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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inovmed</journal-id><journal-title-group><journal-title xml:lang="ru">Инновационная медицина Кубани</journal-title><trans-title-group xml:lang="en"><trans-title>Innovative Medicine of Kuban</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2541-9897</issn><publisher><publisher-name>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35401/2541-9897-2023-26-3-105-113</article-id><article-id custom-type="elpub" pub-id-type="custom">inovmed-726</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Клеточная терапия свищей верхних дыхательных путей</article-title><trans-title-group xml:lang="en"><trans-title>Cell Therapy for Upper Respiratory Tract Fistulas</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4572-4750</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поляков</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Polyakov</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Игорь Станиславович Поляков, к. м. н., заведующий отделением, доцент</p><p>отделение онкологии</p><p>кафедра онкологии с курсом торакальной хирургии ФКП и ППС</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Igor S. Polyakov, Cand. Sci. (Med.), Head of the Unit, Associate Professor</p><p>Oncology Unit</p><p>Faculty of Continuing Professional Development and Retraining</p><p>Oncology Department with the Thoracic Surgery Course</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0572-1395</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Порханов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Porhanov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимир Алексеевич Порханов, академик РАН, д. м. н., профессор, главный врач, заведующий кафедрой</p><p>кафедра онкологии с курсом торакальной хирургии ФКП и ППС</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Vladimir A. Porhanov, Academician of the Russian Academy of Sciences, Dr. Sci. (Med.), Professor, Chief Physician, Head of the Department</p><p>Faculty of Continuing Professional Development and Retraining</p><p>Oncology Department with the Thoracic Surgery Course</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3290-1183</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коваленко</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovalenko</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Львович Коваленко, заведующий отделением</p><p>отделение торакальной хирургии № 1</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Alexey L. Kovalenko, Head of Unit</p><p>Thoracic Surgery Unit No. 1</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6720-0355</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потапова</surname><given-names>В. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Potapova</surname><given-names>V. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Валентина Рафаиловна Потапова, студент 5-го курса</p><p>лечебный факультет</p><p>350063</p><p>ул. Седина, 4</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Valentina R. Potapova, 5th Year Student</p><p>Faculty of General Medicine</p><p>350063</p><p>ulitsa M. Sedina 4</p><p>Krasnodar</p></bio><email xlink:type="simple">giliv@list.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С. В. Очаповского; Кубанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1; Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С. В. Очаповского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Кубанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2023</year></pub-date><volume>0</volume><issue>3</issue><fpage>105</fpage><lpage>113</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Поляков И.С., Порханов В.А., Коваленко А.Л., Потапова В.Р., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Поляков И.С., Порханов В.А., Коваленко А.Л., Потапова В.Р.</copyright-holder><copyright-holder xml:lang="en">Polyakov I.S., Porhanov V.A., Kovalenko A.L., Potapova V.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.innovmedkub.ru/jour/article/view/726">https://www.innovmedkub.ru/jour/article/view/726</self-uri><abstract><p>   Свищи различной этиологии являются одним из тяжелых и опасных для жизни заболеваний верхних дыхательных путей. Наиболее часто они возникают вследствие несостоятельности культи бронха после резецирующих операций на легких, как правило, пневмонэктомий. Частота развития данного осложнения составляет 3–4 %, а летальность достигает 12,5–71,2 %. Несмотря на то, что на сегодняшний день описано множество устройств и методов, окончательное лечение обычно включает закрытие свищевого хода путем хирургического вмешательства. Стандартные хирургические подходы сопряжены со значительной заболеваемостью и смертностью и не являются надежными или достаточно успешными. В последние годы особое внимание уделяется клеточным технологиям, которые направлены на стимуляцию процессов заживления ткани, и поэтому могут рассматриваться как возможный потенциальный способ лечения. В текущем обзоре представлены современные тенденции в лечении бронхиальных свищей с помощью клеточной терапии. В работе приведены клинические примеры лечения бронхиальных свищей согласно протоколу исследования, разработанному в нашей клиники. Несмотря на то, что клинический опыт ограничен в связи с небольшом количеством пациентов, полученные знания о безопасности и переносимости будут способствовать планированию будущих более крупных испытаний по использованию инновационных методов для дальнейшего улучшения клинических результатов.</p></abstract><trans-abstract xml:lang="en"><p>   Fistulas of various etiologies are one of the severe and life-threatening diseases of the upper respiratory tract. The most common cause is bronchial stump failure after pulmonary resection, usually pneumonectomy. The incidence and mortality of this complication is 3 %-4 % and 12.5 %-71.2 %, respectively. Despite the fact that many devices and methods have been described to date, it is usually treated with surgical closure. Standard surgical approaches are associated with significant morbidity and mortality and are not reliably successful. In recent years, cell therapies aimed to stimulate tissue healing rose to prominence and can be considered a potential treatment method. We review current trends in bronchopleural fistula treatment using cell therapy and report cases of the bronchopleural fistula treatment according to the research protocol developed in our clinic. Although clinical experience is quite limited owing to a small number of patients in the most studies, the information on safety and tolerance can help plan future larger trials with innovative methods to further improve clinical results.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>свищи верхних дыхательных путей</kwd><kwd>клеточная терапия</kwd><kwd>стволовые клетки</kwd><kwd>фибробласты</kwd><kwd>плазма</kwd><kwd>обогащенная тромбоцитами</kwd></kwd-group><kwd-group xml:lang="en"><kwd>upper respiratory tract fistulas</kwd><kwd>cell therapy</kwd><kwd>stem cells</kwd><kwd>fibroblasts</kwd><kwd>platelet-rich plasma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mazzella A, Pardolesi A, Maisonneuve P, et al. Bronchopleural fistula after pneumonectomy: risk factors and management, focusing on open-window thoracostomy. Semin Thorac Cardiovasc Surg. 2018;30(1):104–113. 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