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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2500-0268-2020-19-3-77-85</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-298</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Ортостатическая гипотония. Часть 2: диагностика и лечение</article-title><trans-title-group xml:lang="en"><trans-title>Orthostatic hypotension. Part 2: diagnosis and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4866-0345</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головина</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovina</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Головина Галина Александровна, к. м. н., врачкардиолог, кардиологическое отделение № 4 </p><p>350086, Краснодар, ул. 1 Мая, 167</p></bio><bio xml:lang="en"><p>Galina A. Golovina, Cand. of Sci. (Med.), Cardiologist, Cardiology Department no. 4 </p><p>ul. 1 Maya, 167, Krasnodar, 350086</p></bio><email xlink:type="simple">ggolovina.70@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6984-5744</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жадан</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhadan</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жадан Ольга Николаевна, врач-невролог, заведующая отделением медицинской реабилитации для пациентов с нарушением функции центральной нервной системы</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Olga N. Zhadan, Neurologist, Head of the Department of Medical Rehabilitation of Patients with Impaired Function of the Central Nervous System</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3596-4275</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заргарян</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zargaryan</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заргарян Карина Александровна, врач-кардиолог, кардиологическое отделение № 4</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Karina A. Zargaryan, Cardiologist, Cardiology Department #4</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2015-3907</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кравченко</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kravchenko</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кравченко Олеся Анатольевна, врач-кардиолог, кардиологическое отделение № 4</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Olesya A. Kravchenko, Cardiologist, Cardiology Department no. 4</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9208-3867</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трипольская</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Tripolskaya</surname><given-names>N. Ye.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трипольская Наталья Евгеньевна, врач-кардиолог, кардиологическое отделение № 4</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Natalya Ye. Tripolskaya, Cardiologist, Cardiology Department no. 4</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского Министерства здравоохранения Краснодарского края</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2020</year></pub-date><volume>0</volume><issue>3</issue><fpage>77</fpage><lpage>85</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Головина Г.А., Жадан О.Н., Заргарян К.А., Кравченко О.А., Трипольская Н.Е., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Головина Г.А., Жадан О.Н., Заргарян К.А., Кравченко О.А., Трипольская Н.Е.</copyright-holder><copyright-holder xml:lang="en">Golovina G.A., Zhadan O.N., Zargaryan K.A., Kravchenko O.A., Tripolskaya N.