Radiologic Diagnosis of Toxic Injury to Spinal Cord and Peripheral Nervous System as an Immune-Mediated Complication of Antitumor Therapy
Abstract
Immunotherapy represents a significant breakthrough in modern oncology, being successfully used in the treatment of various malignant neoplasms including those at advanced metastatic stages. This approach has demonstrates impressive therapeutic outcomes in the management of cancer; however, in certain cases, it may lead to the development of atypical reactions known as immune-related adverse events (irAEs). Toxic injury to the spinal cord and peripheral nervous system resulting from complications of antitumor therapy constitutes a serious clinical challenge. Among particularly relevant manifestations are demyelinating disorders, myelitis, Guillain-Barré syndrome, cranial neuropathies, plexopathies, and myositis. Timely detection of these complications using imaging modalities is essential for improving prognosis and clinical outcomes in patients receiving immunotherapy.
About the Authors
A. E. Gerasyuta
Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1; Kuban State Medical University
Russian Federation
Russian Federation
Anna E. Gerasyuta, Radiologist, Radiology Department; Assistant Professor, Radiology Department No. 2
167 1 Maya St., Krasnodar, 350086
E. Yu. Krivitskaya
Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1; Kuban State Medical University
Russian Federation
Russian Federation
Elena Yu. Krivitskaya, Radiologist, Radiology Department; Assistant Professor, Radiology Department No. 2
Krasnodar
A. E. Khakhileva
Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1
Russian Federation
Russian Federation
Anastasia E. Khakhileva, Radiologist, Radiology Department
Krasnodar
V. A. Porhanov
Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1; Kuban State Medical University
Russian Federation
Russian Federation
Vladimir A. Porhanov, Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Chief Physician; Head of the Oncology Department with the Thoracic Surgery Course, Faculty of Continuing Professional Development and Retraining
Krasnodar
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Review
For citations:
Gerasyuta A.E., Krivitskaya E.Yu., Khakhileva A.E., Porhanov V.A. Radiologic Diagnosis of Toxic Injury to Spinal Cord and Peripheral Nervous System as an Immune-Mediated Complication of Antitumor Therapy. Innovative Medicine of Kuban. 2026;11(1-1):3-11. (In Russ.)
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