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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2541-9897-2023-26-2-21-27</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-667</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Использование трехмерных сверточных нейронных сетей для выявления интракраниальных аневризм по данным КТ-ангиографии брахиоцефальных артерий</article-title><trans-title-group xml:lang="en"><trans-title>3D convolutional neural networks for detecting intracranial aneurysms on brachiocephalic arteries CTA scans</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6845-5613</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зяблова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Zyablova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зяблова Елена Игоревна, к. м. н., доцент, заведующая рентгеновским отделением; заведующая кафедрой лучевой диагностики № 2 ФПК и ППС</p><p>350086, Краснодар, ул. 1 Мая, 167</p></bio><bio xml:lang="en"><p>Elena I. Zyablova, Cand. Sci. (Med.), Associate Professor, Head of the Radiology Department; Head of Diagnostic Radiology Department No. 2, Faculty of Continuing Professional Development and Retraining</p><p>ulitsa 1 Maya 167, Krasnodar, 350086, Russian Federation</p></bio><email xlink:type="simple">elenazyablova@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6340-127X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синица</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinitsa</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Синица Сергей Геннадьевич, к. техн. н., доцент кафедры информационных технологий</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Sergey G. Sinitsa, Cand. Sci. (Tech.), Associate Professor, Information Technology Department</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-9984-8269</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заяц</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zayats</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Илья Алексеевич Заяц, студент 3-го курса факультета компьютерных технологий и прикладной математики</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Ilya A. Zayats, Student, Faculty of Computer Technologies and Applied Mathematics</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2324-3649</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халафян</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalafyan</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексан Альбертович Халафян, д. техн. н., профессор кафедры анализа данных и искусственного интеллекта</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Alexan A. Khalafyan, Dr. Sci. (Tech.), Professor at the Data Analysis and Artificial Intelligence Department</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4725-4345</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кардаильская</surname><given-names>Д. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Kardailskaya</surname><given-names>D. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кардаильская Дарья Олеговна, врач-рентгенолог; ассистент кафедры лучевой диагностики №2 ФПК и ППС</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Daria O. Kardailskaya, Radiologist; Assistant,Diagnostic Radiology Department No. 2, Faculty of Continuing Professional Development and Retraining</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0572-1395</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Порханов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Porhanov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Порханов Владимир Алексеевич, академик РАН, д. м. н., профессор, главный врач; заведующий кафедрой онкологии с курсом торакальной хирургии ФПК и ППС</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Vladimir A. Porhanov, Academician of the Russian Academy of Sciences, Dr. Sci. (Med.), Professor, Chief Physician; Head of the Oncology Department with the Thoracic Surgery Course, Faculty of Continuing Professional Development and Retraining</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского; Кубанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1; Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кубанский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><fpage>21</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зяблова Е.И., Синица С.Г., Заяц И.А., Халафян А.А., Кардаильская Д.О., Порханов В.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Зяблова Е.И., Синица С.Г., Заяц И.А., Халафян А.А., Кардаильская Д.О., Порханов В.А.