Application of Spider Silk-Based Materials in Regenerative Medicine: From In Vivo Studies to Clinical Use
R. A. Zamanova,
S. V. Piatnitskaia,
A. I. Fairushina,
Sh. M. Safin,
V. A. Smirnov,
M. V. Lebenstein-Gumovski,
E. D. Grigorevskiy,
A. A. Grin,
V. V. Krylov,
V. N. Pavlov https://doi.org/10.35401/2541-9897-2026-11-1-123-131
Abstract
This review examines the use of spider-silk-based materials in regenerative medicine. Spider silk possesses a unique combination of mechanical and biological properties, making it a promising biomaterial for tissue engineering. An analysis of in vivo studies in animal models and the first clinical trials is presented, demonstrating the ability of spider silk to direct cell growth, accelerate wound healing, and promote peripheral nerve regeneration. The prospects for large-scale production of spider silk and its medical applications are discussed.
Supporting agencies: This work was supported by Bashkir State Medical University Strategic Academic Leadership Program (PRIORITY-2030).
About the Authors
R. A. Zamanova
Bashkir State Medical University
Russian Federation
Russian Federation
Rozalia A. Zamanova - Junior Researcher, Bioprinting Laboratory, Institute of Fundamental Medicine, Bashkir State Medical University.
3 Lenina St., Ufa, 450008
S. V. Piatnitskaia
Bashkir State Medical University
Russian Federation
Russian Federation
Svetlana V. Piatnitskaia - Cand. Sci. (Med.), Associate Professor, Department of Internal Medicine, Head of the Bioprinting Laboratory, Institute of Fundamental Medicine, Bashkir State Medical University.
Ufa
A. I. Fairushina
Bashkir State Medical University
Russian Federation
Russian Federation
Adelia I. Fairushina - Junior Researche, the Bioprinting Laboratory, Institute of Fundamental Medicine, Bashkir State Medical University.
Ufa
Sh. M. Safin
Bashkir State Medical University
Russian Federation
Russian Federation
Shamil M. Safin - Dr. Sci. (Med.), Associate Professor, Head of the Department of Neurosurgery with the Course of Medical Rehabilitation of the Institute of Additional Professional Training, Bashkir State Medical University.
Ufa
V. A. Smirnov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Vladimir A. Smirnov - Senior Researcher, Department of Emergency Neurosurgery, N.V. Sklifosovsky Research Institute for Emergency Medicine.
Moscow
M. V. Lebenstein-Gumovski
Bashkir State Medical University; N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Mikhail V. Lebenstein-Gumovski - Cand. Sci. (Med.), Senior Researcher, Neurosurgeon, Department of Emergency Neurosurgery, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor, Department of Neurosurgery with the Course of Medical Rehabilitation of the Institute of Additional Professional Training, Bashkir State Medical University.
Moscow; Ufa
E. D. Grigorevskiy
Russian Сenter of Neurology and Neurosciences
Russian Federation
Russian Federation
Evgeny D. Grigorevskiy - Neurosurgeon, 2-nd Neurosurgery Department, Russian Center of Neurology and Neurosciences.
Moscow
A. A. Grin
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Andrey A. Grin - Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Emergency Neurosurgery, N.V. Sklifosovsky Research Institute for Emergency Medicine.
Moscow
V. V. Krylov
N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Сenter of Neurology and Neurosciences; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Vladimir V. Krylov - Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Department of Fundamental Neurosurgery, Pirogov Russian National Research Medical University; Chief Researcher, Department of Emergency Neurosurgery, N.V. Sklifosovsky Research Institute for Emergency Medicine; Head of the Institute of Functional Neurosurgery, Russian Center of Neurology and Neurosciences.
Moscow
V. N. Pavlov
Bashkir State Medical University
Russian Federation
Russian Federation
Valentin N. Pavlov - Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Department of Urology and Oncology, Bashkir State Medical University.
Ufa
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Review
For citations:
Zamanova R.A., Piatnitskaia S.V., Fairushina A.I., Safin Sh.M., Smirnov V.A., Lebenstein-Gumovski M.V., Grigorevskiy E.D., Grin A.A., Krylov V.V., Pavlov V.N. Application of Spider Silk-Based Materials in Regenerative Medicine: From In Vivo Studies to Clinical Use. Innovative Medicine of Kuban. 2026;11(1):123-131. (In Russ.) https://doi.org/10.35401/2541-9897-2026-11-1-123-131
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