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Comparison of Cardioprotective Effects of Dapagliflozin and Trimetazidine in the Model of Doxorubicin-Cyclophosphamide Cardiotoxicity

https://doi.org/10.35401/2541-9897-2023-8-4-6-14

Abstract

Background: Data published by task groups of the Ministry of Health of the Russian Federation, the European Society of Cardiology, and other medical associations and institutions show that chemotherapy-induced cardiomyopathy is still a challenging issue that requires further research.

Objective: To compare the cardioprotective potential of trimetazidine and dapagliflozin in a rat model of doxorubicin-cyclophospha-mide cardiomyopathy.

Materials and methods: Our randomized in vivo experimental study included 80 Wistar female rats. Doxorubicin and cyclophosphamide were administered at a dose of 15 mg/kg and 150 mg/kg, respectively. Trimetazidine (42 mg/kg) and dapagliflozin (14 mg/kg) were additionally administered to groups 3 and 4, respectively. The total duration of the experiment was 14 days.

Results: Doxorubicin+cyclophosphamide mode of chemotherapy induces the development of toxic-ischemic cardiomyopathy. The trimetazidine and dapagliflozin administration was accompanied by stabilization of cardiovascular parameters. Comparison of both drugs’ cardioprotective properties revealed a clear advantage of dapagliflozin over trimetazidine, especially in terms of such an important indicator as N-terminal pro-B-type natriuretic peptide.

Conclusions: Further research aimed at exploring the cardioprotective potential of dapagliflozin against cardiovascular complications of chemotherapy is justified from a pathogenetic point of view.

About the Authors

A. A. Avagimyan
Yerevan State Medical University after M. Heratsi
Armenia

Ashot A. Avagimyan, Cand. Sci. (Med.), Assistant Professor at the Department of Pathological Anatomy and Clinical Morphology

Yerevan

 


A. I. Trofimenko
Kuban State Medical University
Russian Federation

Artem I. Trofimenko, Cand. Sci. (Med.), Associate Professor at the Pathological Physiology Department

Krasnodar



M. Sheibani
Iran University of Medical Sciences
Islamic Republic of Iran

Mohammad Sheibani, PhD, Assistant Professor at the Department of Pharmacology, School of Medicine

Tehran



L. V. Kakturskiy
Russian Scientific Center of Surgery named after Academician B.V. Petrovsky
Russian Federation

Lev V. Kakturskiy, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Scientific Director of the Research Institute of Human Morphology named after Academician A.P. Avtsyn

Moscow

 


O. I. Urazova
Siberian State Medical University
Russian Federation

Olga I. Urazova, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Pathophysiology Department

Tomsk



G. A. Navasardyan
Yerevan State Medical University after M. Heratsi
Armenia

Grizelda A. Navasardyan, Cand. Sci. (Med.), Professor at the Department of Pathophysiology

Yerevan



Z. T. Jndoyan
Yerevan State Medical University after M. Heratsi
Armenia

Zinaida T. Jndoyan, Dr. Sci. (Med.), Professor, Head of the Internal Disease Propedeutics Department

Yerevan

 


N. V. Sulashvili
Tbilisi State Medical University
Georgia

Nodar V. Sulashvili, PhD, Associate Professor, Guest Lec- turer at the Practical Center for Scientific Skills

Tbilisi



L. I. Gabunia
Tbilisi State Medical University
Georgia

Luiza I. Gabunia, Dr. Sci. (Med.), Director of the Practical Center for Scientific Skills

Tbilisi

 


N. S. Gorgaslidze
Tbilisi State Medical University
Georgia

Nana S. Gorgaslidze, PhD, Professor, Head of the Department of Social and Clinical Pharmacy

Tbilisi

 


F. M. Khamidova
Samarkand State Medical University
Uzbekistan

Farida M. Khamidova, Cand. Sci. (Med.), Associate Professor, Head of the Pathological Anatomy Department

Samarkand



L. A. Martemyanova
Gomel State Medical University
Belarus

Ludmila A. Martemyanova, Cand. Sci. (Med.), Associate Professor, Head of the Pathological Anatomy Department

Gomel



N. V. Pogosova
National Medical Research Centre of Cardiology named after Academician E.I. Chazov
Russian Federation

Nana V. Pogosova, Dr. Sci. (Med.), Professor, Deputy General Director for Science and Preventive Cardiology

Moscow



N. Sarrafzadegan
Isfahan University of Medical Science
Islamic Republic of Iran

Nizal Sarrafzadegan, PhD, Distinguished Professor, Director of the Isfahan Cardiovascular Research Institute

Isfahan



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Review

For citations:


Avagimyan A.A., Trofimenko A.I., Sheibani M., Kakturskiy L.V., Urazova O.I., Navasardyan G.A., Jndoyan Z.T., Sulashvili N.V., Gabunia L.I., Gorgaslidze N.S., Khamidova F.M., Martemyanova L.A., Pogosova N.V., Sarrafzadegan N. Comparison of Cardioprotective Effects of Dapagliflozin and Trimetazidine in the Model of Doxorubicin-Cyclophosphamide Cardiotoxicity. Innovative Medicine of Kuban. 2023;(4):6-14. (In Russ.) https://doi.org/10.35401/2541-9897-2023-8-4-6-14

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ISSN 2541-9897 (Online)