Hypophysitis as a Manifestation of Neurotoxicity in the Treatment of Cancer
Abstract
Neurological toxicity is a rare but highly serious – and in some cases fatal – complication of cancer therapy. Hypophysitis is a manifestation of this spectrum of adverse effects, being not a classical complication. It is typically associated with the use of antiCTLA-4 agents. Magnetic resonance imaging (MRI) of the sellar region plays a key role in the diagnosis of this condition, enabling the detection of pituitary enlargement, structural alterations, and evaluation of disease dynamics during therapy.
About the Authors
E. Yu. Krivitskaya
Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1; Kuban State Medical University
Russian Federation
Russian Federation
Elena Yu. Krivitskaya, Radiologist X-ray Department; Assistant, Department of Radiation Diagnostics No. 2
Krasnodar
E. I. Zyablova
Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1; Kuban State Medical University
Russian Federation
Russian Federation
Elena I. Zyablova, Dr. Sci. (Med.), Associate Professor Head of the Department of Radiation Diagnostics No. 2; Head of the X-ray Department; Chief Freelance Radiologist of the Ministry of Health of the Krasnodar Region
167 1 Maya St., Krasnodar, 350086
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Review
For citations:
Krivitskaya E.Yu., Zyablova E.I. Hypophysitis as a Manifestation of Neurotoxicity in the Treatment of Cancer. Innovative Medicine of Kuban. 2026;11(1-1):37-41. (In Russ.)
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