</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">DiNardo JA. Cerebral Oximetry in Children: So NIRS Yet So Far. Anesth Analg. 2019;128(4):605-606. PMID: 30883409. https://doi.org/10.1213/ane.0000000000002844</mixed-citation><mixed-citation xml:lang="en">Chakravarti S, Srivastava S, Mittnacht AJ. Near infrared spectroscopy (NIRS) in children. Semin Cardiothorac Vasc Anesth. 2008;12(1):70-79. PMID: 18387980. https://doi.org/10.1177/1089253208316444</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Tuna AT, Akkoyun I, Darcin S, Palabiyik O. Effects of carbon dioxide insufflation on regional cerebral oxygenation during laparoscopic surgery in children: a prospective study. Braz J Anesthesiol. 2016;66(3):249-253. PMID: 27108820. https://doi.org/10.1016/j.bjane.2014.10.004</mixed-citation><mixed-citation xml:lang="en">DiNardo JA. Cerebral Oximetry in Children: So NIRS Yet So Far. Anesth Analg. 2019;128(4):605-606. PMID: 30883409. https://doi.org/10.1213/ane.0000000000002844</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Gipson CL, Johnson GA, Fisher R, et al. Changes in cerebral oximetry during peritoneal insufflation for laparoscopic procedures. J Minim Access Surg. 2006;2(2):67-72. PMID: 21170237. PMCID: PMC2997275. https://doi.org/10.4103/0972-9941.26651</mixed-citation><mixed-citation xml:lang="en">Tuna AT, Akkoyun I, Darcin S, Palabiyik O. Effects of carbon dioxide insufflation on regional cerebral oxygenation during laparoscopic surgery in children: a prospective study. Braz J Anesthesiol. 2016;66(3):249-253. PMID: 27108820. https://doi.org/10.1016/j.bjane.2014.10.004</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Hirsch JC, Charpie JR, Ohye RG, Gurney JG. Near-infrared spectroscopy: what we know and what we need to know--a systematic review of the congenital heart disease literature. J Thorac Cardiovasc Surg. 2009;137(1): 154-159.e12. PMID: 19154918. https://doi.org/10.1016/j.jtcvs.2008.08.005</mixed-citation><mixed-citation xml:lang="en">Gipson CL, Johnson GA, Fisher R, et al. Changes in cerebral oximetry during peritoneal insufflation for laparoscopic procedures. J Minim Access Surg. 2006;2(2):67-72. PMID: 21170237. PMCID: PMC2997275. https://doi.org/10.4103/0972-9941.26651</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mitsuta H, Ohdan H, Fudaba Y, et al. Near-infrared spectroscopic analysis of hemodynamics and mitochondrial redox in right lobe grafts in living-donor liver transplantation. Am J Transplant. 2006;6(4):797-805. PMID: 16539638. https://doi.org/10.1111/j.1600-6143.2006.01247.x</mixed-citation><mixed-citation xml:lang="en">Hirsch JC, Charpie JR, Ohye RG, Gurney JG. Near-infrared spectroscopy: what we know and what we need to know--a systematic review of the congenital heart disease literature. J Thorac Cardiovasc Surg. 2009;137(1): 154-159.e12. PMID: 19154918. https://doi.org/10.1016/j.jtcvs.2008.08.005</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Dewhirst E, Walia H, Samora WP, Beebe AC, Klamar JE, Tobias JD. Changes in cerebral oxygenation based on intraoperative ventilation strategy. Med Devices (Auckl). 2018;11:253-258. PMID: 30100768. PMCID: PMC6065577. https://doi.org/10.2147/mder.s158262</mixed-citation><mixed-citation xml:lang="en">Mitsuta H, Ohdan H, Fudaba Y, et al. Near-infrared spectroscopic analysis of hemodynamics and mitochondrial redox in right lobe grafts in living-donor liver transplantation. Am J Transplant. 