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/298">https://www.innovmedkub.ru/jour/article/view/298</self-uri><abstract><p>Ортостатическая гипотония (ОГ) чаще всего протекает бессимптомно, в связи с чем выявить ее возможно только при проведении ортостатических проб. Важно определить этиологию ОГ в каждом отдельном случае, так как лечение заболевания, вызвавшего ОГ, позволит улучшить прогноз здоровья пациента. Целью терапии ОГ выступает улучшение функционального состояния больного, уменьшение симптомов и снижение риска падений и обмороков, а не достижение определенных показателей артериального давления. Информированность врачей различных специальностей о способах диагностики ОГ, медикаментозных и немедикаментозных методах ее лечения позволит улучшить качество жизни пациентов, для которых характерно это состояние. Первая часть обзорного исследования, посвященного ортостатической гипотонии, опубликована в №4 журнала «Инновационная медицина Кубани» за 2018 г.</p></abstract><trans-abstract xml:lang="en"><p>Due to its asymptomatic nature, orthostatic hypotension can be diagnosed only by means of orthostatic challenge. One should try to define the causes of orthostatic hypotension in every single case because treating illness that lead to orthostatic hypotension will improve patient’s health outcomes. The main target for therapy should be improving patient’s functional status, reducing orthostatic symptoms as well as risk for falls and syncopes, but not maintaining arterial blood pressure within certain limits. Doctors need to be aware of the methods for diagnosing the orthostatic hypotension to provide patients with the better quality of life. The first part of the systematic review was published in the Innovative Medicine of Kuban, no. 4, 2018.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ортостатическая гипотония</kwd><kwd>обморок</kwd><kwd>ортостатическая проба</kwd></kwd-group><kwd-group xml:lang="en"><kwd>orthostatic hypotension</kwd><kwd>syncope</kwd><kwd>orthostatic challenge</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Brignole M, Alboni P, Benditt DG, et al. Guidelines on management (diagnosis and treatment) of syncope – update 2004. Europace. 2004;6:467–537. PMID: 15519256. doi:10.1016/j.eupc.2004.08.008</mixed-citation><mixed-citation xml:lang="en">Brignole M, Alboni P, Benditt DG, et al. Guidelines on management (diagnosis and treatment) of syncope – update 2004. Europace. 2004;6:467–537. PMID: 15519256. doi:10.1016/j.eupc.2004.08.008</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Task Force for the Diagnosis and Management of Syncope; European Society of Cardiology (ESC); European Heart Rhythm Association (EHRA), et al. Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J. 2009;30:2631–71. PMID: 19713422. PMCID: PMC3295536. doi:10.1093/eurheartj/ehp298</mixed-citation><mixed-citation xml:lang="en">Task Force for the Diagnosis and Management of Syncope; European Society of Cardiology (ESC); European Heart Rhythm Association (EHRA), et al. Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J. 2009;30:2631–71. PMID: 19713422. PMCID: PMC3295536. doi:10.1093/eurheartj/ehp298</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Shen W-K, Sheldon RS, Benditt DG, et al. 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2017;136:e60–e122. PMID: 28280231. doi:10.1161/CIR.0000000000000499</mixed-citation><mixed-citation xml:lang="en">Shen W-K, Sheldon RS, Benditt DG, et al. 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2017;136:e60–e122. PMID: 28280231. doi:10.1161/CIR.0000000000000499</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Brignole M, Moya A, de Lange FJ, et al. 2018 ESC guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39:1883–948. PMID: 29562304. doi:10.1093/eurheartj/ehy037</mixed-citation><mixed-citation xml:lang="en">Brignole M, Moya A, de Lange FJ, et al. 2018 ESC guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39:1883–948. PMID: 29562304. doi:10.1093/eurheartj/ehy037</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011;21:69–72. PMID: 21431947. doi:10.1007/s10286-011-0119-5</mixed-citation><mixed-citation xml:lang="en">Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011;21:69–72. PMID: 21431947. doi:10.1007/s10286-011-0119-5</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Shibao C, Lipsitz LA, Biaggioni I. ASH position paper: evaluation and treatment of orthostatic hypotension. J Clin Hypertens (Greenwich). 