<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2500-0268-2019-16-4-6-11</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-222</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Опыт применения экстракорпоральной мембранной оксигенации в акушерстве и гинекологии</article-title><trans-title-group xml:lang="en"><trans-title>Experience of extracorporeal membrane oxygenation in obstetrics and gynecology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7211-1071</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скопец</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Skopets</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скопец Александр Алексеевич – к. м. н., заведующий отделением анестезиологии и реанимации № 2; доцент кафедры анестезиологии, реаниматологии и трансфузиологии ФПК и ППС</p><p>350086, Краснодар, ул. 1 Мая, 167</p></bio><bio xml:lang="en"><p>Skopets Alexander A. – Cand. of Sci. (Med.), Head of Аnaesthesiology and Resuscitation Department no. 2; Assoсiate Professor of the Department for Аnaesthesiology, Reanimation and Transfusion with advanced training</p><p>350086, Krasnodar, 1st May str., 167</p></bio><email xlink:type="simple">alskop1961@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского Министерства здравоохранения Краснодарского края; Кубанский государственный медицинский университет Министерства здравоохранения РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1;&#13;
Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>4</issue><fpage>6</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Скопец А.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Скопец А.А.</copyright-holder><copyright-holder xml:lang="en">Skopets A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/222">https://www.innovmedkub.ru/jour/article/view/222</self-uri><abstract><sec><title>Цели</title><p>Цели. Все чаще экстракорпоральная мембранная оксигенация (ЭКМО) используется при тяжелой сердечной и легочной недостаточности у гинекологических больных, беременных женщин и пациенток в послеродовом периоде. Важно отметить, что клинические результаты применения методики и особенности ведения такой категории больных оценены недостаточно глубоко. Это исследование представляет опыт применения технологии ЭКМО у пациенток гинекологического и акушерского профиля в перипартальном периоде.</p></sec><sec><title>Методы</title><p>Методы. В исследование были включены гинекологические больные, беременные женщины и пациентки в послеродовом периоде, получавшие поддержку с помощью ЭКМО в отделении анестезиологии и реанимации c 1 ноября 2009 г. по 1 сентября 2019 г. Данные проанализированы ретроспективно. Предварительная задача состояла в том, чтобы охарактеризовать обстоятельства и клинические характеристики пациентов, получавших ЭКМО; описать их ведение во время беременности, при родах и в послеродовом периоде; оценить результаты лечения матерей и плодов и сообщить о кровотечениях и тромботических осложнениях.</p></sec><sec><title>Результаты</title><p>Результаты. За период исследования с помощью ЭКМО было пролечено 7 пациенток акушерско-гинекологического профиля. Среди них – 2 беременные, 4 – послеродовые и 1 – гинекологическая. Средний возраст составил 27,0 лет, средний гестационный срок беременности – 27,5 недель. Пять пациенток (71,4%) были выписаны из лечебного учреждения с полным выздоровлением. Фетальная выживаемость в группе беременных и послеродовых женщин составила 5 (80,8%). Одна пациентка успешно родила с использованием ЭКМО. Геморрагические осложнения развились у 3 человек (42,8%) и были вызваны диссеминированным внутрисосудистым свертыванием. Никаких осложнений у плода, связанных с ЭКМО, не было.</p></sec><sec><title>Выводы</title><p>Выводы. При работе мультидисциплинарной команды опытных специалистов технология ЭКМО может быть использована в гинекологии, у беременных и женщин в послеродовом периоде, перевешивая риски кровотечений или тромбозов, с благоприятными результатами для матери и плода. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objectives</title><p>Objectives. In severe cardiac and pulmonary insufficiency extracorporeal membrane oxygenation (ECMO) is increasingly used in gynecological, pregnant and postpartum patients, although the management of such patients and clinical results remain underestimated. This study presents the experience of ECMO in gynecological and obstetric patients in the peripartal period.