Intraoperative radiation therapy in the treatment of breast cancer. From the past to the future
https://doi.org/10.35401/2500-0268-2022-25-1-77-82
Abstract
This article discusses the experience of using intraoperative radiation therapy in the treatment of patients with breast cancer, as well as the prospects for the development of this area in terms of benefits (improved therapy effect, reduced severity of side effects, no effect on adjacent organs) and risks (the possibility of local recurrence) for patients.
About the Authors
I. S. Chumachenko
Clinical Oncology Dispensary no. 1
Russian Federation
Russian Federation
Igor S. Chumachenko, Oncologist of the Oncology Department no. 8
146, Dimitrova str., Krasnodar, 350040
R. A. Murashko
Clinical Oncology Dispensary no. 1
Russian Federation
Russian Federation
Roman A. Murashko, Cand. Sci. (Med.), Chief Physician
Krasnodar
A. A. Keshabyan
Clinical Oncology Dispensary no. 1
Russian Federation
Russian Federation
Arthur A. Keshabyan, Cand. Sci. (Med.), Head of the Oncology Department no. 8
Krasnodar
References
1. Forman D, Bray F, Brewster DH, et al. Cancer Incidence in Five Continents: Inclusion criteria, highlights from Volume X and the global status of cancer registration. Int J Cancer. 2015;137(9):2060–2071. PMID: 26135522. http://doi.org/10.1002/ijc.29670
2. Merabishvili VM. Cancer Control in St. Petersburg (operative report for 2011–2012, precise elaboration of registry’s database by international standards). Populationbased Cancer Registry (IACR no. 221) Sci. publ. no. 18. Eds. Kolabutina VM, Belyaeva AM. Saint Petersburg: LLC “Publishing and printing company ‘COSTA’; 2013;364. (In Russ.).
3. Chernaya АV, Kanaev SV, Novikov SN, et al. Mammography and mammoscintigraphy with 99m TC-MIBI in the detection of multicentric breast cancer. Questions of Oncology. 2017;63(2):274–280. (In Russ.). https://doi.org/10.37469/0507-3758-2017-63-6-876-881
4. Polgar C, Fodor J, Major T, et al. Breast-conserving therapy with partial or whole breast irradiation: ten-year results of the Budapest randomized trial. Radiother Oncol. 2013;108(2):197–202. PMID: 23742961. https://doi.org/10.1016/j.radonc.2013.05.008
5. Polgar C, Ott OJ, Hildebrandt G, et al. Late side effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast conserving surgery for low-risk invasive and in situ carcinoma of the female breast: 5-year results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2017;18(2):259–268. PMID: 28094198. https://doi.org/10.1016/S1470-2045(17)30011-6
6. Chumachenko IS, Murashko RA, Keshabyan AA, et al. Results of organ-preserving treatment of breast cancer using intraoperative radial therapy. Tumors of female reproductive system. 2021;17(3):16–23. (In Russ.). https://doi.org/10.17650/1994-4098-2021-17-3-16-23
7. Veronesi U, Luini A, Vecchio M, et al. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med. 1993;328(22):1587–1591. PMID: 8387637. https://doi.org/10.1056/NEJM199306033282202
8. Fisher ER, Anderson S, Redmond C, et al. Ipsilateral breast tumor recurrence and survival following lumpectomy and irradiation: pathological findings from NSABP protocol B-06. Semin Surg Oncol. 1992;8(3):161–166. PMID: 1496227.