2013;15:147–53. PMID: 23458585. doi:10.1111/jch.12062</mixed-citation><mixed-citation xml:lang="en">Shibao C, Lipsitz LA, Biaggioni I. ASH position paper: evaluation and treatment of orthostatic hypotension. J Clin Hypertens (Greenwich). 2013;15:147–153. PMID: 23458585. doi:10.1111/jch.12062</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ricci F, De Caterina R, Fedorowski A. Orthostatic hypotension: epidemiology, prognosis, and treatment. J Am Coll Cardiol. 2015;66:848–60. PMID: 26271068. doi:10.1016/j.jacc.2015.06.1084</mixed-citation><mixed-citation xml:lang="en">Ricci F, De Caterina R, Fedorowski A. Orthostatic hypotension: epidemiology, prognosis, and treatment. J Am Coll Cardiol. 2015;66:848–60. PMID: 26271068. doi:10.1016/j.jacc.2015.06.1084</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Goldstein DS, Sharabi Ye. Neurogenic orthostatic hypotension: a pathophysiological approach. Circulation. 2009;119:139–46. PMID: 19124673. PMCID: PMC4182314. doi:10.1161/CIRCULATIONAHA.108.805887</mixed-citation><mixed-citation xml:lang="en">Goldstein DS, Sharabi Ye. Neurogenic orthostatic hypotension: a pathophysiological approach. Circulation. 2009;119:139–46. PMID: 19124673. PMCID: PMC4182314. doi:10.1161/CIRCULATIONAHA.108.805887</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Под ред. И.И. Дедова, М.В. Шестаковой, А.Ю. Майорова. 8-й выпуск. Сахарный диабет. 2017;20(1S):1–112. doi:10.14341/DM221S1</mixed-citation><mixed-citation xml:lang="en">Dedov II, Shestakova MV, Mayorov AYu (eds). Standards of specialized diabetes care. 8th ed. Diabetes mellitus. 2017;20(1S):1–112. (In Russ.). doi:10.14341/DM221S1</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ ESC guidelines for the management of arterial hypertension. Eur Heart J. 2013;34:2159–219. PMID: 23771844. doi:10.1093/eurheartj/eht151</mixed-citation><mixed-citation xml:lang="en">Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension. Eur Heart J. 2013;34:2159–219. PMID: 23771844. doi:10.1093/eurheartj/eht151</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–104. PMID: 30165516. doi:10.1093/eurheartj/ehy339</mixed-citation><mixed-citation xml:lang="en">Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–104. PMID: 30165516. doi:10.1093/eurheartj/ehy339</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Valbusa F, Labat C, Salvi P, et al. Orthostatic hypotension in very old individuals living in nursing homes: the PARTAGE study. J Hypertens. 2012;30:53–60. PMID: 22080223. doi:10.1097/HJH.0b013e32834d3d73</mixed-citation><mixed-citation xml:lang="en">Valbusa F, Labat C, Salvi P, et al. Orthostatic hypotension in very old individuals living in nursing homes: the PARTAGE study. J Hypertens. 2012;30:53–60. PMID: 22080223. doi:10.1097/HJH.0b013e32834d3d73</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Romero-Ortuno R, O’Connell MD, Finucane C, Soraghan C, Fan ChW, Kenny RA. Insights into the clinical management of the syndrome of supine hypertension – orthostatic hypotension (SH-OH): the Irish Longitudinal Study on Ageing (TILDA). BMC Geriatr. 2013;13:73. PMID: 23855394. PMCID: PMC3716968. doi:10.1186/1471-2318-13-73</mixed-citation><mixed-citation xml:lang="en">Romero-Ortuno R, O’Connell MD, Finucane C, Soraghan C, Fan ChW, Kenny RA. Insights into the clinical management of the syndrome of supine hypertension – orthostatic hypotension (SH-OH): the Irish Longitudinal Study on Ageing (TILDA). BMC Geriatr. 