SURGERY FOR LATE RADIATION NECROSIS FOCI IN THE FUNCTIONALLY IMPORTANT CEREBRAL AREAS
Abstract
Background. Appearance and development of new radiotherapy methods for primary and secondary cerebral tumors resulted in more frequent diagnosis of post radiosurgical complications. A common sequel of treatment with linear accelerators is radiolesions of brain tissue.
Objective. Study outcomes of surgical treatment for cerebral radiation necrosis foci.
Materials and Methods. We included 3 patients with late radiolesion foci of brain tissue with progredient course, operated on in Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, for the period since January 1, 2015 to April 30, 2017. Age rate was 61–65 years and mean age was 63 years. Below we present a clinical case of surgical treatment for post radiation surgery necrosis.
Results and discussion. Increased focal volume in the late radiotherapy period with simultaneously expressed rise of local hypostasis in brain tissue could indicate development of a late post-radiation perifocal necrosis.
Conclusion. Our observations showed surgical efficiency for post-radiosurgery complications treatment.
About the Authors
G. I. Kovalev
Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, The Krasnodar Krai Ministry of Health
Russian Federation
Russian Federation
I. S. Blumenau
Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, The Krasnodar Krai Ministry of Health
Russian Federation
Russian Federation
G. G. Muzlaev
Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1, The Krasnodar Krai Ministry of Health; Kuban State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
References
1. Barajas RF, Chang JS, Sneed PK, Segal MR, McDermott MW, Cha S. Distinguishing recurrent intraaxial metastatic tumor from radiation necrosis following gamma knife radiosurgery using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Am J Neuroradiol. 2009;30:367–72. PMID: 19022867. PMCID: PMC7051401. doi:10.3174/ajnr.A1362
2. Flickinger JC, Kondziolka D, Lunsford LD, et al. A multiinstitutional experience with stereotactic radiosurgery for solitary brain metastasis. Int J Radiat Oncol Biol Phys. 1994;28:797–802. PMID: 8138431. doi:10.1016/0360-3016(94)90098-1
3. Fujii T, Misumi S, Shibasaki T, et al. Treatment of delayed brain injury after pituitary irradiation. No Shinkei Geka. 1988;16:241–7. (In Japanese). PMID: 2453809.
4. Gonzalez J, Kumar AJ, Conrad ChA, Levin VA. Effect of bevacizumab on radiation necrosis of the brain. Int J Radiat Oncol Biol Phys. 2007;67:323–6. PMID: 17236958. doi:10.1016/j.ijrobp.2006.10.010
5. Kumar AJ, Leeds NE, Fuller GN, et al. Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatment. Radiology. 2000;217:377–84. PMID: 11058631. doi:10.1148/radiology.217.2.r00nv36377
6. Patchell RA. The management of brain metastases. Cancer Treat Rev. 2003;29:533–40. PMID: 14585263. doi:10.1016/s0305-7372(03)00105-1
7. Ruben JD, Dally M, Bailey M, Smith R, McLean CA, Fedele P. Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy. Int J Radiat Oncol Biol Phys. 2006;65:499–508. PMID: 16517093. doi:10.1016/j.ijrobp.2005.12.002
Review
For citations:
Kovalev G.I., Blumenau I.S., Muzlaev G.G. SURGERY FOR LATE RADIATION NECROSIS FOCI IN THE FUNCTIONALLY IMPORTANT CEREBRAL AREAS. Innovative Medicine of Kuban. 2017;6(2):38-41. (In Russ.)
Views:
636
Email this article 
