inovmedИнновационная медицина КубаниInnovative Medicine of Kuban2541-9897Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 110.35401/2541-9897-2026-11-1-123-131inovmed-1450Research ArticleОБЗОРЫREVIEWSПрименение материалов на основе шёлка паутины в регенеративной медицине: от исследований in vivo к клиническому применениюApplication of Spider Silk-Based Materials in Regenerative Medicine: From In Vivo Studies to Clinical Usehttps://orcid.org/0009-0003-2986-5251ЗамановаР. А.ZamanovaR. A.

Заманова Розалия Артуровна - младший научный сотрудник лаборатории биопринтинга Института фундаментальной медицины.

450008, Уфа, ул. Ленина, 3

Rozalia A. Zamanova - Junior Researcher, Bioprinting Laboratory, Institute of Fundamental Medicine, Bashkir State Medical University.

3 Lenina St., Ufa, 450008

rozzama@yandex.ruhttps://orcid.org/0000-0002-4317-8146ПятницкаяС. В.PiatnitskaiaS. V.

Пятницкая Светлана Викторовна - к. м. н, доцент кафедры внутренних болезней, заведующий лабораторией биопринтинга Института фундаментальной медицины.

Уфа

Svetlana V. Piatnitskaia - Cand. Sci. (Med.), Associate Professor, Department of Internal Medicine, Head of the Bioprinting Laboratory, Institute of Fundamental Medicine, Bashkir State Medical University.

Ufa

https://orcid.org/0009-0006-3082-941XФайрушинаА. И.FairushinaA. I.

Файрушина Аделия Ильдаровна - младший научный сотрудник лаборатории биопринтинга Института фундаментальной медицины.

Уфа

Adelia I. Fairushina - Junior Researche, the Bioprinting Laboratory, Institute of Fundamental Medicine, Bashkir State Medical University.

Ufa

https://orcid.org/0000-0002-0100-6100СафинШ. М.SafinSh. M.

Сафин Шамиль Махмутович - д. м. н., доцент, заведующий кафедрой нейрохирургии и медицинской реабилитации с курсом ИДПО.

Уфа

Shamil M. Safin - Dr. Sci. (Med.), Associate Professor, Head of the Department of Neurosurgery with the Course of Medical Rehabilitation of the Institute of Additional Professional Training, Bashkir State Medical University.

Ufa

https://orcid.org/0000-0003-4096-1087СмирновВ. А.SmirnovV. A.

Смирнов Владимир Александрович - старший научный сотрудник Отдела неотложной нейрохирургии.

Москва

Vladimir A. Smirnov - Senior Researcher, Department of Emergency Neurosurgery, N.V. Sklifosovsky Research Institute for Emergency Medicine.

Moscow

https://orcid.org/0000-0002-9413-3167Лебенштейн-ГумовскиМ. В.Lebenstein-GumovskiM. V.

Лебенштейн-Гумовски Михаил Владимирович - к. м. н., старший научный сотрудник, врач-нейрохирург Отдела неотложной нейрохирургии, НИИ скорой помощи им. Н.В. Склифосовского; доцент кафедры нейрохирургии и медицинской реабилитации с курсом ИДПО, БГМУ.

Москва; Уфа

Mikhail V. Lebenstein-Gumovski - Cand. Sci. (Med.), Senior Researcher, Neurosurgeon, Department of Emergency Neurosurgery, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor, Department of Neurosurgery with the Course of Medical Rehabilitation of the Institute of Additional Professional Training, Bashkir State Medical University.

Moscow; Ufa

https://orcid.org/0000-0002-1473-9901ГригорьевскийЕ. Д.GrigorevskiyE. D.

Григорьевский Евгений Дмитриевич - врач-нейрохирург, 2-е нейрохирургическое отделение.

Москва

Evgeny D. Grigorevskiy - Neurosurgeon, 2-nd Neurosurgery Department, Russian Center of Neurology and Neurosciences.

Moscow

https://orcid.org/0000-0003-3515-8329ГриньА. А.GrinA. A.