2013;13:73. PMID: 23855394. PMCID: PMC3716968. doi:10.1186/1471-2318-13-73</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Canney M, O’Connell MD, Murphy CM, et al. Single agent antihypertensive therapy and orthostatic blood pressure behaviour in older adults using beat-to-beat measurements: the Irish Longitudinal Study on Ageing. PLoS One. 2016;11:e0146156. PMID: 26730962. PMCID: PMC4701419. doi:10.1371/journal.pone.0146156</mixed-citation><mixed-citation xml:lang="en">Canney M, O’Connell MD, Murphy CM, et al. Single agent antihypertensive therapy and orthostatic blood pressure behaviour in older adults using beat-to-beat measurements: the Irish Longitudinal Study on Ageing. PLoS One. 2016;11:e0146156. PMID: 26730962. PMCID: PMC4701419. doi:10.1371/journal.pone.0146156</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fogari R, Zoppi A, Mugellini A, et al. Efficacy and safety of two treatment combinations of hypertension in very elderly patients. Arch Gerontol Geriatr. 2009;48:401–5. PMID: 18457886. doi:10.1016/j.archger.2008.03.012</mixed-citation><mixed-citation xml:lang="en">Fogari R, Zoppi A, Mugellini A, et al. Efficacy and safety of two treatment combinations of hypertension in very elderly patients. Arch Gerontol Geriatr. 2009;48:401–5. PMID: 18457886. doi:10.1016/j.archger.2008.03.012</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Di Stefano C, Milazzo V, Totaro S, et al. Orthostatic hypotension in a cohort of hypertensive patients referring to a hypertension clinic. J Hum Hypertens. 2015;29:599–603. PMID: 25631221. doi:10.1038/jhh.2014.130</mixed-citation><mixed-citation xml:lang="en">Di Stefano C, Milazzo V, Totaro S, et al. Orthostatic hypotension in a cohort of hypertensive patients referring to a hypertension clinic. J Hum Hypertens. 2015;29:599–603. PMID: 25631221. doi:10.1038/jhh.2014.130</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kamaruzzaman Sh, Watt H, Carson C, Ebrahim Sh. The association between orthostatic hypotension and medication use in the British Women’s Heart and Health Study. Age Ageing. 2010;39:51–6. PMID: 19897539. doi:10.1093/ageing/afp192</mixed-citation><mixed-citation xml:lang="en">Kamaruzzaman Sh, Watt H, Carson C, Ebrahim Sh. The association between orthostatic hypotension and medication use in the British Women’s Heart and Health Study. Age Ageing. 2010;39:51–6. PMID: 19897539. doi:10.1093/ageing/afp192</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Heseltine D, Bramble MG. Loop diuretics cause less postural hypotension than thiazide diuretics in the frail elderly. Curr Med Res Opin. 1988;11:232–5. PMID: 3215040. doi:10.1185/03007998809114241</mixed-citation><mixed-citation xml:lang="en">Heseltine D, Bramble MG. Loop diuretics cause less postural hypotension than thiazide diuretics in the frail elderly. Curr Med Res Opin. 1988;11:232–5. PMID: 3215040. doi:10.1185/03007998809114241</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bird ST, Delaney JA, Brophy JM, Etminan M, Skeldon SC, Hartzema AG. Tamsulosin treatment for benign prostatic hyperplasia and risk of severe hypotension in men aged 40–85 years in the United States: risk window analyses using between and within patient methodology. BMJ. 2013;347:f6320. PMID: 24192967. PMCID: PMC3817852. doi:10.1136/bmj.f6320</mixed-citation><mixed-citation xml:lang="en">Bird ST, Delaney JA, Brophy JM, Etminan M, Skeldon SC, Hartzema AG. Tamsulosin treatment for benign prostatic hyperplasia and risk of severe hypotension in men aged 40–85 years in the United States: risk window analyses using between and within patient methodology. BMJ. 2013;347:f6320. PMID: 24192967. PMCID: PMC3817852. doi:10.1136/bmj.f6320</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Woolcott JC, Richardson KJ, Wiens MO, et al. Metaanalysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169:1952–60. PMID: 19933955. doi:10.1001/archinternmed.2009.357</mixed-citation><mixed-citation xml:lang="en">Woolcott JC, Richardson KJ, Wiens MO, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169:1952–60. PMID: 19933955. doi:10.1001/archinternmed.2009.357</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">de Bruïne ES, Reijnierse EM, Trappenburg MC, et al. Standing up slowly antagonises initial blood pressure decrease in older adults with orthostatic hypotension. Gerontology. 