2006;6(4):797-805. PMID: 16539638. https://doi.org/10.1111/j.1600-6143.2006.01247.x</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Suemori T, Skowno J, Horton S, Bottrell S, Butt W, Davidson AJ. Cerebral oxygen saturation and tissue hemoglobin concentration as predictive markers of early postoperative outcomes after pediatric cardiac surgery. Paediatr Anaesth. 2016;26(2):182-189. PMID: 26619804. https://doi.org/10.1111/pan.12800</mixed-citation><mixed-citation xml:lang="en">Dewhirst E, Walia H, Samora WP, Beebe AC, Klamar JE, Tobias JD. Changes in cerebral oxygenation based on intraoperative ventilation strategy. Med Devices (Auckl). 2018;11:253-258. PMID: 30100768. PMCID: PMC6065577. https://doi.org/10.2147/ mder.s158262</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Greisen G, Leung T, Wolf M. Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care?. Philos Trans A Math Phys Eng Sci. 2011;369(1955):4440-4451. PMID: 22006900. PMCID: PMC3263787. https://doi.org/10.1098/rsta.2011.0261</mixed-citation><mixed-citation xml:lang="en">Suemori T, Skowno J, Horton S, Bottrell S, Butt W, Davidson AJ. Cerebral oxygen saturation and tissue hemoglobin concentration as predictive markers of early postoperative outcomes after pediatric cardiac surgery. Paediatr Anaesth. 2016;26(2):182-189. PMID: 26619804. https://doi.org/10.1111/pan.12800</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Juliana N, Abu Yazit NA, Kadiman S, et al. Intraoperative cerebral oximetry in open heart surgeries reduced postoperative complications: A retrospective study. PLoS One. 2021;16(5):e0251157. PMID: 34038405. PMCID: PMC8153416. https://doi.org/10.1371/journal.pone.0251157</mixed-citation><mixed-citation xml:lang="en">Greisen G, Leung T, Wolf M. Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care?. Philos Trans A Math Phys Eng Sci. 2011;369(1955):4440-4451. PMID: 22006900. PMCID: PMC3263787. https://doi.org/10.1098/rsta.2011.0261</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Knirsch W, Stutz K, Kretschmar O, et al. Regional cerebral oxygenation by NIRS does not correlate with central or jugular venous oxygen saturation during interventional catheterisation in children. Acta Anaesthesiol Scand. 2008;52(10):1370-1374. PMID: 19025530. https://doi.org/10.1111/j.1399-6576.2008.01703.x</mixed-citation><mixed-citation xml:lang="en">Juliana N, Abu Yazit NA, Kadiman S, et al. Intraoperative cerebral oximetry in open heart surgeries reduced postoperative complications: A retrospective study. PLoS One. 2021;16(5):e0251157. PMID: 34038405. PMCID: PMC8153416. https://doi.org/10.1371/journal.pone.0251157</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sakamoto T, Hatsuoka S, Stock UA, et al. Prediction of safe duration of hypothermic circulatory arrest by near-infrared spectroscopy. J Thorac Cardiovasc Surg. 2001;122(2):339-350. PMID: 11479508. https://doi.org/10.1067/mtc.2001.115242</mixed-citation><mixed-citation xml:lang="en">Knirsch W, Stutz K, Kretschmar O, et al. Regional cerebral oxygenation by NIRS does not correlate with central or jugular venous oxygen saturation during interventional catheterisation in children. Acta Anaesthesiol Scand. 2008;52(10):1370-1374. PMID:</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Lian C, Li P, Wang N, Lu Y, Shangguan W. Comparison of basic regional cerebral oxygen saturation values in patients of different ages: a pilot study. J Int Med Res. 2020;48(8):300060520936868. PMID: 32833525. PMCID: PMC7448148. https://doi.org/10.1177/0300060520936868</mixed-citation><mixed-citation xml:lang="en">https://doi.org/10.1111/j.1399-6576.2008.01703.x</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Kandachar SS, Annamalai A. NIRS: So near yet so far (From the brain). Ann Card Anaesth. 