Гринь Андрей Анатольевич - д. м. н., профессор, член-корреспондент РАН, руководитель Отдела неотложной нейрохирургии.

Москва

Andrey A. Grin - Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Emergency Neurosurgery, N.V. Sklifosovsky Research Institute for Emergency Medicine.

Moscow

https://orcid.org/0000-0001-5256-0905КрыловВ. В.KrylovV. V.

Крылов Владимир Викторович - д. м. н., профессор, академик РАН, заведующий кафедрой фундаментальной нейрохирургии, РНИМУ им. Н.И. Пирогова; главный научный сотрудник отдела неотложной нейрохирургии, НИИ скорой помощи им. Н.В. Склифосовского; директор института функциональной нейрохирургии, РЦНН.

Москва

Vladimir V. Krylov - Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Department of Fundamental Neurosurgery, Pirogov Russian National Research Medical University; Chief Researcher, Department of Emergency Neurosurgery, N.V. Sklifosovsky Research Institute for Emergency Medicine; Head of the Institute of Functional Neurosurgery, Russian Center of Neurology and Neurosciences.

Moscow

https://orcid.org/0000-0003-2125-4897ПавловВ. Н.PavlovV. N.

Павлов Валентин Николаевич - д. м. н., профессор, академик РАН, заведующий кафедрой урологии и онкологии.

Уфа

Valentin N. Pavlov - Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Department of Urology and Oncology, Bashkir State Medical University.

Ufa

Башкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationНаучно-исследовательский институт скорой помощи им. Н.В. СклифосовскогоРоссияN.V. Sklifosovsky Research Institute for Emergency MedicineRussian FederationБашкирский государственный медицинский университет; Научно-исследовательский институт скорой помощи им. Н.В. СклифосовскогоРоссияBashkir State Medical University; N.V. Sklifosovsky Research Institute for Emergency MedicineRussian FederationРоссийский центр неврологии и нейронаукРоссияRussian Сenter of Neurology and NeurosciencesRussian FederationНаучно-исследовательский институт скорой помощи им. Н.В. Склифосовского; Российский центр неврологии и нейронаук; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Сenter of Neurology and Neurosciences; Pirogov Russian National Research Medical UniversityRussian Federation202630032026111123131Copyright © Заманова Р.А., Пятницкая С.В., Файрушина А.И., Сафин Ш.М., Смирнов В.А., Лебенштейн-Гумовски М.В., Григорьевский Е.Д., Гринь А.А., Крылов В.В., Павлов В.Н., 20262026Заманова Р.А., Пятницкая С.В., Файрушина А.И., Сафин Ш.М., Смирнов В.А., Лебенштейн-Гумовски М.В., Григорьевский Е.Д., Гринь А.А., Крылов В.В., Павлов В.Н.Zamanova R.A., Piatnitskaia S.V., Fairushina A.I., Safin S.M., Smirnov V.A., Lebenstein-Gumovski M.V., Grigorevskiy E.D., Grin A.A., Krylov V.V., Pavlov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.innovmedkub.ru/jour/article/view/1450

В данном обзоре рассмотрено применение материалов на основе шёлка паутины в регенеративной медицине. Шёлк паутины обладает уникальным сочетанием механических и биологических характеристик, что делает его перспективным биоматериалом для тканевой инженерии. Проведен анализ in vivo-исследований на животных моделях и первых клинических испытаний, демонстрирующих способность шёлка направлять рост клеток, ускорять заживление ран и способствовать регенерации периферических нервов. Обсуждаются перспективы масштабного производства паучьего шёлка и его применения в медицине.

This review examines the use of spider-silk-based materials in regenerative medicine. Spider silk possesses a unique combination of mechanical and biological properties, making it a promising biomaterial for tissue engineering. An analysis of in vivo studies in animal models and the first clinical trials is presented, demonstrating the ability of spider silk to direct cell growth, accelerate wound healing, and promote peripheral nerve regeneration. The prospects for large-scale production of spider silk and its medical applications are discussed.

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The authors declare that there are no conflicts of interest present.