Циркадные ритмы печени и их половой диморфизм: современное состояние проблемы
https://doi.org/10.35401/2541-9897-2024-9-2-108-114
Аннотация
Ритмичность процессов функционирования жизнедеятельности на клеточном, органном и системном уровнях является одним из фундаментальных свойств живого. Среди широкого спектра биоритмов наиболее важными для млекопитающих являются циркадианные (циркадные) ритмы. У млекопитающих циркадные ритмы согласовывают протекание широкого спектра физиологических процессов c постоянно меняющимися условиями окружающей среды, в первую очередь, со световым режимом. Данные об особенностях циркадных ритмов печени – важнейшего органа поддержания гомеостаза – ограничены, а иногда и вовсе противоречивы. Целью настоящей статьи является анализ современных научных работ, посвященных вопросам организации суточных ритмов на генном, клеточном и органном уровнях. Актуальность данного обзора обусловлена тем, что за последние десятилетия накоплен значительный объем знаний о том, что нарушение нормальной циркадной ритмичности печени лежит в основе развития ряда тяжелых патологий. В статье освещены некоторые аспекты нормальной циркадной ритмичности функционирования печени и роли нарушения циркадных ритмов в возникновении некоторых патологий. Особое внимание уделено малоизученному вопросу половых различий в суточной ритмичности функционирования печени млекопитающих.
Об авторах
Д. А. Арешидзе
Научно-исследовательский институт морфологии человека им. акад. А.П. Авцына Российского научного центра хирургии им. акад. Б.В. Петровского
Россия
Россия
Арешидзе Давид Александрович, к. б. н., заведующий лаборатории патологии клетки
117418, Москва, ул. Цюрупы, д. 3
Л. В. Кактурский
Научно-исследовательский институт морфологии человека им. акад. А.П. Авцына Российского научного центра хирургии им. акад. Б.В. Петровского
Россия
Россия
Кактурский Лев Владимирович, д. м. н., профессор, член-корреспондент РАН, научный руководитель
Москва
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Рецензия
Для цитирования:
Арешидзе Д.А., Кактурский Л.В. Циркадные ритмы печени и их половой диморфизм: современное состояние проблемы. Инновационная медицина Кубани. 2024;(2):108-114. https://doi.org/10.35401/2541-9897-2024-9-2-108-114
For citation:
Areshidze D.A., Kakturskiy L.V. Circadian Rhythms of the Liver and Their Sexual Dimorphism: Current State of the Problem. Innovative Medicine of Kuban. 2024;(2):108-114. https://doi.org/10.35401/2541-9897-2024-9-2-108-114
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