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Normally Developing Pregnancy and Hydatidiform Mole: A Case Report

https://doi.org/10.35401/2541-9897-2024-9-3-84-90

Abstract

Introduction: Hydatidiform mole with a normally developing fetus is a rare case associated with an increased risk of bleeding, preterm birth, preeclampsia, congenital anomalies, and intrauterine fetal death.

Case report: We report a case of a twin pregnancy with a hydatidiform mole and a normal fetus. The pregnancy was conceived via in vitro fertilization. The complete hydatidiform mole was diagnosed during the first screening. We extended the pregnancy until 38 weeks’ gestation. Thanks to the control of beta-human chorionic gonadotropin levels and dynamic ultrasound monitoring, the woman successfully gave birth. 

About the Authors

A. V. Peredvigina
National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov
Russian Federation

Anastasiia V. Peredvigina, Cand. Sci. (Med.), Ultrasonographer, Ultrasound and Functional Diagnostics Unit, Diagnostic Imaging Division

ulitsa Akademika Oparina 4, Moscow, 117198



M. V. Semenova
Izhevsk State Medical Academy
Russian Federation

Margarita V. Semenova, Cand. Sci. (Med.), Associate Professor, Head of the Obstetrics and Gynecology Department



A. S. Talabadze
Izhevsk State Medical Academy
Russian Federation

Anna S. Talabadze, Obstetrician-Gynecologist, Assistant Professor at the Obstetrics and Gynecology Department



M. V. Serova
First Republican Clinical Hospital
Russian Federation

Marina V. Serova, Head of the Pregnancy Pathology Unit,
Perinatal Center



E. P. Sakhabutdinova
First Republican Clinical Hospital
Russian Federation

Elena P. Sakhabutdinova, First Deputy Chief Physician



I. V. Fedorova
Republican Pathoanatomical Bureau of the Ministry of Health of the Udmurt Republic
Russian Federation

Irina V. Fedorova, Pathologist



A. N. Sencha
National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov; Pirogov Russian National Research Medical University
Russian Federation

Alexander N. Sencha, Dr. Sci. (Med.), Head of the Diagnostic Imaging Division; Professor at the Diagnostic Ultrasound Department



References

1. Clinical Guidelines – Trophoblastic Neoplasms – 2020-2021- 2022 (January 31, 2023) – Approved by the Ministry of Health of the Russian Federation. Accessed February 10, 2024. (In Russ.). https://disuria.ru/_ld/13/1351_kr20C58MZ.pdf

2. Altieri A, Franceschi S, Ferlay J, Smith J, La Vecchia C. Epidemiology and aetiology of gestational trophoblastic diseases. Lancet Oncol. 2003;4(11):670–678. PMID: 14602247. https://doi.org/10.1016/s1470-2045(03)01245-2

3. Ngan HYS, Seckl MJ, Berkowitz RS, et al. Diagnosis and management of gestational trophoblastic disease: 2021 update. Int J Gynaecol Obstet. 2021;155 Suppl 1(Suppl 1):86–93. PMID: 34669197. PMCID: PMC9298230. https://doi.org/10.1002/ijgo.13877

4. Ozalp SS, Yalcin OT, Tanir HM. Hydatidiform mole at extreme ages of reproductive life in a developing country from 1932 to 2000. Eur J Gynaecol Oncol. 2002;23(4):361–362. PMID: 12214746.

5. Fisher RA, Maher GJ. Genetics of gestational trophoblastic disease. Best Pract Res Clin Obstet Gynaecol. 2021;74:29–41. PMID: 33685819. https://doi.org/10.1016/j.bpobgyn.2021.01.004

6. Kaur B, Short D, Fisher RA, Savage PM, Seckl MJ, Sebire NJ. Atypical placental site nodule (APSN) and association with malignant gestational trophoblastic disease; a clinicopathologic study of 21 cases. Int JGynecol Pathol. 2015;34(2):152–158. PMID: 25675185. https://doi.org/10.1097/PGP.0000000000000128

7. Lurain JR. Hydatidiform mole: recognition and management. Contemporary OB/GYN Journal. 2019;64(03).

8. Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531–539. PMID: 20728069. https://doi.org/10.1016/j.ajog.2010.06.073

9. Sugrue R, Foley O, Elias KM, et al. Outcomes of minimally invasive versus open abdominal hysterectomy in patients with gestational trophoblastic disease. Gynecol Oncol. 2021;160(2):445–449. PMID: 33272644. https://doi.org/10.1016/j.ygyno.2020.11.022

10. Gül T, Yilmaztürk A, Erden AC. A review of trophoblastic diseases at the medical school of Dicle University. Eur J Obstet Gynecol Reprod Biol. 1997;74(1):37–40. PMID: 9243199. https://doi.org/10.1016/s0301-2115(97)00071-7

