A Systematic Literature Review on the Use of Artificial Intelligence in Medical Imaging in the Diagnosis of Oncologic Pathology
Abstract
Timely detection of malignant neoplasms, competent patient referral, and determination of an optimal treatment strategy remain among the most relevant issues of modern oncology. An analysis of international and domestic literature yielded the following statistics: in 2022, approximately 20 million new cancer cases and 9.7 million cancer-related deaths were recorded worldwide. In Russia, over 4.4 million patients are currently being oncological follow-up, with recent years showing a 10.5% increase in the proportion of patients observed for more than five years. A promising approach to improving the quality of tumor diagnostics is the implementation of artificial intelligence (AI) in medical imaging. One of the principal challenges in the development and training of neural network models is the acquisition of large and diverse imaging datasets, including CT series, MRI scans, and ultrasound images. The manual annotation of anatomical landmarks required to train neural networks for accurate recognition of human anatomical structures is an extremely labor-intensive but essential step in the creation of AI systems. This review analyzed recent studies by domestic and international researchers on the implementation and application of artificial intelligence (AI) in medical imaging for the diagnosis of malignant neoplasms. Studies were selected based on the following inclusion criteria: publications from 2020 to 2025, full-text literature reviews, systematic reviews, meta-analyses, original articles, and randomized controlled trials published in peer-reviewed scientific journals. Duplicates, conference abstracts, and studies lacking full text or not meeting the inclusion criteria were excluded. A total of 36 sources were included in the analysis. The review of both international and domestic literature demonstrated that AI-based systems in radiologic diagnostics of malignant neoplasms have significant potential for routine clinical use, particularly in enhancing the quality of differential diagnosis between benign and malignant lesions. Key advantages include the automation and standardization of quality control for radiographic and ultrasound images according to predefined anatomical scanning planes, as well as the ability to perform biometric measurements and detect pathognomonic features.
About the Authors
A. V. PomortsevRussian Federation
Alexey V. Pomortsev, Dr. Sci. (Med.), Professor, Head of Radiology Department No. 1
4 Mitrofana Sedina St., Krasnodar, 350063
J. Yu. Dyachenko
Russian Federation
Julia Yu. Dyachenko, Cand. Sci. (Med.), Associate Professor, Radiology Department No. 1, Faculty of Postgraduate Education and Professional Development
Krasnodar
M. A. Matosyan
Russian Federation
Mariam A. Matosyan, Assistant Professor, Radiology Department No. 1
Krasnodar
E. A. Arutyunyan
Russian Federation
Ekaterina A. Arutyunyan, Senior Laboratory Assistant, Radiology Department No. 1
Krasnodar
L. A. Khagurova
Russian Federation
Lyubov A. Khagurova, Laboratory Assistant, Radiology Department No. 1
Krasnodar
A. S. Novikova
Russian Federation
Anastasia S. Novikova, Laboratory Assistant, Radiology Department No. 1
Krasnodar
V. R. Nikitina
Russian Federation
Veronika R. Nikitina, 5th-year Student, Faculty of Pediatrics
Krasnodar
A. N. Katrich
Russian Federation
Alexey N. Katrich, Dr. Sci. (Med.), Head of the Ultrasound Diagnostics Department; Associate Professor, Department of Surgery № 1
Krasnodar
O. V. Astafieva
Russian Federation
Olga V. Astafieva, Dr. Sci. (Med.), Professor of the Department of Radiation Diagnostics No. 1
Krasnodar
References
1. Ганичев П. А., Тихомирова А. А., Дохов М.А. (2022). Перспективы использования искусственного интеллекта в радиологии. Краткий обзор // Визуализация в медицине, vol. 4, no. 4, 2022, pp. 7–14.
2. Mello-Thoms, C., & Mello, C. A. B. (2023). Clinical applications of artificial intelligence in radiology. The British journal of radiology, 96(1150), 20221031. https://doi.org/10.1259/bjr.20221031
3. Литвин А.А., Буркин Д.А., Кропинов А.А., and Парамзин Ф.Н. “Радиомика и анализ текстур цифровых изображений в онкологии (обзор)” Современные технологии в медицине, vol. 13, no. 2, 2021, pp. 97–106.
