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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2500-0268-2019-15-3-62-67</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-213</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Липофилинг. Обзор методики. Современные возможности и перспективы коррекции кожных рубцов</article-title><trans-title-group xml:lang="en"><trans-title>Lipofilling. The review of the technique. Modern opportunities and prospects for dermal scar correction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8452-5936</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеева</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeeva</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергеева Юлия Анатольевна – аспирант кафедры общей и клинической патологической физиологии, врач – челюстно-лицевой хирург, отделение пластической хирургии</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Sergeeva Yulia A. – Postgraduate Student, Department of Common and Clinical Pathophysiology; maxillofacial surgeon</p><p>Krasnodar</p><p> </p></bio><email xlink:type="simple">doctor-sergeeva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0694-9984</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каде</surname><given-names>А. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Kade</surname><given-names>A. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каде Азамат Халидович – д. м. н., профессор, заведующий кафедрой общей и клинической патологической физиологии</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Kade Azamat Kh. – Dr. of Sci. (Med.), Head of Department of Common and Clinical Pathophysiology</p><p>Krasnodar</p></bio><email xlink:type="simple">akh_kade@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9573-4776</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богданов</surname><given-names>С. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogdanov</surname><given-names>S. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Богданов Сергей Борисович – д. м. н., заведующий ожоговым центром; профессор кафедры травматологии, ортопедии и ВПХ</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Bogdanov Sergey B. – Dr. of Sci. (Med.), Head of the Burns Center; Professor of the Department of Orthopedics, Traumatology and Military Field surgery</p><p>Krasnodar</p><p> </p></bio><email xlink:type="simple">bogdanovsb@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7140-0739</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофименко</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimenko</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трофименко Артем Иванович – к. м. н., научный сотрудник, научно-организационный отдел</p><p>350086, Краснодар, ул. 1 Мая, 167</p></bio><bio xml:lang="en"><p>Trofimenko Artem I. – Cand. of Sci. (Med.), Researcher, Scientific Department</p><p>350086, Krasnodar, 1st May str., 167</p></bio><email xlink:type="simple">artemtrofimenko@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ООО ЛДЦ «Клиника Солнечная»; Кубанский государственный медицинский университет Министерства здравоохранения РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University; Klinika Solnechnaya</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кубанский государственный медицинский университет Министерства здравоохранения РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Кубанский государственный медицинский университет Министерства здравоохранения РФ; Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского Министерства здравоохранения Краснодарского края</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского Министерства здравоохранения Краснодарского края</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2019</year></pub-date><volume>0</volume><issue>3</issue><fpage>62</fpage><lpage>67</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сергеева Ю.А., Каде А.Х., Богданов С.Б., Трофименко А.И., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Сергеева Ю.А., Каде А.Х., Богданов С.Б., Трофименко А.И.</copyright-holder><copyright-holder xml:lang="en">Sergeeva Y.A., Kade A.K., Bogdanov S.B., Trofimenko A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/213">https://www.innovmedkub.ru/jour/article/view/213</self-uri><abstract><p>Со времени изобретения липофилинга произошло значительное изменение представлений о роли используемой аутологичной жировой ткани (Ауто ЖТ) от естественного наполнителя дефектов до продукта, стимулирующего регенерацию. Наблюдается значительная эволюция в технике липосакции и процессинга Ауто ЖТ, усовершенствовано материально-техническое и методическое обеспечение процедуры.</p><p>Цель исследования – изучение современных возможностей и перспектив липофилинга при коррекции кожных рубцов. Открытие и изучение роли клеток стромально-васкулярной фракции жировой ткани, в частности мезенхимальных стволовых клеток жировой ткани (МСК ЖТ), способствовало значительному расширению показаний при использовании метода в эстетической медицине. По мере накопления опыта применения липофилинга для коррекции рубцов разработаны новые концепции применения Ауто ЖТ в сочетании с МСК ЖТ, плазмой, обогащенной тромбоцитами (PRP), и факторами роста. Понимание ключевой роли реципиентной зоны в приживлении Ауто ЖТ на рубцах привело к разработке метода чрескожной апоневротомии в комбинации с липофилингом (риготомия). Разработана процедура нанолипофилинга, которую можно считать попыткой изолированного использования липофилинга для стимуляции регенерации и ремоделирования рубцовой ткани. Однако, несмотря на достигнутые успехи, необходимо проведение дальнейших исследований, которые бы позволили подтвердить эффективность метода с позиций доказательной медицины и разработать четкие клинические рекомендации по его применению для лечения кожных рубцов. </p></abstract><trans-abstract xml:lang="en"><p>Since of the invention lipofilling, there was a significant change in ideas of the role used autologous fat tissue (Auto Fat) from natural filler of defects to the product for stimulating regeneration. There was a considerable evolution in technology of liposuction and Auto Fat processing, material and methodical providing of the procedure was improved. Opening and studying role of the stromal-vascular fraction (SVF) of the adipose tissue, in particular mesenchymal stem cells of the adipose tissue (MSC FT), promoted considerable extension of indications while using this method in aesthetic medicine. During experience accumulation of lipofilling application new concepts of application of Auto Fat in combination with MSC FT, platelet-enriched plasma (PRP) and growth factors were developed for scar correction. Understanding of a key role recipient area in succesful engrafting Auto Fat on scars resulted in development of transcutaneous aponeurotomy in a combination with a lipofilling (riggotomy). The procedure of a nanolipofilling which can be considered an attempt of the isolated use of lipofilling for regeneration stimulation and remodeling of cicatricial tissue was developed. However, despite the achieved success, carrying out further researches which would allow to confirm this method efficacy from the point of view evidence-based medicine and develop clear clinical guidelines about its application for treatment of dermal scars would be necessary.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>липофилинг</kwd><kwd>риготомия</kwd><kwd>нанолипофилинг</kwd><kwd>кожный рубец</kwd><kwd>жировая ткань</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lipofilling</kwd><kwd>riggotomy</kwd><kwd>nanolipofilling</kwd><kwd>dermal scar</kwd><kwd>fat tissue</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Simonacci F., et al. Procedure, applications, and outcomes of autologous fat grafting. Annals of Medicine and Surgery. 2017;20:49-60. DOI:10.1016/j.amsu.2017.06.059</mixed-citation><mixed-citation xml:lang="en">Simonacci F., et al. 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