</copyright-holder><copyright-holder xml:lang="en">Zyablova E.I., Sinitsa S.G., Zayats I.A., Khalafyan A.A., Kardailskaya D.O., Porhanov V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/667">https://www.innovmedkub.ru/jour/article/view/667</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность: Компьютерно-томографическая ангиография (КТА) является первичным, минимально инвазивным методом визуализации, который проводится с целью диагностики, наблюдения и предоперационного планирования тактики лечения внутричерепных аневризм, однако интерпретация занимает много времени даже у опытных нейрорадиологов. Могут ли обученные нейронные сети повысить производительность врачей при интерпретации медицинских изображений и сократить время постановки диагноза? Насколько эффективна нейронная сеть в выявлении интракраниальных аневризм по данным КТА? На сегодняшний день исследований, посвященных данной теме, крайне мало.</p></sec><sec><title>Цель</title><p>Цель: Оценить диагностическую ценность созданного прототипа сверточной нейронной сети в выявлении интракраниальных аневризм по данным компьютерно-томографической ангиографии брахиоцефальных артерий (БЦА).</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: Исследован прототип трехмерной сверточной нейронной сети, созданный на базе Кубанского государственного университета (г. Краснодар), который определяет вероятность наличия интракраниальных аневризм по данным КТА БЦА. В исследовании проанализированы результаты 451 КТ-ангиографии, выполненной в рентгеновском отделении НИИ – ККБ № 1 им. проф. С.В. Очаповского (г. Краснодар), из которых 205 были с подтвержденными аневризмами интракраниальных артерий и 246 – без аневризм.</p></sec><sec><title>Результаты</title><p>Результаты: Чувствительность прототипа трехсверточной нейронной сети в обнаружении аневризм по данным КТА БЦА составила 85,1%, специфичность – 95,1%, общая точность – 91%.</p></sec><sec><title>Выводы</title><p>Выводы: Использование трехмерных сверточных систем в диагностике позволяет не только с высокой точностью предсказывать наличие аневризм, но и безошибочно их локализовать в более 90% случаев. Получение таких результатов требует подготовки набора данных бóльшего объема.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background: Computed tomography angiography (CTA) is the primary and minimally invasive imaging modality currently used for diagnosis and monitoring of intracranial aneurysms as well as preoperative planning of their treatment. However, its interpretation is time-consuming even for specially trained neuroradiologists. Nowadays little is known whether trained neural networks contribute to analyzing medical images and reduce the time to diagnosis, and how effective they are in detecting intracranial aneurysms according to the CTA findings.</p></sec><sec><title>Objective</title><p>Objective: To assess the diagnostic value of a convolutional neural network prototype in the intracranial aneurysm detection according to the brachiocephalic arteries CTA findings.</p></sec><sec><title>Materials and methods</title><p>Materials and methods: We analyzed the 3D convolutional neural network prototype based at Kuban State University (Krasnodar, Russian Federation).This prototype was to determine the probability of intracranial aneurysms according to the brachiocephalic arteries CTA findings, obtained in the Radiology Department of Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1. The study included 451 CTA scans of 205 patients with confirmed intracranial aneurysms and 246 patients without aneurysms.</p></sec><sec><title>Results</title><p>Results: The sensitivity of the 3D convolutional neural network prototype in the aneurysms detection according to the brachiocephalic arteries CTA findings was 85.1%, the specificity was 95.1%, and the overall accuracy was 91%.</p></sec><sec><title>Conclusions</title><p>Conclusions: The 3D convolutional systems may predict aneurysms with a high accuracy as well as localize them with an accuracy of more than 90%. Such results require a larger dataset.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>компьютерная томография</kwd><kwd>КТ-ангиография</kwd><kwd>интракраниальные аневризмы</kwd><kwd>DICOM</kwd><kwd>машинное обучение</kwd><kwd>сверхточная нейронная сеть</kwd></kwd-group><kwd-group xml:lang="en"><kwd>computed tomography</kwd><kwd>CTA</kwd><kwd>intracranial aneurysms</kwd><kwd>DICOM</kwd><kwd>machine learning</kwd><kwd>high-accuracy neural network</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Зяблова Е.И., Ачмиз Н.З., Ткачев В.В., Порханов В.А. КТ-ангиография брахиоцефальных артерий при неотложной диагностике разрыва аневризм головного мозга. Российский электронный журнал лучевой диагностики. 2022;12(2):65–73. https://doi.org/10.21569/2222-7415-2022-12-2-65-73</mixed-citation><mixed-citation xml:lang="en">Zyablova EI, Achmiz NZ, Tkachev VV, Porhanov VA. Cerebrovascular CT-angiography in the emergency diagnostics of ruptured cerebral aneurysms. Russian Electronic Journal of Radiology. 