Parathyroid hormone-related protein as predictor of urolithiasis disease development
https://doi.org/10.35401/2500-0268-2020-17-1-41-46
Abstract
Background. The present article studies a possible role of parathyroid hormone-related protein (PTHrP) in urolithiasis pathogenesis.
Aim. To consider PTHrP level as a predictor of the urolithiasis development.
Material and Methods. We presented an analysis of treatment in 79 patients with primary and recurrent nephrolithiasis that had underwent surgical treatment in the Uronephrological Center of Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, Krasnodar from 2017 to 2019. All observed patients were divided in two groups: patients with primary and recurrent nephrolithiasis. A group of 10 relatively healthy people was included in the study as well. All patients and conditionally healthy people had a test for blood parameters; in particular, the level of parathyroid hormone-related protein was assessed in order to compare the indicators in all three groups.
Conclusions. The PTHrP level was showed to be statistically significantly different in patients with urolithiasis from the group with relatively healthy people. Groups with primary and recurrent nephrolithiasis show not difference in the level of PTHrP. Further studies are necessary to consider this protein as one of the predictors of urolithiasis and study its role in the pathogenesis of nephrolithiasis.
About the Authors
A. A. Budanov
Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1
Russian Federation
Russian Federation
Artem A. Budanov, Urologist of Urology Department; Postgraduate Student of Urology Department
4, Sedina str., Krasnodar, 350063
V. L. Medvedev
Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1
Russian Federation
Russian Federation
Vladimir L. Medvedev, Dr. of Sci. (Med.), Professor, Deputy Chief Doctor on Urology; Head of Regional Uronephrologic Center, Chief External Urologist of Health Care Ministry of Krasnodar Region, Head of Urology Department
A. N. Kurzanov
Kuban State Medical University
Russian Federation
Russian Federation
Anatoly N. Kurzanov, Dr. of Sci. (Med.), Professor, Department of Clinical Pharmacology and Functional Diagnostics, Department of Fundamental and Clinical Biochemistry
A. A. Basov
Kuban State Medical University
Russian Federation
Russian Federation
Aeksandr A. Basov, Professor of Fundamental and Clinical Biochemistry
G. A. Palaguta
Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1
Russian Federation
Russian Federation
Georgy A. Palaguta, Urologist of Urology Department; Teaching Assistant of Urology Department
T. V. Rusinova
Kuban State Medical University
Russian Federation
Russian Federation
Tatyana V. Rusinova, Cand. of Sci. (Biol.), Researcher, Сentral Research Laboratory
References
1. Sorokin I, Mamoulakis Ch, Miyazawa К, Rodgers А, Talati J, Lotan Ya. Epidemiology of stone disease across the world. World J Urol. 2017;35(9):1301-20. DOI: 10.1007/s00345-017-2008-6
2. Gottlieb M, Long B, Koyfman A. The evaluation and management of urolithiasis in the ED: a review of the literature. Am J Emerg Med. 2018;36(4):699-706. DOI: 10.1016/j.ajem.2018.01.003
3. Apolikhin OI, Sivkov AV, Komarov VA, Prosyannikov MJu, et al. Incidence of urolithiasis in the Russian Federation (2005-2016). Eksperimentalnaya i klinicheskaya urologiya. 2018;4:4-14. (In Russ.).
4. Sharma S, Rastogi A, Bhadada SK, et al. Prevalence and predictors of primary hyperparathyroidism among patients with urolithiasis. Endocrine Practice. 2017;23(11):1311-5. DOI: 10.4158/EP171759.OR
5. Perotokina EV, Mokrysheva NG. Nephrolithiasis in primary hyperparathyroidism, a contemporary look. Ozhirenie i metabolizm. 2014;11(3):3-8. (In Russ.). DOI: 10.14341/omet201433-8
6. Kurzanov AN, Bykov IM, Ledvanov MYu. Parathyroid hormone-like protein – modern views on structure, biochemical characteristics and physiological role in organism. Sovremennye problemy nauki i obrazovaniya. 2016;6. URL: http://science-education.ru/ru/article/view?id=25543 (In Russ.).
7. Kurzanov AN, Ledvanov MYu, Bykov IM, et al. Parathormone-related protein. Monograph. Мoscow: Publishing House of the Natural Science Academy, 2018. P. 77-78. (In Russ.).
8. Deligiorgi MV, Panayiotidis MI, Travails DT. Parathyroid hormone related protein (PTHrP)-mediated hypercalcemia in malignancy associated with anti-PD-1 immune checkpoint inhibitor treatment and related inflammatory reactions. Int Immunopharmacol. 2019;77:105942. DOI: 10.1016/j.intimp.2019.105942
9. Medvedev VL, Strygina EA, Kurzanov AN. Parathyroid hormone-related protein and prostate cancer. Kubanskiy naychny meditsinskiy vestnik. 2017;1(162):145-54. (In Russ.).
10. Lai NK, Martinez D. Physiological roles of parathyroid hormone-related protein. Acta Biomed. 2019;23:90(4):510-6. DOI: 10.23750/abm.v90i4.7715
11. Medvedev VL, Ledvanov MYu, Kurzanov AN, Bykov IM. The role of parathormon-related protein in the development, functioning and pathology of urinary and reproductive systems. Monograph. Moscow: Publishing House of the Natural Science Academy, 2019. P. 14-16. (In Russ.).
12. Nekrasov SD. Mathematical methods in psychology (MS Excel). 3rd ed., corrected and completed. Krasnodar: Kubansky gos. universitet, 2014. 147 р. URL: http://docspace.kubsu.ru/docspace/handle/1/295 (In Russ.).
Review
For citations:
Budanov A.A., Medvedev V.L., Kurzanov A.N., Basov A.A., Palaguta G.A., Rusinova T.V. Parathyroid hormone-related protein as predictor of urolithiasis disease development. Innovative Medicine of Kuban. 2020;(1):41-46. (In Russ.) https://doi.org/10.35401/2500-0268-2020-17-1-41-46
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