Parathyroid hormone-related protein as predictor of urolithiasis disease development
https://doi.org/10.35401/2500-0268-2020-17-1-41-46
Abstract
Background. The present article studies a possible role of parathyroid hormone-related protein (PTHrP) in urolithiasis pathogenesis.
Aim. To consider PTHrP level as a predictor of the urolithiasis development.
Material and Methods. We presented an analysis of treatment in 79 patients with primary and recurrent nephrolithiasis that had underwent surgical treatment in the Uronephrological Center of Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, Krasnodar from 2017 to 2019. All observed patients were divided in two groups: patients with primary and recurrent nephrolithiasis. A group of 10 relatively healthy people was included in the study as well. All patients and conditionally healthy people had a test for blood parameters; in particular, the level of parathyroid hormone-related protein was assessed in order to compare the indicators in all three groups.
Conclusions. The PTHrP level was showed to be statistically significantly different in patients with urolithiasis from the group with relatively healthy people. Groups with primary and recurrent nephrolithiasis show not difference in the level of PTHrP. Further studies are necessary to consider this protein as one of the predictors of urolithiasis and study its role in the pathogenesis of nephrolithiasis.
About the Authors
A. A. Budanov
Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1
Russian Federation
Russian Federation
Artem A. Budanov, Urologist of Urology Department; Postgraduate Student of Urology Department
4, Sedina str., Krasnodar, 350063
V. L. Medvedev
Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1
Russian Federation
Russian Federation
Vladimir L. Medvedev, Dr. of Sci. (Med.), Professor, Deputy Chief Doctor on Urology; Head of Regional Uronephrologic Center, Chief External Urologist of Health Care Ministry of Krasnodar Region, Head of Urology Department
A. N. Kurzanov
Kuban State Medical University
Russian Federation
Russian Federation
Anatoly N. Kurzanov, Dr. of Sci. (Med.), Professor, Department of Clinical Pharmacology and Functional Diagnostics, Department of Fundamental and Clinical Biochemistry
A. A. Basov
Kuban State Medical University
Russian Federation
Russian Federation
Aeksandr A. Basov, Professor of Fundamental and Clinical Biochemistry
G. A. Palaguta
Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1
Russian Federation
Russian Federation
Georgy A. Palaguta, Urologist of Urology Department; Teaching Assistant of Urology Department
T. V. Rusinova
Kuban State Medical University
Russian Federation
Russian Federation
Tatyana V. Rusinova, Cand. of Sci. (Biol.), Researcher, Сentral Research Laboratory
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Review
For citations:
Budanov A.A., Medvedev V.L., Kurzanov A.N., Basov A.A., Palaguta G.A., Rusinova T.V. Parathyroid hormone-related protein as predictor of urolithiasis disease development. Innovative Medicine of Kuban. 2020;(1):41-46. (In Russ.) https://doi.org/10.35401/2500-0268-2020-17-1-41-46
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