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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2541-9897-2026-11-2-46-55</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-1525</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Оценка клинической эффективности использования крови и её компонентов при лечении ожоговой анемии</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the Clinical Efficacy of Blood and Blood Component Use in the Treatment of Burn-Related Anemia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2238-9067</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хакимов</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khakimov</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хакимов Эркин Абдухалилович - д. м. н., доцент, заведующий отделением комбустиологии.</p><p>Самарканд, Самаркандский район, мсг Узбеккенти</p></bio><bio xml:lang="en"><p>Erkin A. Khakimov - Dr. Sci. (Med.), Associate Professor, Head of the Department of Combustiology.</p><p>I.g.c. Uzbekkenti, Samarkand, Samarkand district</p></bio><email xlink:type="simple">erkinxakimov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-8387-5026</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хайитов</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Khayitov</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хайитов Лазиз Милионерович - к. м. н., ассистент кафедры хирургии и трансплантологии.</p><p>Самарканд</p></bio><bio xml:lang="en"><p>Laziz M. Khayitov - Cand. Sci. (Med.), Assistant Professor, Department of Surgery and Transplantology.</p><p>Samarkand</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-7989-8127</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зувайтов</surname><given-names>Ш. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Zuvaytov</surname><given-names>Sh. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зувайтов Шохрух Гайрат угли - свободный соискатель кафедры хирургии, эндоскопии, реанимации-анестезиологии факультета ПДО.</p><p>Самарканд</p></bio><bio xml:lang="en"><p>Shokhrukh G. Zuvaytov - Independent Researcher, Department of Surgery, Endoscopy, and Anesthesiology and Intensive Care, Faculty of Postgraduate Education.</p><p>Samarkand</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-1211-7197</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ярматов</surname><given-names>К. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Yarmatov</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ярматов Комил Эркинович - свободный соискатель реаниматолог-анестезиолог.</p><p>Ташкент</p></bio><bio xml:lang="en"><p>Komil E. Yarmatov - Independent Researcher, Anesthesiologist– Intensivist.</p><p>Tashkent</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-8213-897X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аброров</surname><given-names>Ш. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Abrorov</surname><given-names>Sh. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аброров Шахбозжон Нематзода - свободный соискатель кафедры хирургических болезней № 2.</p><p>Самарканд</p></bio><bio xml:lang="en"><p>Shakhbozjon N. Abrorov - Independent Researcher, Department of Surgical Diseases No. 2.</p><p>Samarkand</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-0782-3548</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таджиев</surname><given-names>З. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Tadzhiev</surname><given-names>Z. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Таджиев Зохид Юсупович – комбустиолог.</p><p>Самарканд</p></bio><bio xml:lang="en"><p>Zokhid Yu. Tadzhiev - Burn Specialist.</p><p>Samarkand</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-1226-0995</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдихалилов</surname><given-names>М. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdikhalilov</surname><given-names>M. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абдихалилов Мирзиё Эркинович - клинический ординатор.</p><p>Самарканд</p></bio><bio xml:lang="en"><p>Mirziyo E. Abdikhalilov – Resident.</p><p>Samarkand</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-8450-874X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Некбаев</surname><given-names>Х. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Nekbayev</surname><given-names>H. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Некбаев Хасан Сайфуллоевич - врач-ординатор отделения комбустиологии.</p><p>Самарканд</p></bio><bio xml:lang="en"><p>Hasan S. Nekbayev - Resident, Department of Combustiology.</p><p>Samarkand</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Самаркандский филиал Республиканского научного центра экстренной медицинской помощи</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Samarkand Branch of Republican Research Centre of Emergency Medicine</institution><country>Uzbekistan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Самаркандский государственный медицинский университет</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Samarkand State Medical University</institution><country>Uzbekistan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Республиканский научный центр экстренной медицинской помощи</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Republican Research Centre of Emergency Medicine</institution><country>Uzbekistan</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Самаркандский филиал Республиканского научного центра экстренной медицинской помощи</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samarkand State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>22</day><month>05</month><year>2026</year></pub-date><volume>11</volume><issue>2</issue><fpage>46</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хакимов Э.А., Хайитов Л.М., Зувайтов Ш.Г., Ярматов К.Э., Аброров Ш.Н., Таджиев З.Ю., Абдихалилов М.Э., Некбаев Х.С., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Хакимов Э.А., Хайитов Л.М., Зувайтов Ш.Г., Ярматов К.Э., Аброров Ш.Н., Таджиев З.Ю., Абдихалилов М.Э., Некбаев Х.С.</copyright-holder><copyright-holder xml:lang="en">Khakimov E.A., Khayitov L.M., Zuvaytov S.G., Yarmatov K.E., Abrorov S.N., Tadzhiev Z.Y., Abdikhalilov M.E., Nekbayev H.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/1525">https://www.innovmedkub.ru/jour/article/view/1525</self-uri><abstract><sec><title>Цель</title><p>Цель: Анализ эффективности и целесообразности использования крови и её компонентов при лечении анемии у пациентов с ожоговой болезнью.