9. Holland R, Veling SH, Mravunac M, et al. Histologic multifocality of Tis, T1–2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer. 1985;56(5):979–990. PMID: 2990668. https://doi.org/10.1002/1097-0142(19850901)56:5%3C979::aid-cncr2820560502%3E3.0.co;2-n
10. Bryantseva ZV, Akulova IA, Novikov SN, et al. High Dose Rate Brachytherapy in Treatment of Breast Cancer Patients. Journal of oncology: diagnostic radiology and radiotherapy. 2019;2(4):26–34. (In Russ.). https://doi.org/10.37174/2587-7593-2019-2-4-26-34
11. Bartelink H, Horiot JC, Poortmans PM, et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881–10882 trial. J Clin Oncol. 2007;25(22):3259–3265. PMID: 17577015. https://doi.org/10.1200/jco.2007.11.4991
12. Faverly DR, Hendriks JH, Holland R. Breast carcinomas of limited extent: frequency, radiologic-pathologic characteristics, and surgical margin requirements. Cancer. 2001;91:647–659. PMID: 11241230. https://doi.org/10.1002/1097-0142(20010215)91:4<647::aid-cncr1053>3.0.co;2-z
13. Veronesi U, Orecchia R, Maisonneuve P, et al. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomized controlled equivalence trial. Lancet Oncol. 2013;14:1269–1277. PMID: 24225155. https://doi.org/10.1016/S1470-2045(13)70497-2
14. Zakharova NA, Semiglazov VF, Duffy SW. Screening of the mammary gland cancer. Мoscow: GEOTAR-Media; 2011;176. (In Russ.).
15. Semiglazov VF. Screening for early diagnostics of breast cancer. Medical almanac. 2008;4:63–65. (In Russ.).
16. Semiglazov VF, Semiglazov VV. Screening of mammary gland cancer. Practical Oncology. 2010;11(2):60–65. (In Russ.).
17. Willich N. Technical and methodical developments of radiation oncology from a physician’s point of view. Strahlenther Onkol. 2012;188(3):253–262. PMID: 22895626. (In German). https://doi.org/10.1007/s00066-012-0190-4
18. Skoropad VYu, Berdov BA. The history and modern state of clinical usage of the intraoperative radiation therapy in patients with stomach cancer. Russian Journal of Oncology. 1998;5:55–58. (In Russ.).
19. Kulcenty K, Piotrowski I, Wróblewska JP, et al. The Composition of Surgical Wound Fluids from Breast Cancer Patients is Affected by Intraoperative Radiotherapy Treatment and Depends on the Molecular Subtype of Breast Cancer. Cancers. 2020;12(1):124–132. PMID: 31861498. PMCID: PMC7016654. https://doi.org/10.3390/cancers12010011
20. Krengli M, Sedlmayer F, Calvo FA, et al. ISIORT pooled analysis 2013 update: clinical and technical characteristics of intraoperative radiotherapy. Transl Cancer Res. 2014;3(1):48–58. http://doi.org/10.3978/j.issn.2218-676X.2014.01.02
21. Kusters M, Valentini V, Calvo FA, et al. Results of European pooled analyses of IORT-containing multimodality treatment for locally advanced rectal cancer: adjuvant chemotherapy prevents local recurrence rather than distant metastases. Ann Oncol. 2010;21:1279–1284. https://doi.org/10.1093/annonc/mdp501
22. Valentini V, Calvo F, Reni M, et al. Intra-operative radiotherapy (IORT) in pancreatic cancer: joint analysis of the ISIORT-Europe experience. Radiother Oncol. 2009;9:54–59. PMID: 18762346. https://doi.org/10.1016/j.radonc.2008.07.020
23. Comas С, Prio A. Irradiation roentgen preventive intraabdominal, après l’intervention chirurgicale dans un cas de cancer de l’uterus. Congres International d’Electrologie, Imprenta Francesca Badia, Barcelona 1906. (In French).