2022;12(2):65–73. (In Russ.). https://doi.org/10.21569/2222-7415-2022-12-2-65-73</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Turan N, Heider RA, Roy AK, et al. Current perspectives in imaging modalities for the assessment of unruptured intracranial aneurysms: a comparative analysis and review. World Neurosurg. 2018;113:280–292. PMID: 29360591. https://doi.org/10.1016/j.wneu.2018.01.054</mixed-citation><mixed-citation xml:lang="en">Turan N, Heider RA, Roy AK, et al. Current perspectives in imaging modalities for the assessment of unruptured intracranial aneurysms: a comparative analysis and review. World Neurosurg. 2018;113:280–292. PMID: 29360591. https://doi.org/10.1016/j.wneu.2018.01.054</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Yoon NK, McNally S, Taussky P, Park MS. Imaging of cerebral aneurysms: a clinical perspective. Neurovasc Imaging. 2016;2(1). https://doi.org/10.1186/s40809-016-0016-3</mixed-citation><mixed-citation xml:lang="en">Yoon NK, McNally S, Taussky P, Park MS. Imaging of cerebral aneurysms: a clinical perspective. Neurovasc Imaging. 2016;2(1). https://doi.org/10.1186/s40809-016-0016-3</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Jayaraman MV, Mayo-Smith WW, Tung GA, et al. Detection of intracranial aneurysms: multi-detector row CT angiography compared with DSA. Radiology. 2004;230(2):510–518. PMID: 14699177. https://doi.org/10.1148/radiol.2302021465</mixed-citation><mixed-citation xml:lang="en">Jayaraman MV, Mayo-Smith WW, Tung GA, et al. Detection of intracranial aneurysms: multi-detector row CT angiography compared with DSA. Radiology. 2004;230(2):510–518. PMID: 14699177. https://doi.org/10.1148/radiol.2302021465</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bharatha A, Yeung R, Durant D, et al. Comparison of computed tomography angiography with digital subtraction angiography in the assessment of clipped intracranial aneurysms. J Comput Assist Tomogr. 2010;34(3):440–445. PMID: 20498551. https://doi.org/10.1097/RCT.0b013e3181d27393</mixed-citation><mixed-citation xml:lang="en">Bharatha A, Yeung R, Durant D, et al. Comparison of computed tomography angiography with digital subtraction angiography in the assessment of clipped intracranial aneurysms. J Comput Assist Tomogr. 2010;34(3):440–445. PMID: 20498551. https://doi.org/10.1097/RCT.0b013e3181d27393</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lubicz B, Levivier M, François O, et al. Sixty-four-row multisection CT angiography for detection and evaluation of ruptured intracranial aneurysms: interobserver and intertechnique reproducibility. AJNR Am J Neuroradiol. 2007;28(10):1949–1955. PMID: 17898200. PMCID: PMC8134231. https://doi.org/10.3174/ajnr.A0699</mixed-citation><mixed-citation xml:lang="en">Lubicz B, Levivier M, François O, et al. Sixty-four-row multisection CT angiography for detection and evaluation of ruptured intracranial aneurysms: interobserver and intertechnique reproducibility. AJNR Am J Neuroradiol. 2007;28(10):1949–1955. PMID: 17898200. PMCID: PMC8134231. https://doi.org/10.3174/ajnr.A0699</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">White PM, Teasdale EM, Wardlaw JM, Easton V. Intracranial aneurysms: CT angiography and MR angiography for detection prospective blinded comparison in a large patient cohort. Radiology. 2001;219(3):739–749. PMID: 11376263. https://doi.org/10.1148/radiology.219.3.r01ma16739</mixed-citation><mixed-citation xml:lang="en">White PM, Teasdale EM, Wardlaw JM, Easton V. Intracranial aneurysms: CT angiography and MR angiography for detection prospective blinded comparison in a large patient cohort. Radiology. 2001;219(3):739–749. PMID: 11376263. https://doi.org/10.1148/radiology.219.3.r01ma16739</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rajpurkar P, Irvin J, Ball RL, et al. Deep learning for chest radiograph diagnosis: a retrospective comparison of the CheXNeXt algorithm to practicing radiologists.PLoS Med. 2018;15(11):e1002686. PMID: 30457988. PMCID: PMC6245676. https://doi.org/10.1371/journal.pmed.1002686</mixed-citation><mixed-citation xml:lang="en">Rajpurkar P, Irvin J, Ball RL, et al. Deep learning for chest radiograph diagnosis: a retrospective comparison of the CheXNeXt algorithm to practicing radiologists.PLoS Med. 2018;15(11):e1002686. PMID: 30457988. PMCID: PMC6245676. https://doi.org/10.1371/journal.pmed.1002686</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Приходько И.В., Ерогодский Е.А., Кузьмина Д.В., Синица С.Г., Зяблова Е.И., Халафян А.А. Алгоритмы поиска пространственного расположения интракраниальных аневризм. В: Прикладная математика: современные проблемы математики, информатики и моделирования: материалы III всероссийской научно-практической конференции молодых ученых. Т. 1. Краснодарский ЦНТИ – филиал ФГБУ «РЭА» Минэнерго России; 2021:313–320.