11. Yuk JS, Baek JC, Park JE, Jo HC, Park JK, Cho IA. Incidence of gestational trophoblastic disease in South Korea: a longitudinal, population-based study. PeerJ. 2019;7:e6490. PMID: 30809458. PMCID: PMC6387577. https://doi.org/10.7717/peerj.6490

12. Seckl MJ, Sebire NJ, Berkowitz RS. Gestational trophoblastic disease. Lancet. 2010;376(9742):717–729. PMID: 20673583. https://doi.org/10.1016/S0140-6736(10)60280-2

13. Piątek S, Szczęsny N, Szymusik I, et al. Fertility-sparing treatment in gestational choriocarcinoma: evaluating oncological and obstetrical outcomes in young patients. Med Sci Monit. 2023;29:e942078. PMID: 37957930. PMCID: PMC10656781. https://doi.org/10.12659/MSM.942078

14. Kirk E, Papageorghiou AT, Condous G, Bottomley C, Bourne T. The accuracy of first trimester ultrasound in the diagnosis of hydatidiform mole. Ultrasound Obstet Gynecol. 2007;29(1):70– 75. PMID: 17201012. https://doi.org/10.1002/uog.3875

15. Li L, An CY. Impact of ultrasound in diagnosis of hydatidiform mole in early pregnancy: a protocol of systematic review. Medicine (Baltimore). 2020;99(41):e22268. PMID: 33031268. PMCID: PMC10545258. https://doi.org/10.1097/MD.0000000000022268

16. Jauniaux E, Memtsa M, Johns J, Ross JA, Jurkovic D. New insights in the pathophysiology of complete hydatidiform mole. Placenta. 2018;62:28–33. PMID: 29405964. https://doi.org/10.1016/j.placenta.2017.12.008

17. Lin M, Chen J, Liao B, He Z, Lin S, Luo Y. When a vesicular placenta meets a live fetus: case report of twin pregnancy with a partial hydatidiform mole. BMC Pregnancy Childbirth. 2021;21(1):694. PMID: 34645420. PMCID: PMC8513365. https://doi.org/10.1186/s12884-021-04160-2

18. Shazly SA, Ali MK, Abdel Badee AY, Alsokkary AB, Khodary MM, Mostafa NA. Twin pregnancy with complete hydatidiform mole and coexisting fetus following ovulation induction with a non-prescribed clomiphene citrate regimen: a case report. J Med Case Rep. 2012;6:95. PMID: 22472309. PMCID: PMC3348033. https://doi.org/10.1186/1752-1947-6-95

19. Gajewska M, Zygula A, Wielgos M, Szewczyk G. Twin pregnancy with a partial hydatidiform mole and a coexistent live fetus. Diagnostic and therapeutic dilemmas. A case report and the review of literature. Ginekol Pol. 2020;91(10):589–594. PMID: 33184826. https://doi.org/10.5603/GP.a2020.0109

20. Dobrokhotova IE, Arakelov SE, Danielyan SZ, et al. Hydatidiform mole: a clinical case of pregnancy. Gynecology. 2019;21(2):28– 33. (In Russ.). https://doi.org/10.26442/20795696.2019.2.190347

21. Voloshchuk IN, Barinova IV, Kondrikov NI, Barto RA. Twin pregnancy with complete hydatidiform mole. Arkhiv patologii. 2017;79(5):43–48. (In Russ.). https://doi.org/10.17116/patol201779543-48

22. Suksai M, Suwanrath C, Kor-Anantakul O, et al. Complete hydatidiform mole with co-existing fetus: predictors of live birth. Eur J Obstet Gyneco Reprod Biol. 2017;212:1–8. PMID: 28301807. https://doi.org/10.1016/j.ejogrb.2017.03.013

23. Rohilla M, Singh P, Kaur J, Jain V, Gupta N, Prasad GR. Individualistic approach to the management of complete hydatidiform mole with coexisting live fetus. Eur J Obstet Gynecol Reprod Biol. 2015;191:39–42. PMID: 26070126. https://doi.org/10.1016/j.ejogrb.2015.05.017


Review

For citations:


Peredvigina A.V., Semenova M.V., Talabadze A.S., Serova M.V., Sakhabutdinova E.P., Fedorova I.V., Sencha A.N. Normally Developing Pregnancy and Hydatidiform Mole: A Case Report. Innovative Medicine of Kuban. 2024;(3):84-90. (In Russ.) https://doi.org/10.35401/2541-9897-2024-9-3-84-90

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ISSN 2541-9897 (Online)