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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2500-0268-2022-25-1-19-26</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-502</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Субарахноидальное кровоизлияние вследствие разрыва милиарных аневризм передней циркуляции Виллизиева круга</article-title><trans-title-group xml:lang="en"><trans-title>Subarachnoid hemorrhage due to rupture of very small aneurysms of the anterior part of the circle of Willis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6321-4557</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шнякин</surname><given-names>П. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shnyakin</surname><given-names>P. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шнякин Павел Геннадьевич, д. м. н., заведующий кафедрой травматологии, ортопедии и нейрохирургии с курсом ПО; заместитель руководителя регионального сосудистого центра Краевой клинической больницы г. Красноярска, главный внештатный нейрохирург Министерства здравоохранения Красноярского края</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Pavel G. Shnyakin, Dr. Sci (Med.)., Head of the Department of Traumatology, Orthopedics and Neurosurgery with a course of postgraduate education; Deputy Head of the Regional Vascular Center of Krasnoyarsk Regional Clinical Hospital; Chief freelance neurosurgeon of the Ministry of Health of the Krasnoyarsk Region</p><p>Krasnoyarsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6813-8776</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Усатова</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Usatova</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Усатова Ирина Сергеевна, ассистент кафедры травматологии, ортопедии и нейрохирургии с курсом ПО</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Irina S. Usatova, Assistant of the Department of Traumatology, Orthopedics and Neurosurgery with a course of postgraduate education</p><p>Krasnoyarsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0449-1823</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трубкин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Trubkin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трубкин Алексей Валерьевич, аспирант кафедры травматологии, ортопедии и нейрохирургии с курсом ПО</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Aleksey V. Trubkin, Postgraduate student of the Department of Traumatology, Orthopedics and Neurosurgery with a course of postgraduate education</p><p>Krasnoyarsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1562-6976</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казадаева</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kazadaeva</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казадаева Инна Александровна, ординатор кафедры нервных болезней с курсом ПО</p><p>660022, Красноярск, ул. Партизана Железняка, 1</p></bio><bio xml:lang="en"><p>Inna A. Kazadaeva, Resident of the Department of Nervous Diseases with a course of postgraduate education</p><p>1, Partizana Zheleznyaka str., Krasnoyarsk, 660022</p></bio><email xlink:type="simple">inna.alex913@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2022</year></pub-date><volume>0</volume><issue>1</issue><fpage>19</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шнякин П.Г., Усатова И.С., Трубкин А.В., Казадаева И.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Шнякин П.Г., Усатова И.С., Трубкин А.В., Казадаева И.А.</copyright-holder><copyright-holder xml:lang="en">Shnyakin P.G., Usatova I.S., Trubkin A.V., Kazadaeva I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/502">https://www.innovmedkub.ru/jour/article/view/502</self-uri><abstract><sec><title>Цель</title><p>Цель: Оценить частоту разрывов милиарных церебральных аневризм, особенности периоперационного течения и исходов по сравнению с разрывом аневризм обычной величины.</p></sec><sec><title>Материал и методы</title><p>Материал и методы: Проведен сравнительный анализ группы пациентов с разрывом церебральных милиарных аневризм (n = 18) c группой пациентов с разрывом церебральных аневризм обычного размера (n = 308). Все больные прооперированы в первые 3-е суток от разрыва открытым способом (костно-пластическая трепанация черепа, микрохирургическое клипирование аневризмы). Сопоставлялись пол, возраст пациентов, тяжесть состояния при поступлении, выраженность субарахноидального кровоизлияния, локализация аневризм, коэффициент шейки, время операции, частота интраоперационных разрывов, послеоперационная летальность.