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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2541-9897-2023-26-2-71-79</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-675</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Анализ возможности ультразвукового исследования и цитологии в дифференциальной диагностике новообразований больших слюнных желез</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of ultrasonography and cytology potential in differential diagnosis of major salivary gland neoplasms</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6291-9026</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Польшиков</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Polshikov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Польшиков Сергей Владимирович, врач ультразвуковой диагностики, отделение ультразвуковой диагностики</p><p>350086, Краснодар, ул. 1 Мая, 167</p></bio><bio xml:lang="en"><p>Sergey V. Polshikov, Diagnostic Medical Sonographer, Ultrasound Unit</p><p>ulitsa 1 Maya 167, Krasnodar, 350086, Russian Federation</p></bio><email xlink:type="simple">sergey.polshikov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1508-203X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катрич</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Katrich</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Катрич Алексей Николаевич, к. м. н., заведующий отделением ультразвуковой диагностики; доцент кафедры хирургии № 1, факультет повышения квалификации и профессиональной переподготовки специалистов</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Aleksey N. Katrich, Cand. Sci. (Med.), Head of the Ultrasound Unit; Assistant Professor, Surgery Department No. 1; Faculty of Continuing Professional Development and Retraining</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9017-9432</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ветшева</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vetsheva</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ветшева Наталья Николаевна, д. м. н., профессор кафедры ультразвуковой диагностики</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia N. Vetsheva, Dr. Sci. (Med.), Professor at the Diagnostic Ultrasound Department</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского; Кубанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1; Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><fpage>71</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Польшиков С.В., Катрич А.Н., Ветшева Н.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Польшиков С.В., Катрич А.Н., Ветшева Н.Н.</copyright-holder><copyright-holder xml:lang="en">Polshikov S.V., Katrich A.N., Vetsheva N.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/675">https://www.innovmedkub.ru/jour/article/view/675</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность: Опухоли слюнных желез (СЖ) составляют до 5% всех новообразований головы и шеи. Ультразвуковое исследование (УЗИ) является одним из основных методов инструментальной диагностики патологии СЖ, однако существует множество вопросов относительно возможностей метода. Цитологический анализ биоптата, полученного тонкоигольной аспирационной биопсией (ТАПБ), считается основным методом, однако его роль в дифференциальной диагностике остается достаточно спорной.</p></sec><sec><title>Цель</title><p>Цель: На основании морфологически верифицированных данных выделить и изучить дифференциально-диагностическую эффективность основных УЗ-признаков новообразований больших слюнных желез, а также результаты ТАПБ в диагностике доброкачественных и злокачественных новообразований СЖ.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: В группе из 220 пациентов проведен ретроспективный анализ с расчетом чувствительности, специфичности и точности качественных УЗ-признаков новообразований СЖ, а также анализ эффективности ТАПБ. Сравнение достоверности результатов выполнено на основании расчета эмпирического χ-квадрата Пирсона.</p></sec><sec><title>Результаты</title><p>Результаты: Частыми УЗ-признаками доброкачественных новообразований СЖ были отмечены: четкий контур (97,5%) и сниженная эхогенность (72,7%); злокачественных – четкий (76,7%) и неровный контур (72,1%), сниженная эхогенность (69,8%). Чувствительность и специфичность ТАПБ в диагностике доброкачественных новообразований составили 75,5 и 53,6% соответственно, злокачественных – 50 и 94% соответственно. Значения χ-квадрата Пирсона для признака «четкий контур» имели значимые различия в пользу доброкачественных новообразований.</p></sec><sec><title>Обсуждение</title><p>Обсуждение: Доброкачественные и злокачественные новообразования СЖ часто имеют сходную ультразвуковую картину. Существенным диагностическим показателем злокачественных новообразований является признак «неровный контур». Сравнение эффективности цитологической дифференцировки добро- и злокачественных новообразований отражает высокие показатели специфичности и точности в диагностике злокачественных опухолей.</p></sec><sec><title>Заключение</title><p>Заключение: Значимые УЗ-признаки в дифференциации доброкачественных новообразований – «четкий контур» и «сниженная эхогенность», а злокачественных новообразований – «неровный контур». Цитологическая диагностика новообразований больших СЖ применима в качестве метода первичной морфологии, но в половине случаев не позволяет установить природу и тип опухоли.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background: Salivary gland tumors account for up to 5% of all head and neck neoplasms. Ultrasonography is one of the main diagnostic modalities for the salivary gland pathology; however, its diagnostic potential is under scrutiny. Fine needle aspiration cytology is considered the main diagnostic method, although its role in the differential diagnosis is disputable.</p></sec><sec><title>Objective</title><p>Objective: To identify, based on morphology results, the effectiveness of the main ultrasonographic signs indicating major salivary gland neoplasms in the differential diagnosis and study these signs, to evaluate the effectiveness of fine needle aspiration in the diagnosis of benign and malignant major salivary gland neoplasms.</p></sec><sec><title>Materials and methods</title><p>Materials and methods: This retrospective study evaluated a group of 220 patients. We calculated sensitivity, specificity, and accuracy of qualitative ultrasonographic signs of salivary gland neoplasms, analyzed the fine needle aspiration effectiveness, and compared results accuracy by calculating Pearson’s empirical χ-square.</p></sec><sec><title>Results</title><p>Results: Common ultrasonographic signs of benign salivary gland neoplasms included a clear contour (97.5%) and decreased echogenicity (72.7%). Malignant tumors frequently presented with a clear contour (76.7%), uneven contour (72.1%), and decreased echogenicity (69.8%). Fine needle aspiration sensitivity and specificity in the diagnosis of benign neoplasms were 75.5% and 53.6%, respectively. Fine needle aspiration sensitivity and specificity in respect of malignant tumors were 50% and 94%, respectively. Pearson’s χ-square value for the clear contour had significant differences in favor of benign neoplasms.</p></sec><sec><title>Discussion</title><p>Discussion: Benign and malignant salivary gland neoplasms often have a similar ultrasonographic pattern. A significant diagnostic sign of malignant tumors is the uneven contour. We compared the effectiveness of cytological differentiation between benign and malignant neoplasms and found high rates of specificity and accuracy for malignant tumor diagnosis.</p></sec><sec><title>Conclusions</title><p>Conclusions: Clear contour and decreased echogenicity are significant ultrasonographic signs in the differentiation of benign neoplasms. Uneven contour is a significant differentiating factor for malignant neoplasms. Cytology can be used for initial morphology in diagnosing major salivary gland neoplasms, but in half of the cases it fails to identify the nature and type of the tumor.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>новообразования больших слюнных желез</kwd><kwd>ультразвуковая диагностика</kwd><kwd>тонкоигольная биопсия</kwd><kwd>цитология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>major salivary gland neoplasms</kwd><kwd>ultrasonography</kwd><kwd>fine needle aspiration</kwd><kwd>cytology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Пачес А.И., Таболиновская Т.Д. Опухоли слюнных желез. Практическая медицина; 2009.</mixed-citation><mixed-citation xml:lang="en">Paches AI, Tabolinovskaya TD. Salivary Gland Tumors. Prakticheskaya Meditsina; 2009. 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