</p></sec><sec><title>Methods</title><p>Methods. This study included all obstetric, pregnant or postpartum patients who received ECMO support in the Department of anesthesiology and intensive care unit between 1 November 2009 and 1 September 2019. The data were analyzed retrospectively. The preliminary task was to describe the circumstances and clinical characteristics of patients receiving ECMO, describe the management of such patients during pregnancy, childbirth and the postpartum period, evaluate the results of treatment of mothers and fetuses and report bleeding and thrombotic complications.</p></sec><sec><title>Results</title><p>Results. During the study period, seven obstetric and gynecological patients were treated with ECMO. Including two pregnant, 4 postpartum and 1 gynecological. The mean age was 27.0 years and the average gestational age of pregnant women was 27.5 weeks. Five patients (71.4%) were discharged from the hospital with full recovery. The fetal survival rate in the group of pregnant and postpartum 85 was 5 (80.8%). One patient was successfully delivered to ECMO. Hemorrhagic complications developed in 3 patients (42.8%) and were associated with disseminated intravascular coagulation. There were no complications in the fetus associated with ECMO.</p></sec><sec><title>Summary</title><p>Summary. In the work of a multidisciplinary team of experienced specialists ECMO can be used in gynecology, in pregnant women and in the postpartum period, outweighing the risks of bleeding or thrombosis, with favorable results for the mother and fetus. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>грипп</kwd><kwd>беременность</kwd><kwd>ЭКМО</kwd><kwd>кесарево сечение</kwd><kwd>перипартальная кардиомиопатия</kwd><kwd>кардиогенный шок</kwd></kwd-group><kwd-group xml:lang="en"><kwd>influenza</kwd><kwd>pregnancy</kwd><kwd>ECMO</kwd><kwd>cesarean section</kwd><kwd>peripartal cardiomyopathy</kwd><kwd>cardiogenic shock</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Abrams D, Combes A, Brodie D. Extracorporeal membrane oxygenation in cardiopulmonary disease in adults. J Am Coll Cardiol. 2014;63:2769-78.</mixed-citation><mixed-citation xml:lang="en">Abrams D, Combes A, Brodie D. Extracorporeal membrane oxygenation in cardiopulmonary disease in adults. J Am Coll Cardiol. 2014;63:2769-78.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Paden ML, Conrad SA, Rycus PT, Thiagarajan RR. ELSO RegistryE. Extracorporeal Life Support Organization Registry Report 2012. ASAIO J. 2013;59(3):202–10.</mixed-citation><mixed-citation xml:lang="en">Paden ML, Conrad SA, Rycus PT, Thiagarajan RR. ELSO RegistryE. Extracorporeal Life Support Organization Registry Report 2012. ASAIO J. 2013;59(3):202–10.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators, Davies A, Jones D, et al. Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome. JAMA. 2009;302:1888-95.</mixed-citation><mixed-citation xml:lang="en">Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators, Davies A, Jones D, et al. Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome. JAMA. 2009;302:1888-95.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Peek GJ, Mugford M, Tiruvoipati R, et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet. 2009;374:1351-63.</mixed-citation><mixed-citation xml:lang="en">Peek GJ, Mugford M, Tiruvoipati R, et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet. 2009;374:1351-63.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Patroniti N, Zangrillo A, Pappalardo F, et al. The Italian ECMO network experience during the 2009 influenza A (H1N1) pandemic: preparation for severe respiratory emergency outbreaks. Intensive Care Med. 2011;37:1447-57.</mixed-citation><mixed-citation xml:lang="en">Patroniti N, Zangrillo A, Pappalardo F, et al. The Italian ECMO network experience during the 2009 influenza A (H1N1) pandemic: preparation for severe respiratory emergency outbreaks. Intensive Care Med. 2011;37:1447-57.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Leeper WR, Valdis M, Arntfield R, Ray Guo L. Extracorporeal membrane oxygenation in the acute treatment of cardiovascular collapse immediately post-partum. Interact Cardiovasc Thorac Surg 2013;17:898-9.</mixed-citation><mixed-citation xml:lang="en">Leeper WR, Valdis M, Arntfield R, Ray Guo L. Extracorporeal membrane oxygenation in the acute treatment of cardiovascular collapse immediately post-partum. Interact Cardiovasc Thorac Surg 2013;17:898-9.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma NS, Wille KM, Bellot SC, Diaz-Guzman E. Modern use of extracorporeal life support in pregnancy and postpartum. ASAIO J. 2015;61:110-4.</mixed-citation><mixed-citation xml:lang="en">Sharma NS, Wille KM, Bellot SC, Diaz-Guzman E. Modern use of extracorporeal life support in pregnancy and postpartum. ASAIO J. 2015;61:110-4.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ho YK, Wang CP, Wu YL, Lee TH, Ying TH, Lee MS. Pulmonary embolism after cesarean section and successful treatment with early application of extracorporeal membrane oxygenation system and anticoagulant agents. Taiwan J Obstet Gynecol. 