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Biomarkers of Progressive Fibrosing Interstitial Lung Diseases

https://doi.org/10.35401/2541-9897-2023-8-4-126-133

Abstract

Despite adequate therapy, interstitial lung diseases (ILD) can cause progressive scarring of lung tissue. This type of ILD is known as progressive fibrosing ILD (PF­-ILD). The challenge in diagnosing PF-­ILD lies in the lack of uniformly accepted criteria for a progressive fibrosing phenotype. Most authors use criteria based on clinical features and assessment of functional imaging and radiological findings over time. However, forced vital capacity (FVC) measurement is limited by its variability, and the follow­up lasts 1­2 years. The above diagnostic challenges prevent from prescribing early adequate therapy in patients with progressive ILD, indicting the need to search for new biomarkers of the progressive fibrosing phenotype. We review the most studied and informative biomarkers of fibrosis progression in patients with ILD.

About the Authors

E. V. Bolotova
Kuban State Medical University
Russian Federation

Elena V. Bolotova, Dr. Sci. (Med.), Professor at Therapy Department No. 1, Professor at the Pulmonology Department, Faculty of Continuing Professional Development and Retraining

ulitsa M. Sedina 4, Krasnodar, 350063



Yu. G. Yurkova
Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1
Russian Federation

Yulia G. Yurkova, Postgraduate Student, Pulmonology Department, Faculty of Continuing Professional Development and Retraining; Pulmonologist

Krasnodar



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Review

For citations:


Bolotova E.V., Yurkova Yu.G. Biomarkers of Progressive Fibrosing Interstitial Lung Diseases. Innovative Medicine of Kuban. 2023;(4):126-133. (In Russ.) https://doi.org/10.35401/2541-9897-2023-8-4-126-133

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