2020;23(4):505-507. PMID: 33109813. PMCID: PMC7879887. https://doi.org/10.4103/aca.aca_97_19</mixed-citation><mixed-citation xml:lang="en">Sakamoto T, Hatsuoka S, Stock UA, et al. Prediction of safe duration of hypothermic circulatory arrest by near-infrared spectroscopy. J Thorac Cardiovasc Surg. 2001;122(2):339-350. PMID: 11479508. https://doi.org/10.1067/mtc.2001.115242</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Korček P, Straňák Z, Širc J, Naulaers G. The role of nearinfrared spectroscopy monitoring in preterm infants. J Perinatol. 2017;37(10):1070-1077. PMID: 28471443. https://doi.org/10.1038/jp.2017.60</mixed-citation><mixed-citation xml:lang="en">Lian C, Li P, Wang N, Lu Y, Shangguan W. Comparison of basic regional cerebral oxygen saturation values in patients of different ages: a pilot study. J Int Med Res. 2020;48(8):300060520936868. PMID: 32833525. PMCID: PMC7448148. https://doi.org/10.1177/0300060520936868</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Kussman BD, Wypij D, DiNardo JA, et al. Cerebral oximetry during infant cardiac surgery: evaluation and relationship to early postoperative outcome. Anesth Analg. 2009;108(4):1122- 1131. PMID: 19299774. PMCID: PMC2782610. https://doi.org/10.1213/ane.0b013e318199dcd2</mixed-citation><mixed-citation xml:lang="en">Kandachar SS, Annamalai A. NIRS: So near yet so far (From the brain). Ann Card Anaesth. 2020;23(4):505-507. PMID: 33109813. PMCID: PMC7879887. https://doi.org/10.4103/aca.aca_97_19</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Sakamoto T, Zurakowski D, Duebener LF, et al. Interaction of temperature with hematocrit level and pH determines safe duration of hypothermic circulatory arrest. J Thorac Cardiovasc Surg. 2004;128(2):220-232. PMID: 15282458. https://doi.org/10.1016/j.jtcvs.2003.11.070</mixed-citation><mixed-citation xml:lang="en">Korček P, Straňák Z, Širc J, Naulaers G. The role of nearinfrared spectroscopy monitoring in preterm infants. J Perinatol. 2017;37(10):1070-1077. PMID: 28471443. https://doi.org/10.1038/jp.2017.60</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Zogogiannis ID, Iatrou CA, Lazarides MK, et al. Evaluation of an intraoperative algorithm based on near-infrared refracted spectroscopy monitoring, in the intraoperative decision for shunt placement, in patients undergoing carotid endarterectomy. Middle East J Anaesthesiol. 2011;21(3):367-373. PMID: 22428491</mixed-citation><mixed-citation xml:lang="en">Kussman BD, Wypij D, DiNardo JA, et al. Cerebral oximetry during infant cardiac surgery: evaluation and relationship to early postoperative outcome. Anesth Analg. 2009;108(4):1122- 1131. PMID: 19299774. PMCID: PMC2782610. https://doi.org/10.1213/ane.0b013e318199dcd2</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Lecluyse V, Couture EJ, Denault AY. A Proposed Approach to Cerebral and Somatic Desaturation in the Intensive Care Unit: Preliminary Experience and Review. J Cardiothorac Vasc Anesth. 2017;31(5):1805-1809. PMID: 28552296. https://doi.org/10.1053/j.jvca.2017.02.175</mixed-citation><mixed-citation xml:lang="en">Sakamoto T, Zurakowski D, Duebener LF, et al. Interaction of temperature with hematocrit level and pH determines safe duration of hypothermic circulatory arrest. J Thorac Cardiovasc Surg. 2004;128(2):220-232. PMID: 15282458. https://doi.org/10.1016/j.jtcvs.2003.11.070</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Kussman BD, Wypij D, Laussen PC, et al. Relationship of intraoperative cerebral oxygen saturation to neurodevelopmental outcome and brain magnetic resonance imaging at 1 year of age in infants undergoing biventricular repair. Circulation. 