2017;63:137–43. PMID: 27756060. doi:10.1159/000450642</mixed-citation><mixed-citation xml:lang="en">de Bruïne ES, Reijnierse EM, Trappenburg MC, et al. Standing up slowly antagonises initial blood pressure decrease in older adults with orthostatic hypotension. Gerontology. 2017;63:137–43. PMID: 27756060. doi:10.1159/000450642</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Wieling W, van Dijk N, Thijs RD, de Lange FJ, Krediet CT, Halliwill JR. Physical countermeasures to increase orthostatic tolerance. J Intern Med. 2015;277:69–82. PMID: 24697914. doi:10.1111/joim.12249</mixed-citation><mixed-citation xml:lang="en">Wieling W, van Dijk N, Thijs RD, de Lange FJ, Krediet CT, Halliwill JR. Physical countermeasures to increase orthostatic tolerance. J Intern Med. 2015;277:69–82. PMID: 24697914. doi:10.1111/joim.12249</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Jordan J, Shannon JR, Black BK, et al. The pressor response to water drinking in humans: a sympathetic reflex? Circulation. 2000;101:504–9. PMID: 10662747. doi:10.1161/01.cir.101.5.504</mixed-citation><mixed-citation xml:lang="en">Jordan J, Shannon JR, Black BK, et al. The pressor response to water drinking in humans: a sympathetic reflex? Circulation. 2000;101:504–9. PMID: 10662747. doi:10.1161/01.cir.101.5.504</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Jordan J. Acute effect of water on blood pressure. What do we know? Clin Auton Res. 2002;12:250–5. PMID: 12357278. doi:10.1007/s10286-002-0055-5</mixed-citation><mixed-citation xml:lang="en">Jordan J. Acute effect of water on blood pressure. What do we know? Clin Auton Res. 2002;12:250–5. PMID: 12357278. doi:10.1007/s10286-002-0055-5</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Podoleanu C, Maggi R, Brignole M, et al. Lower limb and abdominal compression bandages prevent progressive orthostatic hypotension in elderly persons: a randomized singleblind controlled study. J Am Coll Cardiol. 2006;48:1425–32. PMID: 17010806. doi:10.1016/j.jacc.2006.06.052</mixed-citation><mixed-citation xml:lang="en">Podoleanu C, Maggi R, Brignole M, et al. Lower limb and abdominal compression bandages prevent progressive orthostatic hypotension in elderly persons: a randomized single-blind controlled study. J Am Coll Cardiol. 2006;48:1425–32. PMID: 17010806. doi:10.1016/j.jacc.2006.06.052</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Figueroa JJ, Basford JR, Low PhA. Preventing and treating orthostatic hypotension: a easy as A, B, C. Cleve Clin J Med. 2010;77:298–306. PMID: 20439562. doi:10.3949/ccjm.77a.09118</mixed-citation><mixed-citation xml:lang="en">Figueroa JJ, Basford JR, Low PhA. Preventing and treating orthostatic hypotension: a easy as A, B, C. Cleve Clin J Med. 2010;77:298–306. PMID: 20439562. doi:10.3949/ccjm.77a.09118</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ten Harkel AD, van Lieshout JJ, Wieling W. Treatment of orthostatic hypotension with sleeping in the head-up tilt position, alone and in combination with fludrocortisone. J Intern Med. 1992;232:139–45. PMID: 1506810. doi:10.1111/j.1365-2796.1992.tb00563.x</mixed-citation><mixed-citation xml:lang="en">Ten Harkel AD, van Lieshout JJ, Wieling W. Treatment of orthostatic hypotension with sleeping in the head-up tilt position, alone and in combination with fludrocortisone. J Intern Med. 1992;232:139–45. PMID: 1506810. doi:10.1111/j.1365-2796.1992.tb00563.x</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Omboni S, Smit AA, van Lieshout JJ, Settels JJ, Langewouters GJ, Wieling W. Mechanisms underlying the impairment in orthostatic tolerance after nocturnal recumbency in patients with autonomic failure. Clin Sci (Lond). 