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: В отделении комбустиологии Самаркандского филиала Республиканского научного центра экстренной медицинской помощи в 2020–2025 гг. изучены результаты лечения 920 пациентов с тяжёлыми ожоговыми травмами. Больные были разделены на две группы.</p><p>В основную группу вошли 570 (61,9%) пациентов с тяжёлыми и крайне тяжёлыми ожогами. Лечение ожоговой анемии проводили с учётом её этиопатогенеза. Оно включало индивидуализированную инфузионно-трансфузионную терапию, минимизацию кровопотери из раны, а также плазмотрансфузию, гемотрансфузию и переливание 5, 10 и 20%-х растворов альбумина по клинико-лабораторным показаниям.</p><p>В контрольную группу включили 350 (38,04 %) пациентов с тяжёлыми и крайне тяжёлыми ожогами. Им проводили инфузионно-трансфузионную терапию по традиционной схеме. Возраст пациентов варьировал от 6 месяцев до 76 лет.</p></sec><sec><title>Результаты</title><p>Результаты: Своевременное лечение ожоговой анемии, как тяжёлого осложнения, основывалось на клинической картине заболевания и лабораторных показателях крови. Индивидуальный подход к трансфузионной терапии включал: раннее проведение плазмотрансфузии, гемотрансфузии или трансфузии альбумина; использование гемостатических губок при обработке ожоговых ран; минимизацию кровопотери во время хирургических вмешательств; своевременное назначение рекомбинантного эритропоэтина в комбинации с препаратами железа; применение антигипоксантов и антиоксидантов в ранние сроки для предупреждения гемолиза эритроцитов.</p><p>Реализация данного комплексного подхода способствовала снижению частоты осложнений ожоговой анемии. В основной группе они наблюдались у 188 из 570 пациентов (32,98%). В то же время в контрольной группе ранние и поздние осложнения были отмечены у всех 350 пациентов (100%).</p><p>Индивидуализированный подход к гемотрансфузии не только уменьшил частоту осложнений, но и оказал значительное влияние на снижение показателей летальности.</p></sec><sec><title>Заключение</title><p>Заключение: Таким образом, при лечении анемии, развивающейся при ожоговой болезни, индивидуализированный подход, основанный на клинических и лабораторных данных, позволил существенно улучшить результаты лечения. Он включал проведение гемотрансфузии, плазмотрансфузии, трансфузии альбумина, а также минимизацию кровопотери.</p><p>По данным исследований за последние 5 лет, у 570 пациентов основной группы профилактика анемии начиналась с первого дня госпитализации. В результате частота тяжёлых осложнений (сепсис, полиорганная недостаточность, миокардит, ДВСсиндром, вторичное углубление раны, «ожоговое истощение») снизилась со 100 до 32,98%. Кроме того, отмечено значительное снижение показателей летальности от ожоговой болезни.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: To analyze the efficacy and appropriateness of using blood and its components in the treatment of anemia in patients with burn disease.</p></sec><sec><title>Materials and methods</title><p>Materials and methods: In the Department of Combustiology at the Samarkand Branch of the Republican Research Centre of Emergency Medicine, from 2020 to 2025, the treatment outcomes of 920 patients with severe burn injuries were analyzed. The patients were divided into two groups.</p><p>The main group included 570 (61.9%) patients with severe and extremely severe burns. Treatment of burn-related anemia was carried out with consideration of its etiopathogenesis. It included individualized infusion-transfusion therapy, minimization of wound blood loss, as well as plasma transfusions, blood transfusion, and administration of 5%, 10%, and 20% albumin solutions according to clinical and laboratory indicators.</p><p>The control group consisted of 350 (38.04%) patients with severe and extremely severe burns. They received infusion-transfusion therapy according to the standard protocol. The patients’ age ranged from 6 months to 76 years.</p></sec><sec><title>Results</title><p>Results: Timely treatment of burn-related anemia, as a severe complication was based on the clinical course of the disease and laboratory blood parameters. An individualized approach to transfusion therapy included: early administration of plasma transfusions, blood transfusion, or albumin transfusions; use of hemostatic sponges during burn wound management; minimization of blood loss during surgical interventions; timely administration of recombinant erythropoietin in combination with iron preparations; and early use of antihypoxants and antioxidants to prevent erythrocyte hemolysis.</p><p>The implementation of this comprehensive approach contributed to a reduction in the incidence of complications associated with burn-related anemia. In the main group, complications were observed in 188 of 570 patients (32.98%). In contrast, in the control group, early and late complications were observed in all 350 patients (100%).</p><p>An individualized approach to blood transfusion not only reduced the incidence of complications but also had a significant impact on lowering mortality rates.</p></sec><sec><title>Conclusion</title><p>Conclusion: Thus, in the treatment of anemia developing in burn disease, an individualized approach based on clinical and laboratory data significantly improved treatment outcomes. It included blood transfusion, plasma transfusion, albumin transfusion, as well as minimization of blood loss.</p><p>According to studies conducted over the past 5 years, in 570 patients of the main group, prevention of anemia was initiated from the first day of hospitalization. As a result, the incidence of severe complications (sepsis, multiple organ failure, myocarditis, disseminated intravascular coagulation syndrome, secondary wound deepening, and “burn-related exhaustion”) decreased from 100% to 32.98%. In addition, a significant reduction in mortality rates from burn disease was observed.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ожоговая болезнь</kwd><kwd>ожоговая анемия</kwd><kwd>гемотрансфузия</kwd><kwd>плазмотрансфузия</kwd><kwd>трансфузия альбумина</kwd><kwd>аутодермопластика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>burn disease</kwd><kwd>burn-related anemia</kwd><kwd>blood transfusion</kwd><kwd>plasma transfusion</kwd><kwd>albumin transfusion</kwd><kwd>autologous skin grafting</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dobson GP, Morris JL, Letson HL. 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