24. Abe M, Fukuda M, Yamano K, et al. Intra-Operative Irradiation in Abdominal and Cerebral Tumours. Acta Radiol Ther Phys Biol. 1971;10(4):408–416. PMID: 4107080. https://doi.org/10.3109/02841867109130786
25. Vaidya JS, Wenz F, Bulsara M, et al. Risk-adapted targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomized trial. Lancet. 2014;383(9917):603–613. PMID: 24224997. http://doi.org/10.1016/S0140-6736(13)61950-9
26. Chirag Sh. Intraoperative Radiation Therapy for Breast Cancer: Are We There Yet? Ann Surg Oncol. 2021;28:20–22. PMID: 33206264. https://doi.org/10.1245/s10434-020-09356-y
27. Harris E, Small WJr. Intraoperative Radiotherapy for Breast Cancer. Front Oncology. 2017;22:310–317. https://doi.org/10.3389/fonc.2017.00317
28. Elizabeth O, Martin CT, Bindu VM, et al. Outcomes with intraoperative radiation therapy for early-stage breast cancer. Breast J. 2020;26(3):454–457. PMID: 31562688. https://doi.org/10.1111/tbj.13574
29. Sedlmayer F, Reitsamer R, Wenz F, et al. Intraoperative radiotherapy (IORT) as boost in breast cancer. Radiation Oncology. 2017;12(1):23–35. PMID: 28103903. PMCID: PMC5244574. https://dx.doi.org/10.1186%2Fs13014-016-0749-9
30. Pasechnikova EA, Bodnya VN, Kadomtsev DV, et al. The role of intraoperative radiation therapy in the complex treatment of breast cancer: current state of the problem. Modern problems of sci ence and education. 2020;1. (In Russ.). https://doi.org/10.17513/spno.29491
31. König L, Lang K, Heil J, et al. Acute Toxicity and Early Oncological Outcomes After Intraoperative Electron Radiotherapy (IOERT) as Boost Followed by Whole Breast Irradiation in 157 Early Stage Breast Cancer Patients – First Clinical Results From a Single Center. Frontiers in Oncology. 2019;9:384–394. https://doi.org/10.3389/fonc.2019.00384
32. Jacobs DH, Horeweg N, Straver M, et al. Health-related quality of life of early-stage breast cancer patients after different radiotherapy regimes. Breast Cancer Res Treat. 2021;189(2):387–398. PMID: 34216316. PMCID: PMC8357747. https://dx.doi.org/10.1007%2Fs10549-021-06314-4
33. Grinev IA. Intraoperative radiation therapy in breast can cer patients after neoadjuvant drug treatment. Dissertation. Saint Petersburg; 2017. (In Russ.).
34. Trofimova OP, Tkachev SI, Khailenko VA, et al. Radiation therapy in the organ-conserving treatment of patients with early breast cancer – what has changed? Oncology. 2013;2:53–56. (In Russ.).
35. Keshtgar MR, Vaidya JS, Tobias JS, et al. Targeted intraoperative radiotherapy for breast cancer in patients in whom external beam radiation is not possible. Int J Radiat Oncol Biol Phys. 2011;80(1):31–38. PMID: 20646864. https://doi.org/10.1016/j.ijrobp.2010.01.045
36. Kaiser J, Reitsamer R, Kopp P, et al. Intraoperative Electron Radiotherapy (IOERT) in the Treatment of Primary Breast Cancer. Breast Care (Basel). 2018;13(3):162–167. PMID: 30069175. PMCID: PMC6062668. https://doi.org/10.1159/000489637
37. Ter-Ovanesov MD, Kukosh MYu. Intraoperative radiation therapy: yesterday, today, future. Medical alphabet. 2017;3(35):23–28. (In Russ.).
38. Kanaev SV, Novikov SN, Bryantsev ZhV, et al. Comparison between high dose rate brachytherapy and electron beam radiation in patients who received additional radiation to the tumor bed of removed breast tumor. Questions of oncology. 2018;64(3):303–309. (In Russ.). https://doi.org/10.37469/0507-3758-2018-64-3-303-309
39. Akulova IA, Novikov SN, Tseluyko AI, et al. Comparison of cosmetic results after treatment in women with breast cancer who received additional radiation to the tumor bed. Tumors of female reproductive system. 2020;16(3):57–66. (In Russ.). http://doi.org/10.17650/1994-4098-2020-16-3-56-66
Review
For citations:
Chumachenko I.S., Murashko R.A., Keshabyan A.A. Intraoperative radiation therapy in the treatment of breast cancer. From the past to the future. Innovative Medicine of Kuban. 2022;(1):77-82. (In Russ.) https://doi.org/10.35401/2500-0268-2022-25-1-77-82
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