4. Балтер Р.Б., Бикеев Ю.В., Бокерия Е.Л., Дьяченко Ю.Ю., Метелкин П.В., Пекарева Е.О., Передвигина А.В., Поморцев А.В., Пугачева Т.А. Искусственный интеллект в ультразвуковой диагностике. Версия 1.0 : учебное пособие. – М.: МЕДпресс-информ, 2025. – 147 с. – ISBN 978-5-907849-05-1. https://doi.org/10.24421/MP.2024.71.75.001
5. Поморцев А. В., Редько А. Н., Барсукова Е. А., Матосян М. А., Дьяченко Ю. Ю., Дьяченко Р. А., Белоглядова И. А., Янаева М. В., Бабаян В. Т. Применение искусственного интеллекта в ультразвуковой диагностике пороков ЦНС плода в сроках гестации с 19 по 22 неделю беременности // Инновационная медицина Кубани. 2024. № 2. С. 42–47. https://doi.org/10.35401/2541-9897-2024-9-2-42-47
6. Поморцев А. В., Карахалис М. Н., Матулевич С. А., Дащян Г. А., Халафян А. А., Сенча А. Н. Пороки развития сердца плода: факторы риска и возможности ультразвукового метода при первом скрининге // Инновационная медицина Кубани. 2023. № 4. С. 51–59. https://doi.org/10.35401/2541-9897-2023-8-4-51-59 Shen, Y. T., Chen, L., Yue, W. W., & Xu, H. X. (2021). Artificial intelligence in ultrasound. European journal of radiology, 139, 109717. https://doi.org/10.1016/j.ejrad.2021.109717
7. Komatsu, M., Teraya, N., Natsume, T., Harada, N., Takeda, K., & Hamamoto, R. (2025). Clinical Application of Artificial Intelligence in Ultrasound Imaging for Oncology. JMA journal, 8(1), 18–25. https://doi.org/10.31662/jmaj.2024-0203
8. Moro, F., Ciancia, M., Zace, D., Vagni, M., Tran, H. E., Giudice, M. T., Zoccoli, S. G., Mascilini, F., Ciccarone, F., Boldrini, L., D’Antonio, F., Scambia, G., & Testa, A. C. (2024). Role of artificial intelligence applied to ultrasound in gynecology oncology: A systematic review. International journal of cancer, 155(10), 1832–1845. https://doi.org/10.1002/ijc.35092
9. Teuwen, J., Gouw, Z. A. R., & Sonke, J. J. (2022). Artificial Intelligence for Image Registration in Radiation Oncology. Seminars in radiation oncology, 32(4), 330–342. https://doi.org/10.1016/j.semradonc.2022.06.003
10. Thwaites, D., Moses, D., Haworth, A., Barton, M., & Holloway, L. (2021). Artificial intelligence in medical imaging and radiation oncology: Opportunities and challenges. Journal of medical imaging and radiation oncology, 65(5), 481–485. https://doi.org/10.1111/1754-9485.13275
11. Parkinson, C., Matthams, C., Foley, K., & Spezi, E. (2021). Artificial intelligence in radiation oncology: A review of its current status and potential application for the radiotherapy workforce. Radiography (London, England: 1995), 27 Suppl 1, S63–S68. https://doi.org/10.1016/j.radi.2021.07.012
12. Zhu, S., Ma, S. J., Farag, A., Huerta, T., Gamez, M. E., & Blakaj, D. M. (2025). Artificial Intelligence, Machine Learning and Big Data in Radiation Oncology. Hematology/oncology clinics of North America, 39(2), 453–469. https://doi.org/10.1016/j.hoc.2024.12.002
13. Moore, N. S., McWilliam, A., & Aneja, S. (2023). Bladder Cancer Radiation Oncology of the Future: Prognostic Modelling, Radiomics, and Treatment Planning With Artificial Intelligence. Seminars in radiation oncology, 33(1), 70–75. https://doi.org/10.1016/j.semradonc.2022.10.009
14. Kelly, B. S., Judge, C., Bollard, S. M., Clifford, S. M., Healy, G. M., Aziz, A., Mathur, P., Islam, S., Yeom, K. W., Lawlor, A., & Killeen, R. P. (2022). Radiology artificial intelligence: a systematic review and evaluation of methods (RAISE). European radiology, 32(11), 7998–8007. https://doi.org/10.1007/s00330-022-08784-6
