inovmedИнновационная медицина КубаниInnovative Medicine of Kuban2541-9897Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 110.35401/2541-9897-2026-11-2-93-100inovmed-1534Research ArticleОБЗОРЫREVIEWSКардио-рено-метаболический синдром: обзор патогенеза через призму инсулинорезистетностиCardiovascular-Kidney-Metabolic Syndrome: Review of a Pathogenesis through the Prism of Insulin Resistancehttps://orcid.org/0000-0002-5383-8355АвагимянА. А.AvagimyanA. A.

Авагимян Ашот Арманович, к. м. н., преподаватель кафедры пропедевтики внутренних болезней.

Ул. Корюна 2а, Ереван, 0025

Ashot A. Avagimyan - Cand. Sci. (Med.), Assistant Professor at the Department of Internal Diseases Propaedeutics.

2a Koryun St., Yerevan, 0025

dr.ashotavagimyan@gmail.comhttps://orcid.org/0000-0001-7140-0739ТрофименкоА. И.TrofimenkoA. I.

Трофименко Артем Иванович - к. м. н., доцент, доцент кафедры патологической физиологии.

Краснодар

Artem I. Trofimenko - Cand. Sci. (Med.), Associate Professor, Pathological Physiology Department.

Krasnodar

https://orcid.org/0000-0001-5988-8516ДжндоянЗ. Т.DjndoyanZ. T.

Джндоян Зинаида Титаловна - д. м. н., профессор, заведующий кафедрой пропедевтики внутренних болезней.

Ереван

Zinaida T. Djndoyan - Dr. Sci. (Med.), Professor, Head of Department of Internal Diseases Propaedeutics.

Yerevan

https://orcid.org/0009-0003-6872-0282КарсянС. М.KarsianS. M.

Карсян Сергей Микаелович - студент 3-го курса факультета общей медицины (департамент иностранных студентов).

Ереван

Sergei M. Karsian - 3rd year Student, Faculty of General Medicine.

Yerevan

https://orcid.org/0009-0001-8376-9274СивараманВ.SivaramanV.

Сивараман Вигнесваран - студент 3-го курса факультета общей медицины (департамент иностранных студентов).

Ереван

Vigneswaran Sivaraman - 3rd year Student, Faculty of General Medicine.

Yerevan

https://orcid.org/0000-0002-7349-3462МирзоянЛ. Р.MirzoyanL. R.

Мирзоян Лилия Робертовна - аспирант кафедры общественного здоровья и здравоохранения, Медицинский институт ФГБОУ ВО «ТГУ им. Г.Р. Державина».

Тамбов

Lilia R. Mirzoyan - Postgraduate Student, Department of Public Health and Healthcare.

Tambov

https://orcid.org/0000-0002-1324-6275АгаджановаЕ. М.AghajanovaE. M.

Агаджанова Елена Михайловна - д. м. н., профессор, заведующий кафедрой эндокринологии.

Ереван

Elena M. Aghajanova - Dr. Sci. (Med.), Professor, Head of Endocrinology Department.

Yerevan

https://orcid.org/0000-0002-9457-8879УразоваО. И.UrazovaO. I.

Уразова Ольга Ивановна, д. м. н., профессор, членкорреспондент РАН, заведующий кафедрой патофизиологии.

Томск

Olga I. Urazova - Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Pathophysiology Department.

Tomsk

https://orcid.org/0000-0001-7896-2080КактурскийЛ. В.KakturskiyL. V.

Кактурский Лев Владимирович - д. м. н., профессор, член-корреспондент РАН, научный руководитель НИИМЧ им. акад. А. П. Авцына ФГБУ «РНЦХ им. акад. Б. В. Петровского».

Москва

Lev V. Kakturskiy -- Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Scientific Director of Avtsyn Research Institute of Human Morphology.

Moscow

https://orcid.org/0000-0002-4165-804XПогосоваН. В.PogosovaN. V.

Погосова Нана Вачиковна - д. м. н., профессор, членкорреспондент РАН, заместитель генерального директора по науке и профилактической кардиологии, Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова; заведующий кафедрой доказательной медицины, РУДН им. П. Лумумбы.

Москва

Nana V. Pogosova - Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Deputy General Director for Science and Preventive Cardiology, NMRCC after academician E. Chazov, Head of the Department of Evidence Based Medicine, Patrice Lumumba PFUR.

Moscow

Ереванский государственный медицинский университет им. М. ГерациАрменияYerevan State Medical University after Mkhitar HeratsiArmeniaКубанский государственный медицинский университетРоссияKuban State Medical UniversityRussian FederationТамбовский государственный университетРоссияDerzhavin Tambov State UniversityRussian FederationСибирский государственный медицинский университетРоссияSiberian State Medical UniversityRussian FederationРоссийский научный центр хирургии им. акад. Б.В. ПетровскогоРоссияPetrovsky National Research Centre of SurgeryRussian FederationНаучный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова; Российский университет дружбы народов им. П. ЛумумбыРоссияCentre of Cardiology after academician E. Chazov; Patrice Lumumba Peoples’ Friendship University of RussiaRussian Federation20262205202611293100Copyright © Авагимян А.А., Трофименко А.И., Джндоян З.Т., Карсян С.М., Сивараман В., Мирзоян Л.Р., Агаджанова Е.М., Уразова О.И., Кактурский Л.В., Погосова Н.В., 20262026Авагимян А.А., Трофименко А.И., Джндоян З.Т., Карсян С.М., Сивараман В., Мирзоян Л.Р., Агаджанова Е.М., Уразова О.И., Кактурский Л.В., Погосова Н.В.Avagimyan A.A., Trofimenko A.I., Djndoyan Z.T., Karsian S.M., Sivaraman V., Mirzoyan L.R., Aghajanova E.M., Urazova O.I., Kakturskiy L.V., Pogosova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.innovmedkub.ru/jour/article/view/1534

В статье представлен обзор патогенеза кардио-рено-метаболического синдрома – мультифакторного состояния, при котором сердечно-сосудистые, почечные и метаболические нарушения взаимно отягощают друг друга. Центральным звеном синдрома выступает инсулинорезистентность, приводящая к компенсаторной гиперинсулинемии. Последняя активирует симпатическую нервную систему и ренин-ангиотензин-альдостероновую систему, способствуя задержке натрия, эндотелиальной дисфункции, артериальной гипертензии и атеросклерозу. В почках гипергликемия запускает сигнальные пути PKC и JAK-STAT/NF-κB, а также накопление конечных продуктов гликирования (AGE), что вызывает воспаление, фиброз и прогрессирование диабетической нефропатии.

This article presents a review of the pathogenesis of cardiovascular-kidney-metabolic syndrome – a multifactorial condition in which cardiovascular, renal, and metabolic disorders mutually aggravate each other. Insulin resistance serves as the central link of the syndrome, leading to compensatory hyperinsulinemia. The latter activates the sympathetic nervous system and the renin-angiotensin-aldosterone system, promoting sodium retention, endothelial dysfunction, arterial hypertension, and atherosclerosis. In the kidneys, hyperglycemia triggers PKC and JAK-STAT/NF-κB signaling pathways as well as the accumulation of advanced glycation end products (AGEs), resulting in inflammation, fibrosis, and progression of diabetic nephropathy.

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The authors declare that there are no conflicts of interest present.