2001;101:609–18. PMID: 11724647.</mixed-citation><mixed-citation xml:lang="en">Omboni S, Smit AA, van Lieshout JJ, Settels JJ, Langewouters GJ, Wieling W. Mechanisms underlying the impairment in orthostatic tolerance after nocturnal recumbency in patients with autonomic failure. Clin Sci (Lond). 2001;101:609–18. PMID: 11724647.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Newton JL, Frith J. The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging. Neurology. 2018;91:e652–e656. PMID: 30006412. PMCID: PMC6105042. doi:10.1212/WNL.0000000000005994</mixed-citation><mixed-citation xml:lang="en">Newton JL, Frith J. The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging. Neurology. 2018;91:e652–e656. PMID: 30006412. PMCID: PMC6105042. doi:10.1212/WNL.0000000000005994</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Jankovic J, Gilden JL, Hiner BC, et al. Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine. Am J Med. 1993;95:38–48. PMID: 7687093. doi:10.1016/0002-9343(93)90230-m</mixed-citation><mixed-citation xml:lang="en">Jankovic J, Gilden JL, Hiner BC, et al. Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine. Am J Med. 1993;95:38–48. PMID: 7687093. doi:10.1016/0002-9343(93)90230-m</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Low PhA, Gilden JL, Freeman R, Sheng K-N, McElligott MA. Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study [published correction appears in JAMA. 1997;278:388. doi: 10.1001/jama.1997.03550050050031]. JAMA. 1997;277:1046–51. PMID: 9091692. doi:10.1001/jama.1997.03540370036033</mixed-citation><mixed-citation xml:lang="en">Low PhA, Gilden JL, Freeman R, Sheng K-N, McElligott MA. Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study [published correction appears in JAMA. 1997;278:388. doi: 10.1001/jama.1997.03550050050031]. JAMA. 1997;277:1046–51. PMID: 9091692. doi:10.1001/jama.1997.03540370036033</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Wright RA, Kaufmann HC, Perera R, et al. A doubleblind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology. 1998;51:120–4. PMID: 9674789. doi:10.1212/wnl.51.1.120</mixed-citation><mixed-citation xml:lang="en">Wright RA, Kaufmann HC, Perera R, et al. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology. 1998;51:120–4. PMID: 9674789. doi:10.1212/wnl.51.1.120</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">van Lieshout JJ, ten Harkel AD, Wieling W. Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure. Clin Auton Res. 2000;10:35–42. PMID: 1075642. doi:10.1007/BF02291388</mixed-citation><mixed-citation xml:lang="en">van Lieshout JJ, ten Harkel AD, Wieling W. Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure. Clin Auton Res. 2000;10:35–42. PMID: 1075642. doi:10.1007/BF02291388</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Axelrod FB, Goldberg JD, Rolnitzky L, et al. Fludrocortisone in patients with familial dysautonomia – assessing effect on clinical parameters and gene expression. Clin Auton Res. 2005;15:284–91. PMID: 16032383. doi:10.1007/s10286-005-0288-1</mixed-citation><mixed-citation xml:lang="en">Axelrod FB, Goldberg JD, Rolnitzky L, et al. Fludrocortisone in patients with familial dysautonomia – assessing effect on clinical parameters and gene expression. Clin Auton Res. 2005;15:284–91. PMID: 16032383. doi:10.1007/s10286-005-0288-1</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Finke J, Sagemüller I. Fludrocortisone in the treatment of orthostatic hypotension: ophthalmodynamography during standing (author’s transl). Dtsch Med Wochenschr. 1975;100:1790–2. PMID: 1098888. doi:10.1055/s-0028-1106461</mixed-citation><mixed-citation xml:lang="en">Finke J, Sagemüller I. Fludrocortisone in the treatment of orthostatic hypotension: ophthalmodynamography during standing (author’s transl). Dtsch Med Wochenschr. 