15. Podină, N., Gheorghe, E. C., Constantin, A., Cazacu, I., Croitoru, V., Gheorghe, C., Balaban, D. V., Jinga, M., Țieranu,C. G., & Săftoiu, A. (2025). Artificial Intelligence in Pancreatic Imaging: A Systematic Review. United European gastroenterology journal, 13(1), 55–77. https://doi.org/10.1002/ueg2.12723
16. Abel, L., Wasserthal, J., Weikert, T., Sauter, A. W., Nesic, I., Obradovic, M., Yang, S., Manneck, S., Glessgen, C., Ospel, J. M., Stieltjes, B., Boll, D. T., & Friebe, B. (2021). Automated Detection of Pancreatic Cystic Lesions on CT Using Deep Learning. Diagnostics (Basel, Switzerland), 11(5), 901. https://doi.org/10.3390/diagnostics11050901
17. Aggarwal, R., Sounderajah, V., Martin, G., Ting, D. S. W., Karthikesalingam, A., King, D., Ashrafian, H., & Darzi, A. (2021). Diagnostic accuracy of deep learning in medical imaging: a systematic review and meta-analysis. NPJ digital medicine, 4(1), 65. https://doi.org/10.1038/s41746-021-00438-z
18. Bhinder, B., Gilvary, C., Madhukar, N. S., & Elemento, O. (2021). Artificial Intelligence in Cancer Research and Precision Medicine. Cancer discovery, 11(4), 900–915. https://doi.org/10.1158/2159-8290.CD-21-0090
19. Jiang, Y., Liang, X., Wang, W., Chen, C., Yuan, Q., Zhang, X., Li, N., Chen, H., Yu, J., Xie, Y., Xu, Y., Zhou, Z., Li, G., & Li, R. (2021). Noninvasive Prediction of Occult Peritoneal Metastasis in Gastric Cancer Using Deep Learning. JAMA network open, 4(1), e2032269. https://doi.org/10.1001/jamanetworkopen.2020.32269
20. Chassagnon, G., De Margerie-Mellon, C., Vakalopoulou, M., Marini, R., Hoang-Thi, T. N., Revel, M. P., & Soyer, P. (2023). Artificial intelligence in lung cancer: current applications and perspectives. Japanese journal of radiology, 41(3), 235–244. https://doi.org/10.1007/s11604-022-01359-x
21. Lo Gullo, R., Marcus, E., Huayanay, J., Eskreis-Winkler, S., Thakur, S., Teuwen, J., & Pinker, K. (2024). Artificial Intelligence-Enhanced Breast MRI: Applications in Breast Cancer Primary Treatment Response Assessment and Prediction. Investigative radiology, 59(3), 230–242. https://doi.org/10.1097/RLI.0000000000001010
22. Liu, J. Q., Ren, J. Y., Xu, X. L., Xiong, L. Y., Peng, Y. X., Pan, X. F., Dietrich, C. F., & Cui, X. W. (2022). Ultrasoundbased artificial intelligence in gastroenterology and hepatology. World journal of gastroenterology, 28(38), 5530–5546. https://doi.org/10.3748/wjg.v28.i38.5530
23. Turkbey, B., & Haider, M. A. (2022). Artificial Intelligence for Automated Cancer Detection on Prostate MRI: Opportunities and Ongoing Challenges, From the AJR Special Series on AI Applications. AJR. American journal of roentgenology, 219(2), 188– 194. https://doi.org/10.2214/AJR.21.26917
24. Kim, Y. H., Kim, G. H., Kim, K. B., Lee, M. W., Lee, B. E., Baek, D. H., Kim, D. H., & Park, J. C. (2020). Application of A Convolutional Neural Network in The Diagnosis of Gastric Mesenchymal Tumors on Endoscopic Ultrasonography Images. Journal of clinical medicine, 9(10), 3162. https://doi.org/10.3390/jcm9103162
25. Salim, M., Liu, Y., Sorkhei, M., Ntoula, D., Foukakis, T., Fredriksson, I., Wang, Y., Eklund, M., Azizpour, H., Smith, K., & Strand, F. (2024). AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial. Nature medicine, 30(9), 2623–2630. https://doi.org/10.1038/s41591-024-03093-5
26. Liu, C. J., Zhang, L., Sun, Y., Geng, L., Wang, R., Shi, K. M., & Wan, J. X. (2023). Application of CT and MRI images based on an artificial intelligence algorithm for predicting lymph node metastasis in breast cancer patients: a meta-analysis. BMC cancer, 23(1), 1134. https://doi.org/10.1186/s12885-023-11638-z
