inovmedИнновационная медицина КубаниInnovative Medicine of Kuban2541-9897Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 110.35401/2541-9897-2026-11-2-101-108inovmed-1536Research ArticleОБЗОРЫREVIEWSМикробиом при раке предстательной железыMicrobiome in Prostate Cancerhttps://orcid.org/0000-0003-2125-4897ПавловВ. Н.PavlovV. N.

Павлов Валентин Николаевич - д.м.н., профессор, академик РАН, заведующий кафедрой урологии и онкологии.

450077, Уфа, ул. Ленина, 3

Valentin N. Pavlov - Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Urology and Oncology Department.

3 Lenina St., Ufa, 450077

pavlov@bashgmu.ruhttps://orcid.org/0000-0003-3330-9437ГимрановаИ. А.GimranovaI. A.

Гимранова Ирина Анатольевна - к. м. н., доцент, заведующий кафедрой фундаментальной и прикладной микробиологии.

Уфа

Irina A. Gimranova - Cand. Sci. (Med.), Associate Professor, Head of the Department of Fundamental and Applied Microbiology.

Ufa

https://orcid.org/0009-0005-2508-7901ГазизуллинаГ. Р.GazizullinaG. R.

Газизуллина Гульнара Раилевна - заведующий лабораторией микробиома человека.

Уфа

Gulnara R. Gazizullina - Head of the Laboratory of Human Microbiome.

Ufa

https://orcid.org/0000-0003-4292-4562ШвецД. Ю.ShvetsD. Yu.

Швец Дарья Юрьевна - аспирант 4-го года обучения, Институт биохимии и генетики.

Уфа

Darya Yu. Shvets - Postgraduate Student (4th year), Institute of Biochemistry and Genetics.

Ufa

https://orcid.org/0009-0008-6947-0381ИбрагимоваЗ. А.IbragimovaZ. A.

Ибрагимова Зарина Азадовна - м. н. с. лаборатории микробиома человека.

Уфа

Zarina A. Ibragimova - Junior Researcher, Laboratory of the Human Microbiome.

Ufa

https://orcid.org/0009-0005-6666-8497ЗайцеваД. З.ZaicevaD. Z.

Зайцева Диана Земфировна - м. н. с. лаборатории микробиома человека.

Уфа

Diana Z. Zaiceva - Junior Researcher, Laboratory of the Human Microbiome.

Ufa

Башкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationИнститут биохимии и генетики Уфимского федерального исследовательского центра РАНРоссияInstitute of Biochemistry and Genetics of the Ufa Federal Research Center of the Russian Academy of SciencesRussian Federation202622052026112101108Copyright © Павлов В.Н., Гимранова И.А., Газизуллина Г.Р., Швец Д.Ю., Ибрагимова З.А., Зайцева Д.З., 20262026Павлов В.Н., Гимранова И.А., Газизуллина Г.Р., Швец Д.Ю., Ибрагимова З.А., Зайцева Д.З.Pavlov V.N., Gimranova I.A., Gazizullina G.R., Shvets D.Y., Ibragimova Z.A., Zaiceva D.Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.innovmedkub.ru/jour/article/view/1536

Изменения в составе естественного микробиома могут приводить к развитию новообразований, поскольку хронические инфекции, генетическая инкорпорация вирусов и метаболиты микроорганизмов могут потенциально влиять на канцерогенез, в том числе предстательной железы. Исследования с использованием секвенирования позволили обнаружить взаимосвязь между составом микробиома в мочеполовой системе, желудочно-кишечном тракте и полости рта и риском развития, а также прогрессирования рака предстательной железы.

Настоящий обзор посвящён анализу и обобщению современных данных о роли микробиоты в патогенезе рака предстательной железы. Дальнейшее изучение этой темы может привести к улучшению диагностических возможностей и дальнейшему влиянию на парадигмы лечения и профилактики.

Changes in the composition of the native microbiome may contribute to tumor development, as chronic infections, viral genetic integration, and microbial metabolites can potentially influence carcinogenesis, including in the prostate. Studies employing sequencing have revealed associations between the microbiome composition in the genitourinary system, gastrointestinal tract, and oral cavity and the risk of development and progression of prostate cancer.

This review focuses on the analysis and integration of current data on the role of the microbiota in the pathogenesis of prostate cancer. Further investigation in this area may enhance diagnostic capabilities and inform future treatment and prevention paradigms.

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The authors declare that there are no conflicts of interest present.