Atypical hemolytic-uremic syndrome in children
https://doi.org/10.35401/2541-9897-2022-25-4-62-67
Abstract
Background: Atypical hemolytic-uremic syndrome (aHUS) is a rare progressive form of systemic thrombotic microangiopathy (TMA), which develops due to uncontrolled activation of the alternative pathway of the complement system and is characterized by a predominant lesion of the vessels of the renal microcirculatory bed.
Clinical cases description: The article describes two clinical cases of aHUS, which demonstrate the difficulties of differential diagnosis of typical and atypical HUS at the initial stages of the disease.
Conclusion: Given the lack of clear laboratory criteria of aHUS, it is necessary to carry out a complex and consistent differential diagnosis of various TMA options, the exclusion of which makes it possible to make a correct diagnosis more accurately.
About the Authors
A. V. Burlutskaya
Kuban State Medical University
Russian Federation
Russian Federation
Alla V. Burlutskaya, Dr. Sci. (Med.), Head of the Pediatrics Department no. 2
4, M. Sedina str., Krasnodar, 350063
A. V. Statova
Kuban State Medical University
Russian Federation
Russian Federation
Anastasia V. Statova, Cand. Sci. (Med.), Associate Professor, Pediatrics Department no. 2
4, M. Sedina str., Krasnodar, 350063
D. V. Ustyuzhaninа
Kuban State Medical University
Russian Federation
Russian Federation
Diana V. Ustyuzhaninа, Resident, Pediatrics Department no. 2
4, M. Sedina str., Krasnodar, 350063
Yu. V. Pisotskaya
Kuban State Medical University
Russian Federation
Russian Federation
Yulia V. Pisotskaya, Resident, Pediatrics Department no. 2
4, M. Sedina str., Krasnodar, 350063
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Review
For citations:
Burlutskaya A.V., Statova A.V., Ustyuzhaninа D.V., Pisotskaya Yu.V. Atypical hemolytic-uremic syndrome in children. Innovative Medicine of Kuban. 2022;(4):62-67. (In Russ.) https://doi.org/10.35401/2541-9897-2022-25-4-62-67
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