1975;100:1790–2. PMID: 1098888. doi:10.1055/s-0028-1106461</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kaufmann H, Freeman R, Biaggioni I, et al. Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial. Neurology. 2014;83:328– 35. PMID: 24944260. PMCID: PMC4115605. doi:10.1212/WNL.0000000000000615</mixed-citation><mixed-citation xml:lang="en">Kaufmann H, Freeman R, Biaggioni I, et al. Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial. Neurology. 2014;83:328–35. PMID: 24944260. PMCID: PMC4115605. doi:10.1212/WNL.0000000000000615</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Hauser RA, Isaacson S, Lisk JP, Hewitt LA, Rowse G. Droxidopa for the short-term treatment of symptomatic neurogenic orthostatic hypotension in Parkinson’s disease (nOH306B). Mov Disord. 2015;30:646–54. PMID: 25487613. doi:10.1002/mds.26086</mixed-citation><mixed-citation xml:lang="en">Hauser RA, Isaacson S, Lisk JP, Hewitt LA, Rowse G. Droxidopa for the short-term treatment of symptomatic neurogenic orthostatic hypotension in Parkinson’s disease (nOH306B). Mov Disord. 2015;30:646–54. PMID: 25487613. doi:10.1002/mds.26086</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Biaggioni I, Freeman R, Mathias CJ, Low Ph, Hewitt LA, Kaufmann H. Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa. Hypertension. 2015;65:101–7. PMID: 25350981. PMCID: PMC4354798. doi:10.1161/HYPERTENSIONAHA.114.04035</mixed-citation><mixed-citation xml:lang="en">Biaggioni I, Freeman R, Mathias CJ, Low Ph, Hewitt L.A., Kaufmann H. Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa. Hypertension. 2015;65:101–7. PMID: 25350981. PMCID: PMC4354798. doi:10.1161/HYPERTENSIONAHA.114.04035</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Hauser RA, Hewitt LA, Isaacson S. Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinson’s disease (NOH306A). J Parkinsons Dis. 2014;4:57–65. PMID: 24326693. doi:10.3233/JPD-130259</mixed-citation><mixed-citation xml:lang="en">Hauser RA, Hewitt LA, Isaacson S. Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinson’s disease (NOH306A). J Parkinsons Dis. 2014;4:57–65. PMID: 24326693. doi:10.3233/JPD-130259</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Isaacson S, Shill HA, Vernino S, Ziemann A, Rowse GJ. Safety and durability of effect with long-term, open-label droxidopa treatment in patients with symptomatic neurogenic orthostatic hypotension (NOH303). J Parkinsons Dis. 2016;6:751–759. PMID: 27636856. doi:10.3233/JPD-160860</mixed-citation><mixed-citation xml:lang="en">Isaacson S, Shill HA, Vernino S, Ziemann A, Rowse GJ. Safety and durability of effect with long-term, open-label droxidopa treatment in patients with symptomatic neurogenic orthostatic hypotension (NOH303). J Parkinsons Dis. 2016;6:751–759. PMID: 27636856. doi:10.3233/JPD-160860</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Singer W, Opfer-Gehrking TL, McPhee BR, Hilz MJ, Bharucha AE, Low PA. Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension. J Neurol Neurosurg Psychiatry. 2003;74:1294–8. PMID: 12933939. PMCID: PMC1738643. doi:10.1136/jnnp.74.9.1294</mixed-citation><mixed-citation xml:lang="en">Singer W, Opfer-Gehrking TL, McPhee BR, Hilz MJ, Bharucha AE, Low PA. Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension. J Neurol Neurosurg Psychiatry. 2003;74:1294–8. PMID: 12933939. PMCID: PMC1738643. doi:10.1136/jnnp.74.9.1294</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Singer W, Sandroni P, Opfer-Gehrking TL, et al. Pyridostigmine treatment trial in neurogenic orthostatic hypotension. Arch Neurol. 2006;63:513–8. PMID: 16476804. doi:10.1001/archneur.63.4.noc50340</mixed-citation><mixed-citation xml:lang="en">Singer W, Sandroni P, Opfer-Gehrking TL, et al. Pyridostigmine treatment trial in neurogenic orthostatic hypotension. Arch Neurol. 