</mixed-citation><mixed-citation xml:lang="en">Prikhodko IV, Erogodskii EA, Kuzmina DV, Sinitsa SG, Zyablova EI, Khalafyan AA. Algorithms for detection of intracranial aneurysms location. In: Applied Mathematics: Modern Issues of Mathematics, Informatics, and Modeling: Proceedings of III Russian Scientific and Practical Conference for Young Scientists. Vol. 1. Krasnodar Center of Scientific and Technical Information – branch of Russian Energy Agency of the Ministry of Energy of Russia; 2021:313–320. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">UCAS Japan Investigators, Morita A, Kirino T, et al. The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med. 2012;366(26):2474–2482. PMID: 22738097. https://doi.org/10.1056/NEJMoa1113260</mixed-citation><mixed-citation xml:lang="en">UCAS Japan Investigators, Morita A, Kirino T, et al. The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med. 2012;366(26):2474–2482. PMID: 22738097. https://doi.org/10.1056/NEJMoa1113260</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Гудфеллоу Я., Бенджио И., Курвилль А. Глубокое обучение. Пер. с анг. А.А. Слинкина. 2-е изд., испр. ДМК Пресс; 2018.</mixed-citation><mixed-citation xml:lang="en">Goodfellow I, Bengio Y, Courville A. Deep Learning. Slinkin AA, trans. 2nd rev ed. DMK Press; 2018. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Николенко С., Кадурин А., Архангельская Е. Глубокое обучение. Питер; 2018.</mixed-citation><mixed-citation xml:lang="en">Nikolenko S, Kadurin A, Arkhangelskaya E. Deep Learning. Piter; 2018. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Nikolenko S, Kadurin A, Arkhangelskaya E. Deep Learning. Piter; 2018. (In Russ.).</mixed-citation><mixed-citation xml:lang="en">Zyablova EI, Tkachev VV, Porhanov VA. CT angiography for detecting the cause of intracranial hemorrhage in the emergency department. Innovative Medicine of Kuban. 2021;(1):34–38. (In Russ.). https://doi.org/10.35401/2500-0268-2021-21-1-34-38</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Зяблова Е.И., Ткачев В.В., Порханов В.А. Вклад КТангиографии в верификацию источника нетравматического внутричерепного кровоизлияния в условиях экстренного приемного покоя. Инновационная медицина Кубани. 2021;(1):34–38. https://doi.org/10.35401/2500-0268-2021-21-1-34-38</mixed-citation><mixed-citation xml:lang="en">Tomandl BF, Hammen T, Klotz E, Ditt H, Stemper B, Lell M. Bone-subtraction CT angiography for the evaluation of intracranial aneurysms. AJNR Am J Neuroradiol. 2006;27(1):55–59. PMID: 16418356. PMCID: PMC7976055.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tomandl BF, Hammen T, Klotz E, Ditt H, Stemper B, Lell M. Bone-subtraction CT angiography for the evaluation of intracranial aneurysms. AJNR Am J Neuroradiol. 2006;27(1):55–59. PMID: 16418356. PMCID: PMC7976055.</mixed-citation><mixed-citation xml:lang="en">Shi WY, Li YD, Li MH, et al. 3D rotational angiography with volume rendering: the utility in the detection of intracranial aneurysms. Neurol India. 2010;58(6):908–913. PMID: 21150058. https://doi.org/10.4103/0028-3886.73743</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Shi WY, Li YD, Li MH, et al. 3D rotational angiography with volume rendering: the utility in the detection of intracranial aneurysms. Neurol India. 2010;58(6):908–913. PMID: 21150058. https://doi.org/10.4103/0028-3886.73743</mixed-citation><mixed-citation xml:lang="en">Lin N, Ho A, Gross BA, et al. Differences in simple morphological variables in ruptured and unruptured middle cerebral artery aneurysms. J Neurosurg. 2012;117(5):913–919. PMID: 22957531. https://doi.org/10.3171/2012.7.JNS111766</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Lin N, Ho A, Gross BA, et al. Differences in simple morphological variables in ruptured and unruptured middle cerebral artery aneurysms. J Neurosurg. 2012;117(5):913–919. PMID: 22957531. https://doi.org/10.3171/2012.7.JNS111766</mixed-citation><mixed-citation xml:lang="en">Villablanca JP, Jahan R, Hooshi P, et al. Detection and characterization of very small cerebral aneurysms by using 2D and 3D helical CT angiography. AJNR Am J Neuroradiol. 2002;23(7):1187–1198. PMID: 12169479. PMCID: PMC8185733.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Villablanca JP, Jahan R, Hooshi P, et al. Detection and characterization of very small cerebral aneurysms by using 2D and 3D helical CT angiography. AJNR Am J Neuroradiol. 2002;23(7):1187–1198. PMID: 12169479. PMCID: PMC8185733.</mixed-citation><mixed-citation xml:lang="en">Villablanca JP, Jahan R, Hooshi P, et al. Detection and characterization of very small cerebral aneurysms by using 2D and 3D helical CT angiography. AJNR Am J Neuroradiol. 2002;23(7):1187–1198. PMID: 12169479. PMCID: PMC8185733.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
