Gastric cancer is one the most serious oncological pathologies and it occupies the third position in the structure of oncological mortality. Latest achievements in surgery for gastric cancer are linked to extended lymph node dissection (D2), still, long-term results depend on carcinoma extension, regional lymph node involvement, tumor invasion depth and differentiation. Background: study survival in the patients treated for locally advanced gastric cancer regarding lymph node dissection volume and specific tumor characteristics. Materials and methods: applying Kaplan-Meier method and variance analysis we studied long-term results of 662 patients with gastric cancer with minimal lymph node dissection (D1) in the control group and extended lymph node dissection (D2) in the main group depending on 10 different features of tumor stage. Results: while analyzing long-term results of treatment we defined authentic advantage in patients in the main group according to their total and non-recurrent 5-year survival rates, and the median in the control group was 32,0 months, and in the main group it was 46,0 months. Inherent effect of extended lymph node dissection (D2) was defined at the level of any tumor characteristics, meanwhile their impacts including stage, metastatic spread and regional lymph node invasion and low tumor differentiation had more massive influence on patient survival rate than extended lymph node dissection. Conclusions: surgery for gastric cancer should be accompanied by extended lymph node dissection (D2), and its impact is seen at any tumor clinic stage. The best observed treatment effect in patients with gastric cancer could be achieved while following therapy standards and diagnosing tumors at early stages.

Background: We analyzed results in cases with surface defects covered with non-free vascularized gastrocnemius muscle flaps. We observed patients with various traumatological and orthopedic pathologies. Materials and Methods: in the present article we analyzed treatment results of 8 patients with soft tissue defects in the area of knee joints and upper third of shin. In all these cases we applied non-free vascularized muscle flaps taken from gastrocnemius muscle and simultaneous autodermoplasty. We described various techniques performed in patients with combined traumas. Conclusions: Transposition of non- free vascularized flaps from gastrocnemius muscle in patients with traumatological and orthopedic pathologies allows to achieve restoration of surface tissues in the area of knee joints and shin when defects occur after traumas and postoperative purulent complications.

Standard surgical treatment for rectal cancer is a total mesorectumectomy (TME) and it demands performing proper pathohistological examination of the removed specimen to select patients with high risk of local recurrence development and those indicated for adjuvant therapy. Pathologists should value quality of surgical intervention, examine both distal and circular resection margins (surgically mobilized mesorectal surface), define surgical clearance (distance from the circular resection margine to the tumor itself), perform pathological staging ((у)pTpN), determine histological type and stage of tumor differentiation. In this paper we describe a route of the specimen removed after the surgery for rectal cancer and its pathohistological examination technique which is based on the guidances of the British Royal Society of Pathologists specialized to the Regional Clinic Hospital requirements.

We have examined 250 patients (456 eyes) with non- stabilized open-angle glaucoma and normalized intraocular pressure. In 242 (96,9%) cervical osteochondrosis was revealed. Patients were divided into two equal groups. The control group received traditional conservative therapy. Patients in the main group were administered treatment of cervical osteochondrosis. In the main group the positive effect was observed in 208 eyes (91,6%), and in the control group - in 125 eyes (55%).

Lymphomas are a heterogeneous group of diseases with various histological signs which are different in clinical course and prognosis. They all are divided into main groups: B-cell lymphoproliferative diseases, Т-cell lymphoproliferative diseases, Hodgkin disease. The first two groups (excluding leukoses) are defined as "non-Hodgkin lymphomas” (NHL). They are about 5–6% of all malignant neoplasms and in their structure they occupy the fifth position in overseas countries. In the present article we present a clinical case with diffuse B-cell large cell lymphoma of the small pelvis with retroperitoneal space infiltration, root of mesentery, small pelvis fat tissue.

In the present study we demonstrated two clinical cases with patients treated for colorectal polyposis. Patients were treated out-patiently in the diagnostic center. Performed diagnostic and treatment methods encouraged full recovery in short terms without patient hospitalization and could be recommended for wide introduction in the clinic.

For the last several years while treating acute ischemic strokes methods of endovascular interventions are favorably applied. Similar treatment methods are characterized by large therapeutic window, high efficiency and effect persistence comparing to systemic thrombolytic therapy. In the present article we present clinic observance for endovascular mechanical thromboembolectomy with stent-retriever and further balloon angioplasty in a patient with acute ischemic stroke in the area of stenotic lesion of internal carotid artery wedge-shaped aspect.

We performed retrospective analysis for incidence and mortality rates in patients with skin melanoma in Krasnodar region for a 5-year period (2011–2015) and compared it to average Russian rates. All results of non-randomized and randomized series which demonstrated comparative effectiveness for various treatment agents were analyzed. We discussed significance of several agents indicated for patients in mono- and combined regimens.

In donor organ recipients we observe sufficiently high risk of invasive mycotic infection development and most of them are caused by Candida spp and Aspergillus spp. Clinical evidence of invasive candidiasis are diverse and this fact makes early diagnosis complicated. At the same time, despite relative frequency of invasive mycoses at transplantation, there are no definite recommendations for diagnosis, treatment and prevention of mycotic infections. In most cases physicians should rely on their own clinical experience. In the present study we demonstrated modern approaches to diagnosis and treatment for invasive candidiasis in donor organ recipients.

The article presents the basic provisions of the selection of patients for transplantation of the heart, and the volume of the order of examination of potential recipients, the organization of the selection and monitoring of recipients in our center. Also analyzed the experience of the disease and outcomes of patients at the waiting list for a heart transplant for the 6 years of follow up in our center.