2006;63:513–8. PMID: 16476804. doi:10.1001/archneur.63.4.noc50340</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Schreglmann SR, Büchele F, Sommerauer M, et al. Pyridostigmine bromide versus fludrocortisone in the treatment of orthostatic hypotension in Parkinson’s disease – a randomized controlled trial. Eur J Neurol. 2017;24:545–51. PMID: 28224720. doi:10.1111/ene.13260</mixed-citation><mixed-citation xml:lang="en">Schreglmann SR, Büchele F, Sommerauer M, et al. Pyridostigmine bromide versus fludrocortisone in the treatment of orthostatic hypotension in Parkinson’s disease – a randomized controlled trial. Eur J Neurol. 2017;24:545–51. PMID: 28224720. doi:10.1111/ene.13260</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Shibao C, Okamoto LE, Gamboa A, et al. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension. 2010;56:847–51. PMID: 20837887. PMCID: PMC2959129. doi:10.1161/HYPERTENSIONAHA.110.154898</mixed-citation><mixed-citation xml:lang="en">Shibao C, Okamoto LE, Gamboa A, et al. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension. 2010;56:847–51. PMID: 20837887. PMCID: PMC2959129. doi:10.1161/HYPERTENSIONAHA.110.154898</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Gibbons CH, Schmidt P, Biaggioni I, et al. The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol. 2017;264:1567–82. PMID: 28050656. PMCID: PMC5533816. doi:10.1007/s00415-016-8375-x</mixed-citation><mixed-citation xml:lang="en">Gibbons CH, Schmidt P, Biaggioni I, et al. The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol. 2017;264:1567–82. PMID: 28050656. PMCID: PMC5533816. doi:10.1007/s00415-016-8375-x</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Ramirez CE, Okamoto LE, Arnold AC, et al. Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure. Hypertension. 2014;64:1235– 40. PMID: 25185131. PMCID: PMC4231172. doi:10.1161/HYPERTENSIONAHA.114.04225</mixed-citation><mixed-citation xml:lang="en">Ramirez CE, Okamoto LE, Arnold AC, et al. Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure. Hypertension. 2014;64:1235–40. PMID: 25185131. PMCID: PMC4231172. doi:10.1161/HYPERTENSIONAHA.114.04225</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Okamoto LE, Shibao C, Gamboa A, et al. Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in autonomic failure. Hypertension. 2012;59:650–6. PMID: 22311903. PMCID: PMC3312003. doi:10.1161/HYPERTENSIONAHA.111.184812</mixed-citation><mixed-citation xml:lang="en">Okamoto LE, Shibao C, Gamboa A, et al. Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in autonomic failure. Hypertension. 2012;59:650–6. PMID: 22311903. PMCID: PMC3312003. doi:10.1161/HYPERTENSIONAHA.111.184812</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Sakakibara R, Matsuda Sh, Uchiyama T, Yoshiyama M, Yamanishi T, Hattori T. The effect of intranasal desmopressin on nocturnal waking in urination in multiple system atrophy patients with nocturnal polyuria. Clin Auton Res. 2003;13:106–8. PMID: 12720096. doi:10.1007/s10286-003-0052-3</mixed-citation><mixed-citation xml:lang="en">Sakakibara R, Matsuda Sh, Uchiyama T, Yoshiyama M, Yamanishi T, Hattori T. The effect of intranasal desmopressin on nocturnal waking in urination in multiple system atrophy patients with nocturnal polyuria. Clin Auton Res. 2003;13:106–8. PMID: 12720096. doi:10.1007/s10286-003-0052-3</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Shibao C, Gamboa A, Diedrich A, et al. Acarbose, an α-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure. Hypertension. 2007;50:54–61. PMID: 17515447. doi:10.1161/HYPERTENSIONAHA.107.091355</mixed-citation><mixed-citation xml:lang="en">Shibao C, Gamboa A, Diedrich A, et al. Acarbose, an α-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure. Hypertension. 2007;50:54–61. PMID: 17515447. doi:10.1161/HYPERTENSIONAHA.107.091355</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