</p></sec><sec><title>Результаты</title><p>Результаты: Выявлено, что разрыв милиарных аневризм встречается в 5,5% от всех случаев разрывов церебральных аневризм. Наиболее часто разрыв милиарных аневризм диагностировался у женщин (77,7%), средний возраст – 50,8 года. В большинстве случаев определялись аневризмы передней соединительной артерии (66,6%) с узкой шейкой (средний коэффициент шейки – 2,1). Пациенты с разрывом милиарных аневризм на 7,9% чаще, чем при разрывах аневризм обычного размера, поступали в состоянии суб/декомпенсации (Hunt-Hess IV–V), на 19,6% чаще у них определялось массивное субарахноидальное кровоизлияние (Fisher III). Операции при милиарных аневризмах проходили в среднем на 30 мин быстрее, чем при клипировании аневризм обычного размера, но в два раза чаще осложнялись интраоперационным разрывом (38,8 и 16,5% соответственно). Послеоперационная летальность в группе пациентов с разрывом милиарных аневризм на 5,7% выше, по сравнению с пациентами с разрывом аневризм обычного размера.</p></sec><sec><title>Заключение</title><p>Заключение: Разрыв церебральных милиарных аневризм встречается относительно нечасто. Женщины в возрасте 50–60 лет с милиарными аневризмами передней соединительной артерии с узкой шейкой составляют основную группу таких пациентов. Массивное субарахноидальное кровоизлияние и тяжелое состояние пациентов при поступлении диагностируются наиболее часто при милиарных аневризмах в сравнении с аневризмами обычного размера. Небольшой размер аневризмы и обусловленная этим работа рядом с местом разрыва определяют более частый контактный интраоперационный разрыв при выделении шейки в сравнении с операциями на аневризмах большего размера, что ухудшает исходы лечения в этой группе пациентов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: To assess the frequency of ruptures of very small cerebral aneurysms, features of the perioperative period and outcomes, in comparison with the rupture of ordinarily sized aneurysms.</p></sec><sec><title>Material and methods</title><p>Material and methods: A comparative analysis of the group of patients with ruptured cerebral miliary aneurysms (n = 18) and the group of patients with ruptured cerebral aneurysms of regular size (n = 308) was carried out. All patients underwent open surgery in the first 3 days after the rupture (osteoplastic craniotomy, microsurgical aneurysm clipping). We compared gender, age of patients, severity of the patient’s condition at the moment of admission, severity of subarachnoid hemorrhage, location of aneurysms, aspect ratio, duration of the operation, frequency of intraoperative ruptures, postoperative mortality.</p></sec><sec><title>Results</title><p>Results: It was found that miliary aneurysm rupture occurs in 5.5% of all patients with cerebral aneurysm rupture. The most common cases of rupture of very small aneurysms were in women (77.7%), with a mean age of 50.8 years. Aneurysms of the anterior communicating artery (66.6%) with a narrow neck (average aspect ratio – 2.1) were the most common. Patients with rupture of very small aneurysms were 7.9% more likely to be admitted in a state of subcompensation or decompensation (Hunt-Hess IV–V), they had massive subarachnoid hemorrhage (Fisher III) 19.6% more often than with ruptured aneurysms of regular size. On average, operations in cases of very small aneurysms lasted 30 minutes less than clipping of ordinary aneurysms, but were complicated by intraoperative rupture twice as often (38.8% and 16.5%, respectively). Postoperative mortality in the group of patients with ruptured miliary aneurysms was 5.7% higher than in patients with ruptured aneurysms of regular size.</p></sec><sec><title>Conclusion</title><p>Conclusion: Rupture of cerebral miliary aneurysms is relatively rare. Women of 50–60 years old with very small aneurysms of the anterior communicating artery with a narrow neck constitute the main group of such patients. Massive subarachnoid hemorrhage and severe condition of patients on admission are more common with miliary aneurysms than with ordinarily sized aneurysms. The small size of the aneurysm and the work near the rupture determine the more frequent contact intraoperative rupture when the neck is exposed as compared to operations on larger aneurysms, which negatively affects the treatment outcomes in this group of patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>церебральная аневризма</kwd><kwd>церебральная милиарная аневризма</kwd><kwd>субарахноидальное кровоизлияние</kwd><kwd>клипирование церебральной аневризмы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cerebral aneurysm</kwd><kwd>cerebral very small aneurysm</kwd><kwd>subarachnoid hemorrhage</kwd><kwd>clipping of a cerebral aneurysm</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Крылов В.В., Годков И.М., Дмитриев А.Ю. Интраоперационные факторы риска в хирургии церебральных аневризм. Материалы городской научно-практической конференции. 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