inovmedИнновационная медицина КубаниInnovative Medicine of Kuban2541-9897Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1inovmed-176Research ArticleТРАНСЛЯЦИОННАЯ МЕДИЦИНАTRANSLATIONAL MEDICINEОБОГАЩЕННАЯ ТРОМБОЦИТАМИ ПЛАЗМА В ЛЕЧЕНИИ ДЛИТЕЛЬНО НЕЗАЖИВАЮЩИХ ЯЗВ НИЖНИХ КОНЕЧНОСТЕЙPLATELET-RICH PLASMA FOR PERSISTENT ULCERS OF THE LOWER LIMBShttps://orcid.org/0000-0002-9766-1811ГилевичИ. В.GilevichI. V.

К. м. н., заведующая лабораторией разработки и изучения новых технологий лечения заболеваний

Cand. of Sci. (Med.), head of the laboratory for development and study of new treatment technologies

350086, Krasnodar, 167, 1st May str.

giliv@list.ruФедоренкоТ. В.FedorenkoT. V.

Биолог лаборатории разработки и изучения новых технологий лечения заболеваний

Biologist of the laboratory for development and study of new treatment technologies

fedorenko.tv@mail.ruКоломийцеваE. А.KolomiytsevaE. A.

Биолог лаборатории разработки и изучения новых технологий лечения заболеваний

Biologist of the laboratory for development and study of new treatment technologies

kmc78@mail.ruФедюшкинВ. В.FedyushkinV. V.

Хирург отделения гнойной хирургии

Surgeon of the department of purulent surgery

vladimirkkb1@mail.ruШубровЭ. Н.ShubrovE. N.

Хирург отделения гнойной хирургии

Surgeon of the department of purulent surgery

erik.nalchanin@icloud.comСлавинскийВ. Г.SlavinskyS. G.

К. м. н., заведующий отделением гнойной хирургии

Cand. of Sci. (Med.), surgeon of the department of purulent surgery

kkb1@mail.ruНаучно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского Министерства здравоохранения Краснодарского краяРоссияScientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, The Krasnodar Krai Ministry of HealthRussian Federation201830122018041724Copyright © Гилевич И.В., Федоренко Т.В., Коломийцева E.А., Федюшкин В.В., Шубров Э.Н., Славинский В.Г., 20182018Гилевич И.В., Федоренко Т.В., Коломийцева E.А., Федюшкин В.В., Шубров Э.Н., Славинский В.Г.Gilevich I.V., Fedorenko T.V., Kolomiytseva E.A., Fedyushkin V.V., Shubrov E.N., Slavinsky S.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.innovmedkub.ru/jour/article/view/176Цель

Цель. Оценить безопасность и эффективность обогащенной тромбоцитами плазмы в комплексном лечении пациентов с длительно незаживающими язвами больших размеров.

Материал и методы

Материал и методы. Описание двух клинических случаев пациентов с длительно незаживающими язвами нижних конечностей, которым выполняли локальную инъекцию аутологичной обогащенной тромбоцитами плазмы (platelet rich plasma, PRP) в рану в сочетании с или без аутодермопластики.

Результаты

Результаты. В первом случае у пациента была трофическая язва после рожистого воспаления без динамики к заживлению на фоне проводимого стандартного лечения. Ему было противопоказано оперативное вмешательство ввиду тяжелой сопутствующей патологии. Больному проведено 6 курсов лечения раны PRP (1 раз в неделю). Краевая эпителизация появилась на 2-й неделе. Через 6 введений отмечено полное заживление раны. Во втором случае пациентка имела длительно незаживающую посттравматическую язву площадью 2%. Была выполнена аутодермопластика с локальным введением PRP. По результатам лечения отмечалось полное приживление трансплантата на 6-е сутки.

Заключение

Заключение. Использование PRP позволит улучшить результаты лечения длительно незаживающих язв нижних конечностей. Представляется крайне важным продолжить работу по применению PRP ввиду отсутствия осложнений и явных противопоказаний у данного метода для проведения всестороннего анализа.

Background

Background. Estimation of safety and efficiency of platelet-rich plasma in complex treatment in patients with persistent large ulcers.

Material and methods

Material and methods. Two clinical cases of patients with long persistent ulcers of the lower extremities that were administered local injections of the autologic platelet-rich plasma in the wound area in combination with or without autodermoplasty.

Results

Results. In the first case the patient had a trophic ulcer after erysipelatous inflammation without dynamics to healing in the setting of the carried treatment. Surgery was contraindicated due to severe accompanying pathology. This patient had 6 PRP courses (once a week). The regional epithelialization appeared on the 2nd week. After 6 injections full wound healing was noted. In the second case the patient had a long persistent post-traumatic ulcer with 2% square. The autodermoplasty with local introduction of PRP was performed. We observed a full graft acceptance on the 6th day.

Conclusion

Conclusion. PRP use will allow to improve outcomes of treatment persistent ulcers of the lower extremities. It represents extremely important to continue work on PRP application due to an absence of complications and obvious contraindications in this method for carrying out comprehensive analysis.

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The authors declare that there are no conflicts of interest present.