Preview

Innovative Medicine of Kuban

Advanced search

HEREDITARY TROMBOPHILIA AND ISCHEMIC STROKE IN YOUNG ADULTS

Abstract

In this article the most widespread hereditary trombophilia in the setting of ischemic stroke etiology in young patients is considered. Own data on prevalence of various options of hereditary trombophilia in 188 patients who were treated in neurologic department for patients with acute disorders of cerebral blood circulation in Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1 are provided.

About the Authors

P. V. Kataev
Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, The Krasnodar Krai Ministry of Health
Russian Federation

Neurologist, neurological department for patients with ACVE

350086, Krasnodar, 167, 1st May str.



L. V. Timchenko
Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, The Krasnodar Krai Ministry of Health
Russian Federation

Neurologist, head of the neurological department for patients with ACVE



O. N. Zhadan
Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, The Krasnodar Krai Ministry of Health
Russian Federation

Neurologist, head of the neurorehabilitation department



D. K. Sichinava
Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, The Krasnodar Krai Ministry of Health
Russian Federation

Cand. of Sci. (Med.), neurologist, consulting and diagnostic clinic



References

1. Kissela B.M., Khoury J.C., Alwell K. et al. Age at stroke: temporal trends in stroke incidence in a large, biracial population. Neurology. 2012;79:1781-1787. DOI: 10.1212/WNL.0b013e318270401d. PMID: 23054237.

2. Kay W.P. Ng, Pei K. Loh, and Vijay K. Sharma. Role of Investigating Thrombophilic Disorders in Young Stroke. Stroke Research and Treatment. Vol. 2011 (2011). ID 670138. 9 p. doi:10.4061/2011/670138.

3. Guercini F., Acciarresi M., Agnelli G. et al. Cryptogenic stroke: time to determine aetiology. J Thromb Haemost. 2008;6(4):549-554. DOI: 10.1111/j.1538-7836.2008.02903.x. PMID: 18208534.

4. Palomeras S.E., Fossas F.P., Cano O.A.T. et al. Cryptogenic infarct. A follow-up period of 1 year study. Neurologia. 2009;24(5):304-308. PMID: 19642032.

5. Hart R.G., Diener H.C., Connolly S.J. Embolic strokes of undetermined source: support for a new clinical construct – authors’ reply. Lancet Neurol. 2014;13(10):967. DOI: 10.1016/S1474-4422(14)70197-8. PMID: 25231516.

6. Добрынина Л.А., Калашникова Л.А., Патрушева Н.Л. и др. Полиморфизм генов 5,10-метилен-тетрагилрофолатредуктазы, протромбина и V фак-тора свертывания крови у молодых больных с ишемическим инсультом. Клиническая медицина. 2012. №3. С. 37-40. [Dobrinina L.A., Kalashnikova L.A., Patrusheva N.L. i dr. Polimorfizm genov 5,10 - metilentetragilrofolatreduktazi, protrombina i V faktora svertivaniya krovi u molodih bolnih s ishemicheskim insultom.Klinicheskaya medicina. [Clinical Medicine]. 2012;3:37-40. (In Russ.)].

7. Пизова Н.В. Тромбофилии: генетические полиморфизмы и сосудистые катастрофы. М.: ИМА-ПРЕСС, 2013. С. 248. [Pizova N.V. Trombofilii geneticheskie polimorfizmi i sosudistie katastrofi. M.: IMA-PRESS, 2013.248 р. (In Russ.)].

8. Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thromb. Diath. Haemorgh. 1965;13:516-530. PMID: 14347873.

9. Воробьев А.И. Гиперкоагуляционный синдром в клинике внутренних болезней. Доклад на за-седании МГНОТ 12 ноября 2008 года. Московский доктор. Вестник Московского городского научно-го общества терапевтов. 2009;3(92):1,4-5. [Vorobev A.I. Giperkoagulyacionnii sindrom v klinike vnutrennih boleznei. Doklad na zasedanii MGNOT 12 noyabrya 2008 goda. Moskovskii doktor. Vestnik Moskovskogo gorodskogo nauchnogo obschestva terapevtov. [Bulletin of the Moscow City Scientific Society of Physicians]. 2009;3(92):1,4-5.(In Russ.)].

10. Salwa Khanr and Joseph D. Dickerman. Hereditary thrombophilia. Thrombosis Journal. 2006;4:15. DOI: 10.1186/1477-9560-4-15.

11. Dahlbäck B. Advances in understanding pathogenic mechanisms of thrombophilic disorders. Blood. 2008;112(1):19-27. DOI: 10.1182/blood-2008-01-077909. PMID: 18574041.

12. Martiskainen M., Pohjasvaara T., Mikkelsson J. et al. Fibrinogen gene promoter 455-A allele as a risk factor for lacunar stroke. Stroke. 2003;34:886-891. DOI: 10.1161/01.STR.0000060029.23872.55. PMID: 12637691.

13. Moster M. Coagulopathies and arterial stroke. Journal of Neuro-Ophthalmology. 2003;23(1):63–71. PMID: 12616091.

14. Aznar J., Mira Y., Vayá A. et al. Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke. Thromb Haemost. 2004;91(5):1031-1034. DOI: 10.1160/TH03-11-0690. PMID: 15116266.

15. Margaglione M., D’Andrea G., Giuliani N. et al. Inherited prothrombotic conditions and premature ischemic stroke: sex difference in the association with factor V Leiden. Arterioscler Thromb Vasc Biol. 1999;19:1751-1756. PMID: 10397694.

16. Пизова Н.В. Ишемический инсульт и наследственные тромбофилические состояния. Анналы клинической и экспериментальной неврологии. 2017;11(4):71-80. DOI: 10.18454/ACEN.2017.4.8 [Pizova N.V. Ishemicheskii insult i nasledstvennie trombofilicheskie sostoyaniya. Annali klinicheskoi i eksperimentalnoi nevrologii. [Annals of clinical and experimental neurology]. 2017;11(4):71-80. (In Russ.)]. DOI: 10.18454/ACEN.2017.4.8

17. Rosendaal F.R., Doggen C.J.M., Zivelin A. et al. Geographic distribution of the 20210G to A prothrombin variant. Thromb Haemost. 1998;79(4):706-8.

18. Pinotti M., Toso R., Girelli D. et al. Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies. Blood. 2000;95(11):3423-8.

19. Schwartz M.L., Pizzo S.V., Hill R.I. et al. Human factor XIII from plasma and platelets: molecular weight, subunit structures, proteolytic activation and cross-linking of fibrinigen and fibrin. J Biol Chem. 1973;248(4):1395-407.

20. Mosesson M.W. Dysfibrinogenemia and thrombosis. Semin Thromb Hemost.1999;(35)3:311–9.

21. Gohil R., Peck G., Sharma P. The genetics of venous thromboembolism. A meta-analysis involving approximately 120,000 cases and 180,000 controls». Thromb Haemost. 2009 Aug;102(2):360-70. PMID:19652888. DOI: 10.1160/TH09-01-0013.

22. Welch G., Loscalo J. Homocysteine and atherosclerosis. New Engl J Med.1998;338(15):1042-50.


Review

For citations:


Kataev P.V., Timchenko L.V., Zhadan O.N., Sichinava D.K. HEREDITARY TROMBOPHILIA AND ISCHEMIC STROKE IN YOUNG ADULTS. Innovative Medicine of Kuban. 2018;(3):11-15. (In Russ.)

Views: 473


ISSN 2541-9897 (Online)