inovmedИнновационная медицина КубаниInnovative Medicine of Kuban2541-9897Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 110.35401/2500-0268-2019-16-4-66-71inovmed-230Research ArticleОБЗОРЫREVIEWSМикроРНК как терапевтические мишени при нейробластомахMicroRNA as therapeutic targets for neuroblastomashttps://orcid.org/0000-0002-6149-5460БейлерлиО. А.BeylerliO. A.

Бейлерли Озал Арзуманоглы – аспирант кафедры урологии с курсом ИДПО

Республика Башкортостан, Уфа, ул. Ленина, 3 

Beylerli Ozal A. – Рostgraduate Student of Urology Department

450008, 3, Lenina str., Ufa, Republic of Bashkortostan

obeylerli@mail.ruhttps://orcid.org/0000-0002-4965-0835ГареевИ. Ф.GareevI. F.

Гареев Ильгиз Фанилевич – аспирант кафедры нейрохирургии и медицинской реабилитации с курсом ИДПО

Республика Башкортостан, Уфа, ул. Ленина, 3 

Gareev Ilgiz F. – Postgraduate Student, Department of Neurosurgery and Medical Rehabilitation 

450008, 3, Lenina str., Ufa, Republic of Bashkortostan

ilgiz_gareev@mail.ruБашкирский государственный медицинский университет Министерства здравоохранения РФРоссияBashkir State Medical UniversityRussian Federation201930122019046671Copyright © Бейлерли О.А., Гареев И.Ф., 20192019Бейлерли О.А., Гареев И.Ф.Beylerli O.A., Gareev I.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.innovmedkub.ru/jour/article/view/230

Нейробластома – наиболее распространенная внекраниальная солидная опухоль, которая является одной из основных причин смерти от рака у детей в возрасте от 1 до 5 лет. Причем на нее приходится около 15% всей смертности от онкологии в детском возрасте. Новообразование имеет характерные особенности, такие как ранний возраст дебюта заболевания, высокая частота метастазирования при диагностике у пациентов старше 1 года и тенденция к спонтанной регрессии у детей раннего возраста. Хотя и было ранее определено несколько прогностических факторов (возраст, стадия, гистология, наследственность), идентификация неинвазивных биомаркеров для наблюдения за болезнью и мониторинг терапии действительно все еще остаются клинической необходимостью. В обзоре описаны последние данные о микроРНК в нейробластоме с акцентом на те, которые участвуют в прогрессировании опухоли, метастазировании и имеют лекарственную устойчивость. Кроме того, обсуждено их потенциальное применение в терапии этой опухоли.

Neuroblastoma is one of the most common extracranial solid tumors in children. One of the main causes of death from childhood cancer in children aged one to five years, and it accounts for about 15% of all deaths from cancer in children. They have characteristic features, such as an early age of onset, a high frequency of metastasis in the diagnosis of patients older than 1 year and a tendency to spontaneous regression of tumors in young children. Although several prognostic factors were identified (age, stage, histology, heredity), identifying non-invasive biomarkers for disease surveillance and monitoring therapy is indeed still a clinical necessity. In this review, we describe the latest miRNA data in neuroblastoma, with an emphasis on those involved in tumor progression, metastasis, and drug resistance. In addition, we will discuss their potential use in the treatment of this tumor.

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The authors declare that there are no conflicts of interest present.