2010;122(3):245-254. PMID: 20606124. PMCID: PMC2945235. https://doi.org/10.1161/circulationaha.109.902338</mixed-citation><mixed-citation xml:lang="en">Zogogiannis ID, Iatrou CA, Lazarides MK, et al. Evaluation of an intraoperative algorithm based on near-infrared refracted spectroscopy monitoring, in the intraoperative decision for shunt placement, in patients undergoing carotid endarterectomy. Middle East J Anaesthesiol. 2011;21(3):367-373. PMID: 22428491</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Vretzakis G, Georgopoulou S, Stamoulis K, et al. Monitoring of brain oxygen saturation (INVOS) in a protocol to direct blood transfusions during cardiac surgery: a prospective randomized clinical trial. J Cardiothorac Surg. 2013;8:145. PMID: 23758929. PMCID: PMC3691733. https://doi.org/10.1186/1749-8090-8-145</mixed-citation><mixed-citation xml:lang="en">Lecluyse V, Couture EJ, Denault AY. A Proposed Approach to Cerebral and Somatic Desaturation in the Intensive Care Unit: Preliminary Experience and Review. J Cardiothorac Vasc Anesth. 2017;31(5):1805-1809. PMID: 28552296. https://doi.org/10.1053/j.jvca.2017.02.175</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Holmgaard F, Vedel AG, Rasmussen LS, Paulson OB, Nilsson JC, Ravn HB. The association between postoperative cognitive dysfunction and cerebral oximetry during cardiac surgery: a secondary analysis of a randomised trial. Br J Anaesth. 2019;123(2):196-205. PMID: 31104758. PMCID: PMC6676044. https://doi.org/10.1016/j.bja.2019.03.045</mixed-citation><mixed-citation xml:lang="en">Kussman BD, Wypij D, Laussen PC, et al. Relationship of intraoperative cerebral oxygen saturation to neurodevelopmental outcome and brain magnetic resonance imaging at 1 year of age in infants undergoing biventricular repair. Circulation. 2010;122(3):245-254. PMID: 20606124. PMCID: PMC2945235. https://doi.org/10.1161/circulationaha.109.902338</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Vretzakis G, Georgopoulou S, Stamoulis K, et al. Monitoring of brain oxygen saturation (INVOS) in a protocol to direct blood transfusions during cardiac surgery: a prospective randomized clinical trial. J Cardiothorac Surg. 2013;8:145. PMID: 23758929. PMCID: PMC3691733. https://doi.org/10.1186/1749-8090-8-145</mixed-citation><mixed-citation xml:lang="en">Vretzakis G, Georgopoulou S, Stamoulis K, et al. Monitoring of brain oxygen saturation (INVOS) in a protocol to direct blood transfusions during cardiac surgery: a prospective randomized clinical trial. J Cardiothorac Surg. 2013;8:145. PMID: 23758929. PMCID: PMC3691733. https://doi.org/10.1186/1749-8090-8-145</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Holmgaard F, Vedel AG, Rasmussen LS, Paulson OB, Nilsson JC, Ravn HB. The association between postoperative cognitive dysfunction and cerebral oximetry during cardiac surgery: a secondary analysis of a randomised trial. Br J Anaesth. 2019;123(2):196-205. PMID: 31104758. PMCID: PMC6676044. https://doi.org/10.1016/j.bja.2019.03.045</mixed-citation><mixed-citation xml:lang="en">Holmgaard F, Vedel AG, Rasmussen LS, Paulson OB, Nilsson JC, Ravn HB. The association between postoperative cognitive dysfunction and cerebral oximetry during cardiac surgery: a secondary analysis of a randomised trial. Br J Anaesth. 2019;123(2):196-205. PMID: 31104758. PMCID: PMC6676044. https://doi.org/10.1016/j.bja.2019.03.045</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