27. Wang, Y. J., Wang, P., Yan, Z., Zhou, Q., Gunturkun, F., Li, P., Hu, Y., Wu, W. E., Zhao, K., Zhang, M., Lv, H., Fu, L., Jin, J., Du, Q., Wang, H., Chen, K., Qu, L., Lin, K., Iv, M., Wang, H., … Gong, J. (2024). Advancing presurgical non-invasive molecular subgroup prediction in medulloblastoma using artificial intelligence and MRI signatures. Cancer cell, 42(7), 1239–1257.e7. https://doi.org/10.1016/j.ccell.2024.06.002
28. Ranjbarzadeh, R., Caputo, A., Tirkolaee, E. B., Jafarzadeh Ghoushchi, S., & Bendechache, M. (2023). Brain tumor segmentation of MRI images: A comprehensive review on the application of artificial intelligence tools. Computers in biology and medicine, 152, 106405. https://doi.org/10.1016/j.compbiomed.2022.106405
29. Deng, F., Xiao, G., Tanzhu, G., Chu, X., Ning, J., Lu, R., Chen, L., Zhang, Z., & Zhou, R. (2025). Predicting Survival Rates in Brain Metastases Patients from Non-Small Cell Lung Cancer Using Radiomic Signatures Associated with Tumor Immune Heterogeneity. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 12(10), e2412590. https://doi.org/10.1002/advs.202412590
30. Kim, H. Y., Cho, S. J., Sunwoo, L., Baik, S. H., Bae, Y. J., Choi, B. S., Jung, C., & Kim, J. H. (2021). Classification of true progression after radiotherapy of brain metastasis on MRI using artificial intelligence: a systematic review and metaanalysis. Neuro-oncology advances, 3(1), vdab080. https://doi.org/10.1093/noajnl/vdab080
31. Tiyarattanachai, T., Apiparakoon, T., Marukatat, S., Sukcharoen, S., Geratikornsupuk, N., Anukulkarnkusol, N., Mekaroonkamol, P., Tanpowpong, N., Sarakul, P., Rerknimitr, R., & Chaiteerakij, R. (2021). Development and validation of artificial intelligence to detect and diagnose liver lesions from ultrasound images. PloS one, 16(6), e0252882. https://doi.org/10.1371/journal.pone.0252882
32. Liu, J. Q., Ren, J. Y., Xu, X. L., Xiong, L. Y., Peng, Y. X., Pan, X. F., Dietrich, C. F., & Cui, X. W. (2022). Ultrasound-based artificial intelligence in gastroenterology and hepatology. World journal of gastroenterology, 28(38), 5530–5546. https://doi.org/10.3748/wjg.v28.i38.5530
33. Kim, Y. H., Kim, G. H., Kim, K. B., Lee, M. W., Lee, B. E., Baek, D. H., Kim, D. H., & Park, J. C. (2020). Application of A Convolutional Neural Network in The Diagnosis of Gastric Mesenchymal Tumors on Endoscopic Ultrasonography Images. Journal of clinical medicine, 9(10), 3162. https://doi.org/10.3390/jcm9103162
34. Shimizu, H., & Nakayama, K. I. (2020). Artificial intelligence in oncology. Cancer science, 111(5), 1452–1460. https://doi.org/10.1111/cas.14377
35. Jiang, Y., Zhang, Z., Yuan, Q., Wang, W., Wang, H., Li, T., Huang, W., Xie, J., Chen, C., Sun, Z., Yu, J., Xu, Y., Poultsides, G. A., Xing, L., Zhou, Z., Li, G., & Li, R. (2022). Predicting peritoneal recurrence and disease-free survival from CT images in gastric cancer with multitask deep learning: a retrospective study. The Lancet. Digital health, 4(5), e340–e350. https://doi.org/10.1016/S2589-7500(22)00040-1
36. Cao, L. L., Peng, M., Xie, X., Chen, G. Q., Huang, S. Y., Wang, J. Y., Jiang, F., Cui, X. W., & Dietrich, C. F. (2022). Artificial intelligence in liver ultrasound. World journal of gastroenterology, 28(27), 3398–3409. https://doi.org/10.3748/wjg.v28.i27.3398
Review
For citations:
Pomortsev A.V., Dyachenko J.Yu., Matosyan M.A., Arutyunyan E.A., Khagurova L.A., Novikova A.S., Nikitina V.R., Katrich A.N., Astafieva O.V. A Systematic Literature Review on the Use of Artificial Intelligence in Medical Imaging in the Diagnosis of Oncologic Pathology. Innovative Medicine of Kuban. 2026;11(1-1):55-61. (In Russ.)
JATS XML




