2014;53:273-5.</mixed-citation><mixed-citation xml:lang="en">Ho YK, Wang CP, Wu YL, Lee TH, Ying TH, Lee MS. Pulmonary embolism after cesarean section and successful treatment with early application of extracorporeal membrane oxygenation system and anticoagulant agents. Taiwan J Obstet Gynecol. 2014;53:273-5.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ecker JL, Solt K, Fitzsimons MG, MacGillivray TE. Case records of the Massachusetts General Hospital. Case 40-2012. A 43-year-old woman with cardiorespiratory arrest after a cesarean section. N Engl J Med. 2012;367:2528-36.</mixed-citation><mixed-citation xml:lang="en">Ecker JL, Solt K, Fitzsimons MG, MacGillivray TE. Case records of the Massachusetts General Hospital. Case 40-2012. A 43-year-old woman with cardiorespiratory arrest after a cesarean section. N Engl J Med. 2012;367:2528-36.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nair P, Davies AR, Beca J, et al. Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic. Intensive Care Med. 2011;37:648-54.</mixed-citation><mixed-citation xml:lang="en">Nair P, Davies AR, Beca J, et al. Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic. Intensive Care Med. 2011;37:648-54.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012; 307:2526–33.</mixed-citation><mixed-citation xml:lang="en">ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012; 307:2526–33.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Brodie D, Bacchetta M. Extracorporeal membrane oxygenation for ARDS in adults. N Engl J Med. 2011;365:1905-14.</mixed-citation><mixed-citation xml:lang="en">Brodie D, Bacchetta M. Extracorporeal membrane oxygenation for ARDS in adults. N Engl J Med. 2011;365:1905-14.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Biscotti M, Agerstrand C, Abrams D, et al. One hundred transports on extracorporeal support to an extracorporeal membrane oxygenation center. Ann Thorac Surg. 2015; 100: 34– 9; discussion 39-40.</mixed-citation><mixed-citation xml:lang="en">Biscotti M, Agerstrand C, Abrams D, et al. One hundred transports on extracorporeal support to an extracorporeal membrane oxygenation center. Ann Thorac Surg. 2015; 100: 34– 9; discussion 39-40.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Agerstrand CL, Burkart KM, Abrams DC, Bacchetta MD, Brodie D. Blood conservation in extracorporeal membrane oxygenation for acute respiratory distress syndrome. Ann Thorac Surg. 2015;99:590-5.</mixed-citation><mixed-citation xml:lang="en">Agerstrand CL, Burkart KM, Abrams DC, Bacchetta MD, Brodie D. Blood conservation in extracorporeal membrane oxygenation for acute respiratory distress syndrome. Ann Thorac Surg. 2015;99:590-5.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Chesnutt AN. Physiology of normal pregnancy. Crit Care Clin. 2004;20(4):609-15.</mixed-citation><mixed-citation xml:lang="en">Chesnutt AN. Physiology of normal pregnancy. Crit Care Clin. 2004;20(4):609-15.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">ECMO Registry of the Extracorporeal Life Support Organization, International Summary Report. Available at www. elso.org. Accessed September. 21, 2015.</mixed-citation><mixed-citation xml:lang="en">ECMO Registry of the Extracorporeal Life Support Organization, International Summary Report. Available at www. elso.org. Accessed September. 21, 2015.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Park SH, Chin JY, Choi MS, Choi JH, Choi YJ, Jung KT. Extracorporeal membrane oxygenation saved a mother and her son from fulminant peripartum cardiomyopathy. J Obstet Gynaecol Res. 2014;40:1940-3.</mixed-citation><mixed-citation xml:lang="en">Park SH, Chin JY, Choi MS, Choi JH, Choi YJ, Jung KT. Extracorporeal membrane oxygenation saved a mother and her son from fulminant peripartum cardiomyopathy. J Obstet Gynaecol Res. 2014;40:1940-3.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Cara Agerstrand, MD, Darryl Abrams, MD, Mauer Biscotti, MD, Leslie Moroz, MD,Erika B. Rosenzweig, MD, Mary D’Alton, MD, Daniel Brodie, MD, and Matthew Bacchetta, MD, MBA Extracorporeal Membrane Oxygenation for Cardiopulmonary Failure During Pregnancy and Postpartum. Ann Thorac Surg. 2016;102(3):774-779.</mixed-citation><mixed-citation xml:lang="en">Cara Agerstrand, MD, Darryl Abrams, MD, Mauer Biscotti, MD, Leslie Moroz, MD,Erika B. Rosenzweig, MD, Mary D’Alton, MD, Daniel Brodie, MD, and Matthew Bacchetta, MD, MBA Extracorporeal Membrane Oxygenation for Cardiopulmonary Failure During Pregnancy and Postpartum. Ann Thorac Surg. 2016;102(3):774-779.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
